H19 promotes endometrial cancer progression by modulating epithelial-mesenchymal transition

  • Authors:
    • Le Zhao
    • Zhen Li
    • Wei Chen
    • Wen Zhai
    • Jingjing Pan
    • Huan Pang
    • Xu Li
  • View Affiliations

  • Published online on: November 16, 2016     https://doi.org/10.3892/ol.2016.5389
  • Pages: 363-369
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Abstract

Endometrial cancer is one of the most common types of gynecological malignancy worldwide. Novel biomarkers and therapeutic targets are imperative for improving patients' survival. Previous studies have suggested the long non‑coding RNA H19 as a potential cancer biomarker. To investigate the role of H19 in endometrial cancer, the present study examined the expression pattern of H19 in endometrial cancer tissues by quantitative polymerase chain reaction, and characterized its function in the endometrial cancer cell line via knocking down its expression with small interfering RNAs. It was found that H19 level was significantly higher in tumor tissues than in paratumoral tissues. Knockdown of H19 did not affect the growth rate of HEC‑1‑B endometrial cancer cells, but significantly suppressed in vitro migration and invasion of HEC‑1‑B cells. Furthermore, H19 downregulation decreased Snail level and increased E‑cadherin expression without affecting vimentin level, indicating partial reversion of epithelial‑mesenchymal transition (EMT). The present findings suggested that H19 contributed to the aggressiveness of endometrial cancer by modulating EMT process.
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January-2017
Volume 13 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhao L, Li Z, Chen W, Zhai W, Pan J, Pang H and Li X: H19 promotes endometrial cancer progression by modulating epithelial-mesenchymal transition. Oncol Lett 13: 363-369, 2017
APA
Zhao, L., Li, Z., Chen, W., Zhai, W., Pan, J., Pang, H., & Li, X. (2017). H19 promotes endometrial cancer progression by modulating epithelial-mesenchymal transition. Oncology Letters, 13, 363-369. https://doi.org/10.3892/ol.2016.5389
MLA
Zhao, L., Li, Z., Chen, W., Zhai, W., Pan, J., Pang, H., Li, X."H19 promotes endometrial cancer progression by modulating epithelial-mesenchymal transition". Oncology Letters 13.1 (2017): 363-369.
Chicago
Zhao, L., Li, Z., Chen, W., Zhai, W., Pan, J., Pang, H., Li, X."H19 promotes endometrial cancer progression by modulating epithelial-mesenchymal transition". Oncology Letters 13, no. 1 (2017): 363-369. https://doi.org/10.3892/ol.2016.5389