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Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer

  • Authors:
    • Shuliang Liu
    • Hongji Yang
    • Xingping Ge
    • Lingfei Su
    • Aifeng Zhang
    • Liang Liang
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China, Department of Respiratory Medicine, Affiliated Hospital of Taishan Medical University, Tai'an, Shandong 271000, P.R. China, Department of Radiotherapy, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China, Oncology Center, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3941-3943
    |
    Published online on: September 22, 2016
       https://doi.org/10.3892/ol.2016.5171
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Abstract

The aim of the study was to examine the drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer (NSCLC). In total, 156 NSCLC patients without surgical treatment were selected, including 117 cases of adenocarcinoma (75%), to receive single gefitinib 0.25 g/day or combined with platinum chemotherapy. Computed tomo­graphy was used to evaluate tumor growth for the response and non-response groups. The chemotherapy regimen was changed or combined with radiotherapy in the non-response group. Tumor progression or metastasis in the response group was considered as the generation of drug resistance. The chemotherapy regimen was altered in the response group. Eleven cases had tumor response in the non-response group after the chemotherapy regimen was adjusted (20%), 33 cases had complete response (CR) (32.7%), 44 cases had partial response (PR) (43.6%), and 24 cases had stable disease (SD) (23.8%) in the response group. The drug resistance rates of CR, PR, and SD showed no significant difference (P>0.05). However, the drug-resistant time of CR was significantly delayed and the difference was statistically significant (P<0.05). The response rates of CR, PR, and SD patients regaining the response rate showed no statistical significance after the chemotherapy regimen was adjusted, and the difference was not statistically significant (P>0.05). In conclusion, gefitinib-targeted therapy in NSCLC showed certain drug resistance, which may not be related to the response.
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Copy and paste a formatted citation
Spandidos Publications style
Liu S, Yang H, Ge X, Su L, Zhang A and Liang L: Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer. Oncol Lett 12: 3941-3943, 2016.
APA
Liu, S., Yang, H., Ge, X., Su, L., Zhang, A., & Liang, L. (2016). Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer. Oncology Letters, 12, 3941-3943. https://doi.org/10.3892/ol.2016.5171
MLA
Liu, S., Yang, H., Ge, X., Su, L., Zhang, A., Liang, L."Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer". Oncology Letters 12.5 (2016): 3941-3943.
Chicago
Liu, S., Yang, H., Ge, X., Su, L., Zhang, A., Liang, L."Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer". Oncology Letters 12, no. 5 (2016): 3941-3943. https://doi.org/10.3892/ol.2016.5171
Copy and paste a formatted citation
x
Spandidos Publications style
Liu S, Yang H, Ge X, Su L, Zhang A and Liang L: Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer. Oncol Lett 12: 3941-3943, 2016.
APA
Liu, S., Yang, H., Ge, X., Su, L., Zhang, A., & Liang, L. (2016). Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer. Oncology Letters, 12, 3941-3943. https://doi.org/10.3892/ol.2016.5171
MLA
Liu, S., Yang, H., Ge, X., Su, L., Zhang, A., Liang, L."Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer". Oncology Letters 12.5 (2016): 3941-3943.
Chicago
Liu, S., Yang, H., Ge, X., Su, L., Zhang, A., Liang, L."Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer". Oncology Letters 12, no. 5 (2016): 3941-3943. https://doi.org/10.3892/ol.2016.5171
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