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Article

Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis

  • Authors:
    • Yong Jia
    • Hua Yuan
    • Shouqin Shan
    • Gang Xu
    • Jie Yu
    • Chenguang Zhao
    • Xiang Mou
  • View Affiliations / Copyright

    Affiliations: Orthopedic Center of Chinese PLA, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang 830000, P.R. China, Department of Rehabilitation, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Rehabilitation, Qingdao First Sanatorium of Jinan Military Region, Qingdao, Shandong 266071, P.R. China, Department of Information, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang 830000, P.R. China
  • Pages: 4187-4194
    |
    Published online on: September 26, 2016
       https://doi.org/10.3892/ol.2016.5185
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Abstract

Corosolic acid (CRA), a pentacyclic triterpene isolated from medicinal herbs, has been reported to exhibit anticancer properties in several cancers. However, the anticancer activity of CRA in osteosarcoma cells is still unclear. In the present study, the inhibitory effect of CRA in osteosarcoma MG‑63 cells was investigated, and the results revealed that CRA significantly inhibited the viability of MG‑63 cells in a dose‑ and time‑dependent manner. A typical apoptotic hallmark such as DNA ladder was detected by agarose gel electrophoresis following treatment with CRA. Further experiments demonstrated that CRA induced apoptosis of MG‑63 cells by flow cytometry using propidium iodide and annexin V staining. In addition, it was observed that the apoptosis of MG‑63 cells induced by CRA was closely associated with activation of caspase‑3 and caspase‑9, loss of mitochondrial membrane potential, and release of cytochrome c from mitochondria, suggesting that CRA may trigger the activation of the mitochondria‑mediated apoptosis pathway. In addition, the inhibition of caspase activity attenuated the CRA‑induced apoptosis of MG‑63 cells, which further confirmed the role of the mitochondrial pathway in CRA‑induced apoptosis. These results indicated that CRA could induce the apoptosis of osteosarcoma cells through activating the mitochondrial pathway, which provides an evidence that CRA may be a useful chemotherapeutic agent for osteosarcoma.
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View References

1 

Nho KJ, Chun JM and Kim HK: Corosolic acid induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro. Food Chem Toxicol. 56:8–17. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Li B, Meng X, Zhu L, Jiao X and Zhang J: Application of high-speed counter-current chromatography for isolation of triterpenes from Schisandra Chinensis (Turcz.) Baill and induction apoptosis mechanism of HSC-T6. Biomed Mater Eng. 24:969–977. 2014.PubMed/NCBI

3 

Miura T, Takagi S and Ishida T: Management of diabetes and its complications with Banaba (Lagerstroemia speciosa L.) and corosolic acid. Evid Based Complement Alternat Med. 2012:8714952012. View Article : Google Scholar : PubMed/NCBI

4 

Caligiani A, Malavasi G, Palla G, Marseglia A, Tognolini M and Bruni R: A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. Food Chem. 136:735–741. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Zong W and Zhao G: Corosolic acid isolation from the leaves of Eriobotrta japonica showing the effects on carbohydrate metabolism and differentiation of 3T3-L1 adipocytes. Asia Pac J Clin Nutr. 16(Suppl 1): 346–352. 2007.PubMed/NCBI

