Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2017 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2017 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2

  • Authors:
    • Tomohiro Matsuo
    • Yasuyoshi Miyata
    • Kensuke Mitsunari
    • Takuji Yasuda
    • Kojiro Ohba
    • Hideki Sakai
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8501, Japan
  • Pages: 275-280
    |
    Published online on: November 22, 2016
       https://doi.org/10.3892/ol.2016.5416
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Heme oxygenase 1 (HO-1) is a stress‑response protein and its expression is associated with malignant potential and poor prognosis in several types of cancer. The present study investigated the association between HO‑1 expression levels and the pathological features, clinical outcomes and other associated factors in patients with non‑muscle‑invasive bladder cancer (NMIBC). HO‑1 expression was evaluated using immunohistochemistry in 147 formalin‑fixed tissue specimens. The proliferation index, microvessel density, lymph vessel density and expression of cyclooxygenase (COX)‑2 and vascular endothelial growth factor (VEGF)‑A, ‑C, and ‑D were also investigated. Correlations among variables were analyzed by multivariate analysis. Survival was assessed using Kaplan‑Meier survival curves and multivariate statistics. HO‑1 expression levels in high‑grade and pT1 tumors were significantly higher compared with low‑grade and pTa tumors, and were correlated with the proliferation index (P<0.001), lymph vessel density (P=0.021) and COX‑2 expression levels (P=0.003). The proliferation index and COX‑2 expression levels were also identified as independent contributing factors in multivariate models. Kaplan‑Meier survival curves associated HO‑1 expression with a poor prognosis in metastasis‑free (P=0.047) and cause‑specific survival (P=0.017), but not with urinary tract recurrence (P=0.231). Furthermore, HO‑1 expression was identified by multivariate analysis to be a significant predictor for cause‑specific survival (hazard ratio, 4.08; 95% confidence interval, 1.06‑15.66; P=0.004). HO‑1 has an important role in the malignant aggressiveness of NMIBC and its expression is associated with cause‑specific survival. HO‑1‑associated activities are regulated by cancer cell proliferation, lymphangiogenesis and COX‑2. The results suggest that HO‑1 may be a potential therapeutic target and a useful predictive prognostic factor in patients with NMIBC.
View Figures

Figure 1

Figure 2

View References

1 

Sylvester RJ, van der Meijden AP, Oosterlinck W, Witjes JA, Bouffioux C, Denis L, Newling DW and Kurth K: Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: A combined analysis of 2596 patients from seven EORTC trials. Eur Urol. 49:466–477. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Cookson MS, Herr HW, Zhang ZF, Soloway S, Sogani PC and Fair WR: The treated natural history of high risk superficial bladder cancer: 15-year outcome. J Urol. 158:62–67. 1997. View Article : Google Scholar : PubMed/NCBI

3 

van Rhijn BW, Burger M, Lotan Y, Solsona E, Stief CG, Sylvester RJ, Witjes JA and Zlotta AR: Recurrence and progression of disease in non-muscle-invasive bladder cancer: From epidemiology to treatment strategy. Eur Urol. 56:430–442. 2009. View Article : Google Scholar : PubMed/NCBI

4 

D'Costa JJ, Goldsmith JC, Wilson JS, Bryan RT and Ward DG: A systematic review of the diagnostic and prognostic value of urinary protein biomarkers in Urothelial bladder cancer. Bladder Cancer. 2:301–317. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Pospisilova S, Pazourkova E, Horinek A, Brisuda A, Svobodova I, Soukup V, Hrbacek J, Capoun O, Hanus T, Mares J, et al: MicroRNAs in urine supernatant as potential non-invasive markers for bladder cancer detection. Neoplasma. 63:799–808. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Miyata Y, Kanda S, Ohba K, Nomata K, Hayashida Y, Eguchi J, Hayashi T and Kanetake H: Lymphangiogenesis and angiogenesis in bladder cancer: Prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D. Clin Cancer Res. 12:800–806. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Ding W, Gou Y, Sun C, Xia G, Wang H, Chen Z, Tan J, Xu K and Qiang D: Ki-67 is an independent indicator in non-muscle invasive bladder cancer (NMIBC); combination of EORTC risk scores and Ki-67 expression could improve the risk stratification of NMIBC. Urol Oncol. 32:42.e13–e19. 2014. View Article : Google Scholar

