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Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis

  • Authors:
    • Guglielmo Salvatori
    • Silvia Foligno
    • Pietro Sirleto
    • Silvia Genovese
    • Serena Russo
    • Valentina Coletti
    • Andrea Dotta
    • Matteo Luciani
  • View Affiliations / Copyright

    Affiliations: Department of Neonatology, Bambino Gesù Children's Hospital, I‑00165 Rome, Italy, Department of Genetic Laboratories, Bambino Gesù Children's Hospital, I‑00165 Rome, Italy, Department of Hematology, Bambino Gesù Children's Hospital, I‑00165 Rome, Italy
    Copyright: © Salvatori et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 191-195
    |
    Published online on: November 21, 2016
       https://doi.org/10.3892/ol.2016.5401
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Abstract

Congenital leukemia is rare disease with an incidence of one to five cases per million births. Transient abnormal myelopoiesis (TAM), also called transient myeloproliferative disorder, is a pre‑leukemia disorder that may occur in Down syndrome (DS) or non‑DS infants. TAM may enter spontaneous remission; however, continual monitoring is required, as this disorder has been observed to develop into acute megakaryoblastic leukemia in 16‑30% of cases. In the literature, 16 cases of TAM in non‑DS infants have been reported. The case presented in the current study is, to the best of our knowledge, the first case of an Italian non‑DS newborn presenting with clinical manifestations of acute leukemia at five days after birth, exhibiting a normal karyotype, trisomy 21 only in blast cells, and spontaneous remission. Chromosomal analyses on peripheral blood cells, bone marrow cells and dermal fibroblasts were conducted using a G‑banding technique, and fluorescence in situ hybridization (FISH) was used to identify the critical regions of DS. Amplification of GATA binding protein 1 (GATA1) exon 2 genomic DNA was performed using polymerase chain reaction. Cytogenetic analysis of 50 peripheral blood cells and dermal fibroblasts from the patient revealed a normal karyotype: 46, XX. Conversely, cytogenetic analysis of the patient's bone marrow revealed an abnormal karyotype 47, XX+21. In order to investigate this result, FISH was performed, which identified the presence of three signals in 70% of the cells and two signals in 30% of bone marrow cells. GATA1 sequencing revealed the substitution of a single base (c.150delG) in exon 2. Seven months after the initial analysis, FISH and cytogenetic analyses of the stimulated/unstimulated peripheral blood cells and bone marrow cells were performed, revealing that each exhibited diploid signals, as observed in a normal karyotype.
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Copy and paste a formatted citation
Spandidos Publications style
Salvatori G, Foligno S, Sirleto P, Genovese S, Russo S, Coletti V, Dotta A and Luciani M: Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis. Oncol Lett 13: 191-195, 2017.
APA
Salvatori, G., Foligno, S., Sirleto, P., Genovese, S., Russo, S., Coletti, V. ... Luciani, M. (2017). Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis. Oncology Letters, 13, 191-195. https://doi.org/10.3892/ol.2016.5401
MLA
Salvatori, G., Foligno, S., Sirleto, P., Genovese, S., Russo, S., Coletti, V., Dotta, A., Luciani, M."Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis". Oncology Letters 13.1 (2017): 191-195.
Chicago
Salvatori, G., Foligno, S., Sirleto, P., Genovese, S., Russo, S., Coletti, V., Dotta, A., Luciani, M."Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis". Oncology Letters 13, no. 1 (2017): 191-195. https://doi.org/10.3892/ol.2016.5401
Copy and paste a formatted citation
x
Spandidos Publications style
Salvatori G, Foligno S, Sirleto P, Genovese S, Russo S, Coletti V, Dotta A and Luciani M: Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis. Oncol Lett 13: 191-195, 2017.
APA
Salvatori, G., Foligno, S., Sirleto, P., Genovese, S., Russo, S., Coletti, V. ... Luciani, M. (2017). Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis. Oncology Letters, 13, 191-195. https://doi.org/10.3892/ol.2016.5401
MLA
Salvatori, G., Foligno, S., Sirleto, P., Genovese, S., Russo, S., Coletti, V., Dotta, A., Luciani, M."Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis". Oncology Letters 13.1 (2017): 191-195.
Chicago
Salvatori, G., Foligno, S., Sirleto, P., Genovese, S., Russo, S., Coletti, V., Dotta, A., Luciani, M."Sometimes it is better to wait: First Italian case of a newborn with transient abnormal myelopoiesis and a favorable prognosis". Oncology Letters 13, no. 1 (2017): 191-195. https://doi.org/10.3892/ol.2016.5401
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