6 

Yin MC, Lin MC, Mong MC and Lin CY: Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice. J Agric Food Chem. 60:7697–7701. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Chen H, Yang J, Zhang Q, Chen LH and Wang Q: Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by regulating the nuclear factor-kB signaling pathway and inhibiting monocyte chemoattractant protein-1 expression. Circ J. 76:995–1003. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Takagi S, Miura T, Ishihara E, Ishida T and Chinzei Y: Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice. Biomed Res. 31:213–218. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Klein G, Kim J, Himmeldirk K, Cao Y and Chen X: Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa. Evid Based Complement Alternat Med. 4:401–407. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Fujiwara Y, Komohara Y, Ikeda T and Takeya M: Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. Cancer Sci. 102:206–211. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Ahn KS, Hahm MS, Park EJ, Lee HK and Kim IH: Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 64:468–470. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Lee MS, Cha EY, Thuong PT, Kim JY, Ahn MS and Sul JY: Down-regulation of human epidermal growth factor receptor 2/neu oncogene by corosolic acid induces cell cycle arrest and apoptosis in NCI-N87 human gastric cancer cells. Biol Pharm Bull. 33:931–937. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Gatta G, Capocaccia R, Stiller C, Kaatsch P, Berrino F and Terenziani M: EUROCARE Working Group: Childhood cancer survival trends in Europe: A EUROCARE Working Group study. J Clin Oncol. 23:3742–3751. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Sulzbacher I, Birner P, Trieb K, Pichlbauer E and Lang S: The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter. J Clin Pathol. 55:381–385. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Federman N, Bernthal N, Eilber FC and Tap WD: The multidisciplinary management of osteosarcoma. Curr Treat Options Oncol. 10:82–93. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Lewis IJ, Nooij MA, Whelan J, Sydes MR, Grimer R, Hogendoorn PC, Memon MA, Weeden S, Uscinska BM, van Glabbeke M, et al: Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: A randomized phase III trial of the European Osteosarcoma Intergroup. J Natl Cancer Inst. 99:112–128. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Buddingh EP, Anninga JK, Versteegh MI, Taminiau AH, Egeler RM, van Rijswijk CS, Hogendoorn PC, Lankester AC and Gelderblom H: Prognostic factors in pulmonary metastasized high-grade osteosarcoma. Pediatr Blood Cancer. 54:216–221. 2010.PubMed/NCBI

18 

Fischer U and Schulze-Osthoff K: New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev. 57:187–215. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Cotter TG: Apoptosis and cancer: The genesis of a research field. Nat Rev Cancer. 9:501–507. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Cohen Z, Maimon Y, Yoeli-Lerner M, Yang P, Samuels N and Berger R: Selective anticancer effects and protection from chemotherapy by the botanical compound LCS101: Implications for cancer treatment. Int J Oncol. 46:308–316. 2015.PubMed/NCBI

21 

Lowe SW and Lin AW: Apoptosis in cancer. Carcinogenesis. 21:485–495. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Roy AM, Baliga MS and Katiyar SK: Epigallocatechin-3-gallate induces apoptosis in estrogen receptor-negative human breast carcinoma cells via modulation in protein expression of p53 and Bax and caspase-3 activation. Mol Cancer Ther. 4:81–90. 2005.PubMed/NCBI

23 

Ariffin SH, Yeen WW, Abidin IZ, Wahab RM Abdul, Ariffin ZZ and Senafi S: Cytotoxicity effect of degraded and undegraded kappa and iota carrageenan in human intestine and liver cell lines. BMC Complement Altern Med. 14:5082014. View Article : Google Scholar : PubMed/NCBI

24 

Mantena SK, Sharma SD and Katiyar SK: Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis. 27:2018–2027. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Singh T, Sharma SD and Katiyar SK: Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo. PLoS One. 6:e274442011. View Article : Google Scholar : PubMed/NCBI

26 

Wang F, Franco R, Skotak M, Hu G and Chandra N: Mechanical stretch exacerbates the cell death in SH-SY5Y cells exposed to paraquat: Mitochondrial dysfunction and oxidative stress. Neurotoxicology. 41:54–63. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Zhang Y, Li B, Ji ZZ and Zheng PS: Notch1 regulates the growth of human colon cancers. Cancer. 116:5207–5218. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Song TH, Yang JY, Jeong IK, Park JS, Jee YK, Kim YS and Lee KY: Paraquat-induced apoptotic cell death in lung epithelial cells. Tuberc Respir Dis. 61:366–373. 2006. View Article : Google Scholar

29 

Zhou J, Li P, Xue X, He S, Kuang Y, Zhao H, Chen S, Zhi Q and Guo X: Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. Toxicol Lett. 222:139–145. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Philchenkov A: Caspases: Potential targets for regulating cell death. J Cell Mol Med. 8:432–444. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Reed JC: Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol. 7:541–546. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Xiao X, Chen L, Ouyang Y, Zhu W, Qiu P, Su X, Dou Y, Tang L, Yan M, Zhang H, et al: Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways. Oncol Lett. 8:645–650. 2014.PubMed/NCBI

