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Review

Familial adenomatous polyposis in China (Review)

  • Authors:
    • Jun Yang
    • Qing Wei Liu
    • Liang Wen Li
    • Qiang Zhi Wang
    • Min Hong
    • Jian Dong
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Internal Medicine‑Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Internal Medicine‑Oncology, Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650106, P.R. China
  • Pages: 4877-4882
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    Published online on: October 31, 2016
       https://doi.org/10.3892/ol.2016.5330
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Abstract

Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a poor prognosis, and has been studied by clinicians and geneticists in China for the past three decades. It is estimated that FAP has an incidence of between 1 in 8,000 and 1 in 10,000 individuals, and accounts for 0.94% of colorectal cancer cases in China. Recent advances in the understanding of FAP suggest that the genotype of the patient may allow for early diagnosis and surveillance, and guide surgical and chemopreventive management. However, the genetic mechanisms of FAP vary between different countries. FAP in China has its own characteristics, and this may be due to ethnic and geographical genetic variation. In the present review the clinical manifestations and genetics of FAP in China are discussed, as well as the surgical strategies, chemotherapeutics and traditional Chinese medicines used in its treatment. Increased insight into the genetic and clinical features of FAP in the Chinese population may aid in the prevention and management of the disorder.
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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Liu QW, Li LW, Wang QZ, Hong M and Dong J: Familial adenomatous polyposis in China (Review). Oncol Lett 12: 4877-4882, 2016.
APA
Yang, J., Liu, Q.W., Li, L.W., Wang, Q.Z., Hong, M., & Dong, J. (2016). Familial adenomatous polyposis in China (Review). Oncology Letters, 12, 4877-4882. https://doi.org/10.3892/ol.2016.5330
MLA
Yang, J., Liu, Q. W., Li, L. W., Wang, Q. Z., Hong, M., Dong, J."Familial adenomatous polyposis in China (Review)". Oncology Letters 12.6 (2016): 4877-4882.
Chicago
Yang, J., Liu, Q. W., Li, L. W., Wang, Q. Z., Hong, M., Dong, J."Familial adenomatous polyposis in China (Review)". Oncology Letters 12, no. 6 (2016): 4877-4882. https://doi.org/10.3892/ol.2016.5330
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Liu QW, Li LW, Wang QZ, Hong M and Dong J: Familial adenomatous polyposis in China (Review). Oncol Lett 12: 4877-4882, 2016.
APA
Yang, J., Liu, Q.W., Li, L.W., Wang, Q.Z., Hong, M., & Dong, J. (2016). Familial adenomatous polyposis in China (Review). Oncology Letters, 12, 4877-4882. https://doi.org/10.3892/ol.2016.5330
MLA
Yang, J., Liu, Q. W., Li, L. W., Wang, Q. Z., Hong, M., Dong, J."Familial adenomatous polyposis in China (Review)". Oncology Letters 12.6 (2016): 4877-4882.
Chicago
Yang, J., Liu, Q. W., Li, L. W., Wang, Q. Z., Hong, M., Dong, J."Familial adenomatous polyposis in China (Review)". Oncology Letters 12, no. 6 (2016): 4877-4882. https://doi.org/10.3892/ol.2016.5330
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