Open Access

Different but synergistic effects of bone marrow‑derived VEGFR2+ and VEGFR2‑CD45+ cells during hepatocellular carcinoma progression

  • Authors:
    • Xiaolin Zhu
    • Hongyuan Zhou
    • Jingtao Luo
    • Yunlong Cui
    • Huikai Li
    • Wei Zhang
    • Feng Fang
    • Qiang Li
    • Ti Zhang
  • View Affiliations

  • Published online on: November 22, 2016     https://doi.org/10.3892/ol.2016.5411
  • Pages: 63-68
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer‑associated mortality worldwide in men. Bone marrow‑derived cells (BMDCs), including circulating endothelial progenitor cells, have been reported to be involved in the progression of HCC. The complexity of BMDCs inspires further interest in the study of HCC. In the present study, highly metastatic HCC models with BM function deficiency/reconstruction were established by sublethal irradiation/BM transplantation. The effects of vascular endothelial growth factor receptor‑2 (VEGFR2)+ or VEGFR2‑/cluster of differentiation 45 (CD45)+ BMDCs on HCC growth were evaluated. VEGFR2+ and VEGFR2‑CD45+ BMDCs facilitated the recovery of BM function and promoted tumor growth, while the enhancement of tumor growth by VEGFR2‑CD45+ BMDCs was independent of VEGFR2+ BMDCs. BM‑derived CD45+CD133+ and VEGFR2+CD133+ cells synergistically played a role in the different stages during HCC progression. In conclusion, different types of BMDCs exhibit effects on HCC tumor growth in a coordinated manner.
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January-2017
Volume 13 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhu X, Zhou H, Luo J, Cui Y, Li H, Zhang W, Fang F, Li Q and Zhang T: Different but synergistic effects of bone marrow‑derived VEGFR2+ and VEGFR2‑CD45+ cells during hepatocellular carcinoma progression. Oncol Lett 13: 63-68, 2017
APA
Zhu, X., Zhou, H., Luo, J., Cui, Y., Li, H., Zhang, W. ... Zhang, T. (2017). Different but synergistic effects of bone marrow‑derived VEGFR2+ and VEGFR2‑CD45+ cells during hepatocellular carcinoma progression. Oncology Letters, 13, 63-68. https://doi.org/10.3892/ol.2016.5411
MLA
Zhu, X., Zhou, H., Luo, J., Cui, Y., Li, H., Zhang, W., Fang, F., Li, Q., Zhang, T."Different but synergistic effects of bone marrow‑derived VEGFR2+ and VEGFR2‑CD45+ cells during hepatocellular carcinoma progression". Oncology Letters 13.1 (2017): 63-68.
Chicago
Zhu, X., Zhou, H., Luo, J., Cui, Y., Li, H., Zhang, W., Fang, F., Li, Q., Zhang, T."Different but synergistic effects of bone marrow‑derived VEGFR2+ and VEGFR2‑CD45+ cells during hepatocellular carcinoma progression". Oncology Letters 13, no. 1 (2017): 63-68. https://doi.org/10.3892/ol.2016.5411