33 

Chen Q, Liu XF and Zheng PS: Grape seed proanthocyanidins (GSPs) inhibit the growth of cervical cancer by inducing apoptosis mediated by the mitochondrial pathway. PLoS One. 9:e1070452014. View Article : Google Scholar : PubMed/NCBI

34 

Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y and Ling C: Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells. Cancer Lett. 284:229–237. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Shi Z, Huang X, Liu B, Tao H, Cai Y and Tang R: Biological response of osteosarcoma cells to size-controlled nanostructured hydroxyapatite. J Biomater Appl. 25:19–37. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Kuijjer ML, Namløs HM, Hauben EI, Machado I, Kresse SH, Serra M, Llombart-Bosch A, Hogendoorn PC, Meza-Zepeda LA, Myklebost O and Cleton-Jansen AM: mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts. BMC Med Genomics. 4:662011. View Article : Google Scholar : PubMed/NCBI

37 

Biao LU: Correlation between ErbB2 expression and survival rates of osteosarcoma patients. Medical Journal of Wuhan University. 2:273–276. 2014.

38 

Sung B, Kang YJ, Kim DH, Hwang SY, Lee Y, Kim M, Yoon JH, Kim CM, Chung HY and Kim ND: Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway. Int J Mol Med. 33:943–949. 2014.PubMed/NCBI

39 

Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M and Komohara Y: Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. Oncol Lett. 6:1619–1623. 2013.PubMed/NCBI

40 

Thompson CB: Apoptosis in the pathogenesis and treatment of disease. Science. 267:1456–1462. 1995. View Article : Google Scholar : PubMed/NCBI

41 

Correa P and Miller MJ: Carcinogenesis, apoptosis and cell proliferation. Br Med Bull. 54:151–162. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Ambrosini G, Adida C and Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 3:917–921. 1997. View Article : Google Scholar : PubMed/NCBI

43 

Zou WW, Xiao HP, Gu MN, Liu KX and Liu ZQ: Propofol induces rat embryonic neural stem cell apoptosis by activating both extrinsic and intrinsic pathways. Mol Med Rep. 7:1123–1128. 2013.PubMed/NCBI

44 

Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, Schuler M and Green DR: Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science. 303:1010–1014. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Tan J, Zhuang L, Leong HS, Iyer NG, Liu ET and Yu Q: Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells. Cancer Res. 65:9012–9020. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD: The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science. 275:1132–1136. 1997. View Article : Google Scholar : PubMed/NCBI

47 

Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH and Peter ME: Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14:5579–5588. 1995.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jia Y, Yuan H, Shan S, Xu G, Yu J, Zhao C and Mou X: Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis. Oncol Lett 12: 4187-4194, 2016.
APA
Jia, Y., Yuan, H., Shan, S., Xu, G., Yu, J., Zhao, C., & Mou, X. (2016). Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis. Oncology Letters, 12, 4187-4194. https://doi.org/10.3892/ol.2016.5185
MLA
Jia, Y., Yuan, H., Shan, S., Xu, G., Yu, J., Zhao, C., Mou, X."Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis". Oncology Letters 12.5 (2016): 4187-4194.
Chicago
Jia, Y., Yuan, H., Shan, S., Xu, G., Yu, J., Zhao, C., Mou, X."Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis". Oncology Letters 12, no. 5 (2016): 4187-4194. https://doi.org/10.3892/ol.2016.5185
Copy and paste a formatted citation
x
Spandidos Publications style
Jia Y, Yuan H, Shan S, Xu G, Yu J, Zhao C and Mou X: Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis. Oncol Lett 12: 4187-4194, 2016.
APA
Jia, Y., Yuan, H., Shan, S., Xu, G., Yu, J., Zhao, C., & Mou, X. (2016). Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis. Oncology Letters, 12, 4187-4194. https://doi.org/10.3892/ol.2016.5185
MLA
Jia, Y., Yuan, H., Shan, S., Xu, G., Yu, J., Zhao, C., Mou, X."Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis". Oncology Letters 12.5 (2016): 4187-4194.
Chicago
Jia, Y., Yuan, H., Shan, S., Xu, G., Yu, J., Zhao, C., Mou, X."Corosolic acid inhibits the proliferation of osteosarcoma cells by inducing apoptosis". Oncology Letters 12, no. 5 (2016): 4187-4194. https://doi.org/10.3892/ol.2016.5185
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