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Article

Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression

  • Authors:
    • Fanhua Meng
    • Jianhui Wang
    • Fuxiang Ding
    • Yunliang Xie
    • Yingjie Zhang
    • Jie Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Hospital, Jilin University, Changchun, Jilin 130021, P.R. China, Neurology Department 1, The Affiliated Hospital of Beihua University, Jilin 132011, P.R. China, Cardiovascular Department 1, The Affiliated Hospital of Beihua University, Jilin 132011, P.R. China, Neurology Department 2, The Affiliated Hospital of Beihua University, Jilin 132011, P.R. China
  • Pages: 296-300
    |
    Published online on: November 14, 2016
       https://doi.org/10.3892/ol.2016.5383
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Abstract

The incidence rate of Parkinson's disease (PD) is ≤2% in Chinese individuals >65 years old, accounting for 40% of the global total of PD patients. The pathogenesis of PD is not yet clear, and oxidative stress-induced mitochondrial dysfunction is considered to be the main reason for the onset of PD. Studies have shown that matrine exhibits good antioxidant activity. Thus, the present study aimed to observe the protective effect and mechanism of matrine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neuron damage. A total of 25 C57BL male mice were randomly divided into 5 groups, consisting of the control group (group A), the MPTP group (group B) and three matrine (4, 8 and 16 mg/kg) plus MPTP treatment groups (groups C, D and E, respectively). Results from a pole‑climbing test and locomotor activity experiments were recorded. The mice were sacrificed 4 days later and brain dissection was performed. The levels of superoxide dismutase (SOD) and glutathione (GSH) were assessed. The expression level of tyrosine hydroxylase (TH) in the ventral midbrain was studied by immunofluorescence analysis. The expression level of nuclear factor erythroid 2-related factor 2 (Nrf2) in the ventral midbrain was studied by western blot analysis. The experiments were repeated three times. Compared with control mice, the PD mice exhibited the typical behaviors associated with PD; matrine can alleviate this phenomenon, and with increasing matrine concentration, the symptoms were reduced significantly. Compared with the control mice, the PD mice had lower SOD and GSH activity, and matrine partially reversed the change in SOD and GSH activity. Immunofluorescence analysis showed that the level of TH in the ventral midbrain decreased significantly in the PD mice, and that the mice administered matrine showed higher expression of TH and levels of TH‑positive cells. Western blotting results showed that the expression of Nrf2 in the ventral midbrain decreased significantly in the PD mice, and that matrine was able to reverse this phenomenon. In conclusion, by promoting antioxidant-related Nrf2 signaling pathways in the ventral midbrain, matrine can inhibit the oxidative damage of dopamine neurons in PD.
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View References

1 

Barnham KJ, Masters CL and Bush AI: Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov. 3:205–214. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Wood JM and Gupta S: Vitamin D and neurocognitive disorder due to Alzheimer's disease: A review of the literature. Ann Clin Psychiatry. 27:e1–e7. 2015.PubMed/NCBI

3 

Sargolzaei S, Sargolzaei A, Cabrerizo M, Chen G, Goryawala M, Noei S, Zhou Q, Duara R, Barker W and Adjouadi M: A practical guideline for intracranial volume estimation in patients with Alzheimer's disease. BMC Bioinformatics. 16:(Suppl 7). S82015. View Article : Google Scholar

4 

Zhang C, Hu WH, Wu L, Zhang K and Zhang JG: Behavioral effects of deep brain stimulation of the anterior nucleus of thalamus, entorhinal cortex and fornix in a rat model of Alzheimer's disease. Chin Med J (Engl). 128:1190–1195. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Lara H Herman, Alanís-Garza EJ, Puente MF Estrada, Mureyko LL, DA Alarcón Torres and Ixtepan Turrent L: Nutritional approaches to modulate oxidative stress that induce Alzheimer's disease. Nutritional approaches to prevent Alzheimer's disease. Gac Med Mex. 151:245–251. 2015.(In Spanish). PubMed/NCBI

6 

Langston JW and Irwin I: MPTP: Current concepts and controversies. Clin Neuropharmacol. 9:485–507. 1986. View Article : Google Scholar

7 

Alcaraz-Zubeldia M, Rojas P, Boll C and Rios C: Neuroprotective effect of acute and chronic administration of copper (II) sulfate against MPP+ neurotoxicity in mice. Neurochem Res. 26:59–64. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Yacoubian TA and Standaert DG: Targets for neuroprotection in Parkinson's disease. Biochim Biophys Acta. 1792:676–687. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Samii A, Etminan M, Wiens MO and Jafari S: NSAID use and the risk of Parkinson's disease: Systematic review and meta-analysis of observational studies. Drugs Aging. 26:769–779. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Li Y, Wang B, Zhou C and Bi Y: Matrine induces apoptosis in angiotensin II-stimulated hyperplasia of cardiac fibroblasts: Effects on Bcl-2/Bax expression and caspase-3 activation. Basic Clin Pharmacol Toxicol. 101:1–8. 2007. View Article : Google Scholar