8 

Miyata Y, Watanabe S, Sagara Y, Mitsunari K, Matsuo T, Ohba K and Sakai H: High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer. PLoS One. 8:e590952013. View Article : Google Scholar : PubMed/NCBI

9 

Wang W, Jiang H, Zhu H, Zhang H, Gong J, Zhang L and Ding Q: Overexpression of high mobility group box 1 and 2 is associated with the progression and angiogenesis of human bladder carcinoma. Oncol Lett. 5:884–888. 2013.PubMed/NCBI

10 

Tenhunen R, Marver HS and Schmid R: The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA. 61:748–755. 1968. View Article : Google Scholar : PubMed/NCBI

11 

Applegate LA, Luscher P and Tyrrell RM: Induction of heme oxygenase: A general response to oxidant stress in cultured mammalian cells. Cancer Res. 51:974–978. 1991.PubMed/NCBI

12 

Fang J, Akaike T and Maeda H: Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis. 9:27–35. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Lane D, Gray EA, Mathur RS and Mathur SP: Up-regulation of vascular endothelial growth factor-C by nicotine in cervical cancer cell lines. Am J Reprod Immnol. 53:153–158. 2005. View Article : Google Scholar

14 

Degese MS, Mendizabal JE, Gandini NA, Gutkind JS, Molinolo A, Hewitt SM, Curino AC, Coso OA and Facchinetti MM: Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. Lung Cancer. 77:168–175. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Was H, Cichon T, Smolarczyk R, Rudnicka D, Stopa M, Chevalier C, Leger JJ, Lackowska B, Grochot A, Bojkowska K, et al: Overexpression of heme oxygenase-1 in murine melanoma: Increased proliferation and viability of tumor cells, decreased survival of mice. Am J Pathol. 169:2181–2198. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Ferrando M, Gueron G, Elguero B, Giudice J, Salles A, Leskow FC, Jares-Erijman EA, Colombo L, Meiss R, Navone N, et al: Heme oxygenase 1 (HO-1) challenges the angiogenic switch in prostate cancer. Angiogenesis. 14:467–479. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Miyata Y, Kanda S, Mitsunari K, Asai A and Sakai H: Heme oxygenase-1 expression is associated with tumor aggressiveness and outcomes in patients with bladder cancer: A correlation with smoking intensity. Transl Res. 164:468–476. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Kopparapu PK, Boorjian SA, Robinson BD, Downes M, Gudas LJ, Mongan NP and Persson JL: Expression of VEGF and its receptors VEGFR1/VEGFR2 is associated with invasiveness of bladder cancer. Anticancer Res. 33:2381–2390. 2013.PubMed/NCBI

19 

Sobin DH and Wittekind CH: TNM Classification of Malignant Tumours. 6th. Wiley-Liss; New York: pp. 199–202. 2002

20 

Sauter G, Algaba F, Amin MB, Busch C, Cheville J, Gasser T, Grignon DJ, Hofstädter F, Lopez-Beltran A and Epstein JI: Non-invasive urothelial tumoursWorld Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organ. Eble JN, Sauter G, Epstein JI and Sesterhenn IA: IARC Press; Lyon, France: pp. 110–123. 2004

21 

Miyata Y, Kanda S, Ohba K, Nomata K, Eguchi J, Hayashida Y and Kanetake H: Tumor lymphangiogenesis in transitional cell carcinoma of the upper urinary tract: Association with clinicopathological features and prognosis. J Urol. 176:348–353. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Miyata Y, Koga S, Kanda S, Nishikido M, Hayashi T and Kanetake H: Expression of cyclooxygenase-2 in renal cell carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. Clin Cancer Res. 9:1741–1749. 2003.PubMed/NCBI

