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Correlation between liver cancer pain and the HIF-1 and VEGF expression levels

  • Authors:
    • Geng Zhang
    • Gui-Yin Feng
    • Yan-Ru Guo
    • Dong-Qi Liang
    • Yuan Yuan
    • Hai-Lun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pain, Cangzhou Central Hospital, Cangzhou, Hebei 061001, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 77-80
    |
    Published online on: November 21, 2016
       https://doi.org/10.3892/ol.2016.5405
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Abstract

A possible correlation between liver cancer pain and the hypoxia-inducible factor (HIF)-1 and vascular endothelial growth factor (VEGF) expression levels was examined. From January, 2015 to January, 2016, 30 patients suffering from liver cancer with pain, 30 patients with liver cancer without pain and 30 hepatitis patients with pain were enrolled in the study. Pain level was evaluated by visual analogue scale (VAS), the expression levels of HIF-1 and VEGF mRNA were determined by RT-PCR and the expression levels of HIF-1 and VEGF proteins were examined by ELISA. Before intervention, the VAS in the hepatitis group was significantly higher than that of the liver cancer pain group. However, after intervention the VAS in the two groups was reduced. HIF-1 and VEGF mRNA expression levels in the liver cancer pain group were significantly higher than those in the liver cancer group before and after intervention. The expression levels of HIF-1 and VEGF mRNA in the hepatitis group were the lowest. The expression levels of HIF-1 and VEGF mRNA in the liver cancer pain group considerably increased after intervention. The expression levels of HIF-1 and VEGF mRNA in the other two groups showed no changes before or after intervention. Before and after the intervention, VAS in the liver cancer pain group was positively correlated to the expression levels of HIF-1 and VEGF. Thus, pain occurrence and the pain level in liver cancer patients were correlated with the expression levels of HIF-1 and VEGF. As the regular three‑step medicine analgesic ladder is ineffective in these cases, verification of HIF-1 and VEGF expression levels may be considered the new target for pain release.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang G, Feng G, Guo Y, Liang D, Yuan Y and Wang H: Correlation between liver cancer pain and the HIF-1 and VEGF expression levels. Oncol Lett 13: 77-80, 2017.
APA
Zhang, G., Feng, G., Guo, Y., Liang, D., Yuan, Y., & Wang, H. (2017). Correlation between liver cancer pain and the HIF-1 and VEGF expression levels. Oncology Letters, 13, 77-80. https://doi.org/10.3892/ol.2016.5405
MLA
Zhang, G., Feng, G., Guo, Y., Liang, D., Yuan, Y., Wang, H."Correlation between liver cancer pain and the HIF-1 and VEGF expression levels". Oncology Letters 13.1 (2017): 77-80.
Chicago
Zhang, G., Feng, G., Guo, Y., Liang, D., Yuan, Y., Wang, H."Correlation between liver cancer pain and the HIF-1 and VEGF expression levels". Oncology Letters 13, no. 1 (2017): 77-80. https://doi.org/10.3892/ol.2016.5405
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang G, Feng G, Guo Y, Liang D, Yuan Y and Wang H: Correlation between liver cancer pain and the HIF-1 and VEGF expression levels. Oncol Lett 13: 77-80, 2017.
APA
Zhang, G., Feng, G., Guo, Y., Liang, D., Yuan, Y., & Wang, H. (2017). Correlation between liver cancer pain and the HIF-1 and VEGF expression levels. Oncology Letters, 13, 77-80. https://doi.org/10.3892/ol.2016.5405
MLA
Zhang, G., Feng, G., Guo, Y., Liang, D., Yuan, Y., Wang, H."Correlation between liver cancer pain and the HIF-1 and VEGF expression levels". Oncology Letters 13.1 (2017): 77-80.
Chicago
Zhang, G., Feng, G., Guo, Y., Liang, D., Yuan, Y., Wang, H."Correlation between liver cancer pain and the HIF-1 and VEGF expression levels". Oncology Letters 13, no. 1 (2017): 77-80. https://doi.org/10.3892/ol.2016.5405
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