Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy

  • Authors:
    • Shan Li
    • Ting‑Ting Feng
    • Yang Guo
    • Xianjun Yu
    • Qiuyue Huang
    • Liang Zhang
    • Wei Tang
    • Ying Liu
  • View Affiliations

  • Published online on: November 9, 2016     https://doi.org/10.3892/ol.2016.5374
  • Pages: 5370-5376
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Abstract

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized oncoprotein which is involved in the progression of several human malignancies. The present study aimed to investigate its biological function in human triple negative breast cancer (TNBC). The expression of CIP2A in TNBC cells was examined and it was observed that CIP2A was elevated in the TNBC cell line compared with poorly invasive breast cancer cells. CIP2A depletion in TNBC cell lines inhibited proliferation, and induced apoptosis and autophagy. In addition, CIP2A depletion inhibited invasion and migration of TNBC cells. Furthermore, CIP2A depletion downregulated Akt/mTOR/P70S6K phosphorylation. These results validate the role of CIP2A as a invasion‑associated oncoprotein and established CIP2A as a promising therapeutic target of TNBC.
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December-2016
Volume 12 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li S, Feng TT, Guo Y, Yu X, Huang Q, Zhang L, Tang W and Liu Y: Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy. Oncol Lett 12: 5370-5376, 2016
APA
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L. ... Liu, Y. (2016). Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy. Oncology Letters, 12, 5370-5376. https://doi.org/10.3892/ol.2016.5374
MLA
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L., Tang, W., Liu, Y."Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy". Oncology Letters 12.6 (2016): 5370-5376.
Chicago
Li, S., Feng, T., Guo, Y., Yu, X., Huang, Q., Zhang, L., Tang, W., Liu, Y."Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy". Oncology Letters 12, no. 6 (2016): 5370-5376. https://doi.org/10.3892/ol.2016.5374