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Article

18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor

  • Authors:
    • Sied Kebir
    • Okka Kimmich
    • Pitt Niehusmann
    • Florian C. Gaertner
    • Markus Essler
    • Jennifer Landsberg
    • Thomas Klockgether
    • Matthias Simon
    • Ulrich Herrlinger
    • Martin Glas
  • View Affiliations / Copyright

    Affiliations: Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, 53127 Bonn, Germany, Department of Neurology, University of Bonn Medical Center, 53127 Bonn, Germany, Department of Neuropathology, University of Bonn Medical Center, 53127 Bonn, Germany, Department of Nuclear Medicine, University of Bonn Medical Center, 53127 Bonn, Germany, Laboratory of Experimental Dermatology, Department of Dermatology and Allergy, University of Bonn Medical Center, 53127 Bonn, Germany, Department of Neurosurgery, University of Bonn Medical Center, 53127 Bonn, Germany
  • Pages: 4705-4707
    |
    Published online on: October 10, 2016
       https://doi.org/10.3892/ol.2016.5234
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Abstract

Diagnosis in patients with a suspected malignant intramedullary lesion that requires biopsy for definitive diagnosis may be challenging, as spinal cord surgery carries the risk of irreversible neurological deficits. The current study presents the first case of 18F-fluoroethyl-L-tyrosine (18F-FET) positron emission tomography (PET) imaging in a patient with a spinal cord tumor. The patient was unsuitable for magnetic resonance imaging due to his implanted cardiac defibrillator. 18F‑FET PET indicated a high‑grade malignancy of the spinal cord, justifying tumor biopsy. Histological analysis was compatible with a malignant melanoma. This is also the first report demonstrating the FET‑PET appearance/metabolic phenotype of a malignant melanoma of the spinal cord.
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Copy and paste a formatted citation
Spandidos Publications style
Kebir S, Kimmich O, Niehusmann P, Gaertner FC, Essler M, Landsberg J, Klockgether T, Simon M, Herrlinger U, Glas M, Glas M, et al: 18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor. Oncol Lett 12: 4705-4707, 2016.
APA
Kebir, S., Kimmich, O., Niehusmann, P., Gaertner, F.C., Essler, M., Landsberg, J. ... Glas, M. (2016). 18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor. Oncology Letters, 12, 4705-4707. https://doi.org/10.3892/ol.2016.5234
MLA
Kebir, S., Kimmich, O., Niehusmann, P., Gaertner, F. C., Essler, M., Landsberg, J., Klockgether, T., Simon, M., Herrlinger, U., Glas, M."18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor". Oncology Letters 12.6 (2016): 4705-4707.
Chicago
Kebir, S., Kimmich, O., Niehusmann, P., Gaertner, F. C., Essler, M., Landsberg, J., Klockgether, T., Simon, M., Herrlinger, U., Glas, M."18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor". Oncology Letters 12, no. 6 (2016): 4705-4707. https://doi.org/10.3892/ol.2016.5234
Copy and paste a formatted citation
x
Spandidos Publications style
Kebir S, Kimmich O, Niehusmann P, Gaertner FC, Essler M, Landsberg J, Klockgether T, Simon M, Herrlinger U, Glas M, Glas M, et al: 18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor. Oncol Lett 12: 4705-4707, 2016.
APA
Kebir, S., Kimmich, O., Niehusmann, P., Gaertner, F.C., Essler, M., Landsberg, J. ... Glas, M. (2016). 18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor. Oncology Letters, 12, 4705-4707. https://doi.org/10.3892/ol.2016.5234
MLA
Kebir, S., Kimmich, O., Niehusmann, P., Gaertner, F. C., Essler, M., Landsberg, J., Klockgether, T., Simon, M., Herrlinger, U., Glas, M."18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor". Oncology Letters 12.6 (2016): 4705-4707.
Chicago
Kebir, S., Kimmich, O., Niehusmann, P., Gaertner, F. C., Essler, M., Landsberg, J., Klockgether, T., Simon, M., Herrlinger, U., Glas, M."18F-fluoroethyl-L-tyrosine positron emission tomography-guided diagnosis of a malignant intramedullary spinal cord tumor". Oncology Letters 12, no. 6 (2016): 4705-4707. https://doi.org/10.3892/ol.2016.5234
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