11 

Long Y, Lin XT, Zeng KL and Zhang L: Efficacy of intramuscular matrine in the treatment of chronic hepatitis B. Hepatobiliary Pancreat Dis Int. 3:69–72. 2004.PubMed/NCBI

12 

Haiyan W, Yuxiang L, Linglu D, Tingting X, Yinju H, Hongyan L, Lin M, Yuanxu J, Yanrong W and Jianqiang Y: Antinociceptive effects of matrine on neuropathic pain induced by chronic constriction injury. Pharm Biol. 51:844–850. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Li X, Zhou R, Zheng P, Yan L, Wu Y, Xiao X and Dai G: Cardioprotective effect of matrine on isoproterenol-induced cardiotoxicity in rats. J Pharm Pharmacol. 62:514–520. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Li Y, Zhang J, Ma H, Chen X, Liu T, Jiao Z, He W, Wang F, Liu X and Zeng X: Protective role of autophagy in matrine-induced gastric cancer cell death. Int J Oncol. 42:1417–1426. 2013.PubMed/NCBI

15 

Guo L, Xue TY, Xu W and Gao JZ: Effects of matrine on the proliferation and apoptosis of human rhabdomyosarcoma RD cells. Zhongguo Dang Dai Er Ke Za Zhi. 14:780–784. 2012.(In Chinese). PubMed/NCBI

16 

Haga R, Sugimoto K, Nishijima H, Miki Y, Suzuki C, Wakabayashi K, Baba M, Yagihashi S and Tomiyama M: Clinical utility of skin biopsy in differentiating between Parkinson's disease and multiple system atrophy. Parkinsons Dis. 2015:1670382015.PubMed/NCBI

17 

Akbar U, He Y, Dai Y, Hack N, Malaty I, McFarland NR, Hess C, Schmidt P, Wu S and Okun MS: Weight loss and impact on quality of life in Parkinson's disease. PLoS One. 10:e01245412015. View Article : Google Scholar : PubMed/NCBI

18 

Liu HG, Zhang K, Yang AC and Zhang JG: Deep brain stimulation of the subthalamic and pedunculopontine nucleus in a patient with Parkinson's disease. J Korean Neurosurg Soc. 57:303–306. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Sun WH, Liu F, Chen, Y and Zhu YC: Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia/reperfusion. Biochem Biophys Res Commun. 421:164–169. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Bo Young Chung, So Ra Choi, Ik Jun Moon, et al: The glutathione derivative, GSH monoethyl ester, may effectively whiten skin but GSH does not. Int J Mol Sci. 17:E6292016. View Article : Google Scholar : PubMed/NCBI

21 

Zhang HF, Shi LJ, Song GY, Cai ZG, Wang C and An RJ: Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocation. Food Chem Toxicol. 55:70–77. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Abdul-Aziz A, MacEwan DJ, Bowles KM and Rushworth SA: Oxidative stress responses and NRF2 in human leukaemia. Oxid Med Cell Longev. 2015:4546592015.PubMed/NCBI

23 

Fu J, Zheng H, Wang H, Yang B, Zhao R, Lu C, Liu Z, Hou Y, Xu Y, Zhang Q, et al: Protective role of nuclear factor E2-related factor 2 against acute oxidative stress-induced pancreatic β-cell damage. Oxid Med Cell Longev. 2015:6391912015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Meng F, Wang J, Ding F, Xie Y, Zhang Y and Zhu J: Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression. Oncol Lett 13: 296-300, 2017.
APA
Meng, F., Wang, J., Ding, F., Xie, Y., Zhang, Y., & Zhu, J. (2017). Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression. Oncology Letters, 13, 296-300. https://doi.org/10.3892/ol.2016.5383
MLA
Meng, F., Wang, J., Ding, F., Xie, Y., Zhang, Y., Zhu, J."Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression". Oncology Letters 13.1 (2017): 296-300.
Chicago
Meng, F., Wang, J., Ding, F., Xie, Y., Zhang, Y., Zhu, J."Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression". Oncology Letters 13, no. 1 (2017): 296-300. https://doi.org/10.3892/ol.2016.5383
Copy and paste a formatted citation
x
Spandidos Publications style
Meng F, Wang J, Ding F, Xie Y, Zhang Y and Zhu J: Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression. Oncol Lett 13: 296-300, 2017.
APA
Meng, F., Wang, J., Ding, F., Xie, Y., Zhang, Y., & Zhu, J. (2017). Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression. Oncology Letters, 13, 296-300. https://doi.org/10.3892/ol.2016.5383
MLA
Meng, F., Wang, J., Ding, F., Xie, Y., Zhang, Y., Zhu, J."Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression". Oncology Letters 13.1 (2017): 296-300.
Chicago
Meng, F., Wang, J., Ding, F., Xie, Y., Zhang, Y., Zhu, J."Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression". Oncology Letters 13, no. 1 (2017): 296-300. https://doi.org/10.3892/ol.2016.5383
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