23 

Miyata Y, Kanda S, Nomata K, Hayashida Y and Kanetake H: Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: Correlation with tumor stage and survival. Urology. 63:602–608. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Gandini NA, Fermento ME, Salomón DG, Blasco J, Patel V, Gutkind JS, Molinolo AA, Facchinetti MM and Curino AC: Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. Exp Mol Pathol. 93:237–245. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Banerjee P, Basu A, Wegiel B, Otterbein LE, Mizumura K, Gasser M, Waaga-Gasser AM, Choi AM and Pal S: Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis- and autophagy-regulating molecules. J Biol Chem. 287:32113–32123. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Yin Y, Liu Q, Wang B, Chen G, Xu L and Zhou H: Expression and function of heme oxygenase-1 in human gastric cancer. Exp Biol Med (Maywood). 237:362–371. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Andrés NC, Fermento ME, Gandini NA, Romero AL, Ferro A, Donna LG, Curino AC and Facchinetti MM: Heme oxygenase-1 has antitumoral effects in colorectal cancer: Involvement of p53. Exp Mol Pathol. 97:321–331. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Yanagawa T, Omura K, Harada H, Nakaso K, Iwasa S, Koyama Y, Onizawa K, Yusa H and Yoshida H: Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas. Oral Oncol. 40:21–27. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Miyake M, Fujimoto K, Anai S, Ohnishi S, Kuwada M, Nakai Y, Inoue T, Matsumura Y, Tomioka A, Ikeda T, et al: Heme oxygenase-1 promotes angiogenesis in urothelial carcinoma of the urinary bladder. Oncol Rep. 25:653–660. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Yim MS, Ha YS, Kim IY, Yun SJ, Choi YH and Kim WJ: HMOX1 is an important prognostic indicator of nonmuscle invasive bladder cancer recurrence and progression. J Urol. 185:701–705. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Miyake M, Fujimoto K, Anai S, Ohnishi S, Nakai Y, Inoue T, Matsumura Y, Tomioka A, Ikeda T, Tanaka N and Hirao Y: Clinical significance of heme oxygenase-1 expression in non-muscle invasive bladder cancer. Urol Int. 85:355–363. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Kim JH and Park J: Prognostic significance of heme oxygenase-1, S100 calcium-binding protein A4, and syndecan-1 expression in primary non-muscle-invasive bladder cancer. Hum Pathol. 45:1830–1838. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Miyake M, Ishii M, Kawashima K, Kodama T, Sugano K, Fujimoto K and Hirao Y: siRNA-mediated knockdown of the heme synthesis and degradation pathways: Modulation of treatment effect of 5-aminolevulinic acid-based photodynamic therapy in urothelial cancer cell lines. Photochem Photobiol. 85:1020–1027. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Lin H, Huang BR, Yeh WL, Lee CH, Huang SS, Lai CH, Lin H and Lu DY: Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways. Neurobiol Aging. 35:191–202. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Lin HH, Chiang MT, Chang PC and Chau LY: Myeloid heme oxygenase-1 promotes metastatic tumor colonization in mice. Cancer Sci. 106:299–306. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Matsuo T, Miyata Y, Mitsunari K, Yasuda T, Ohba K and Sakai H: Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2. Oncol Lett 13: 275-280, 2017.
APA
Matsuo, T., Miyata, Y., Mitsunari, K., Yasuda, T., Ohba, K., & Sakai, H. (2017). Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2. Oncology Letters, 13, 275-280. https://doi.org/10.3892/ol.2016.5416
MLA
Matsuo, T., Miyata, Y., Mitsunari, K., Yasuda, T., Ohba, K., Sakai, H."Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2". Oncology Letters 13.1 (2017): 275-280.
Chicago
Matsuo, T., Miyata, Y., Mitsunari, K., Yasuda, T., Ohba, K., Sakai, H."Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2". Oncology Letters 13, no. 1 (2017): 275-280. https://doi.org/10.3892/ol.2016.5416
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuo T, Miyata Y, Mitsunari K, Yasuda T, Ohba K and Sakai H: Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2. Oncol Lett 13: 275-280, 2017.
APA
Matsuo, T., Miyata, Y., Mitsunari, K., Yasuda, T., Ohba, K., & Sakai, H. (2017). Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2. Oncology Letters, 13, 275-280. https://doi.org/10.3892/ol.2016.5416
MLA
Matsuo, T., Miyata, Y., Mitsunari, K., Yasuda, T., Ohba, K., Sakai, H."Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2". Oncology Letters 13.1 (2017): 275-280.
Chicago
Matsuo, T., Miyata, Y., Mitsunari, K., Yasuda, T., Ohba, K., Sakai, H."Pathological significance and prognostic implications of heme oxygenase 1 expression in non‑muscle‑invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX‑2". Oncology Letters 13, no. 1 (2017): 275-280. https://doi.org/10.3892/ol.2016.5416
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team