Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation stages in craniopharyngioma

Sun,Fenglei; Sun,Xintang; Du,Xiaolong; Xing,Hongshun; Yang,Bin

doi:10.3892/ol.2016.5418

January-2017 Volume 13 Issue 1

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January-2017 Volume 13 Issue 1

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Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation stages in craniopharyngioma

Authors:
- Fenglei Sun
- Xintang Sun
- Xiaolong Du
- Hongshun Xing
- Bin Yang
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China, Department of Food and Pharmaceutical Science and Technology, Shandong Vocational Animal Science and Veterinary College, Weifang, Shandong 261061, P.R. China, Department of Neurosurgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China

Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 250-252
|
Published online on: November 22, 2016

https://doi.org/10.3892/ol.2016.5418
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Abstract

Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation periods in craniopharyngioma cases were examined. Twenty patients who underwent tumor resection from January 2012 to January 2015 were included in the study. We monitored factors related to endocrine changes and hormone substitution treatment during pre‑ and post‑operation periods. Blood thyroid-stimulating hormone, triiodothyronine, thyroxine, prolactin, follicle-stimulating hormone, luteinizing hormone and cortisol levels were measured in the patients. Urinary volume and urine specific gravity were also measured before and after the operation. After the operation, we observed diabetes insipidus and a decrease in TSH and gonadal hormone levels more frequently compared to pre‑operation. However, incidence of high prolactin was markedly reduced following surgery. The number of hypothyroidism cases before and after surgery had no statistical significance. In conclusion, surgery for craniopharyngioma aggravated endocrine dysfunction. Craniotomy and total tumor resection had considerable effects on the endocrine system. Routine hormone therapy as an alternative treatment was necessary after operation. Alternative treatment of adrenal cortex hormones reduced the incidence on low blood cortisol.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Factors related to endocrine changes and hormone substitution treatment during pre- and post-operation stages in craniopharyngioma

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