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Article

Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro

  • Authors:
    • Jingling Tang
    • Hongyu Ji
    • Jinmei Ren
    • Mengting Li
    • Nannan Zheng
    • Linhua Wu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutics, School of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Key Laboratory of Medications Research, College of Heilongjiang Province, Harbin, Heilongjiang 150086, P.R. China
  • Pages: 389-395
    |
    Published online on: November 23, 2016
       https://doi.org/10.3892/ol.2016.5421
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Abstract

Multidrug resistance (MDR) is a main clinical hurdle for chemotherapy of cancer, and overexpression of P-glycoprotein (P-gp) is a key factor. In the present study, a new co‑delivery system for reversing MDR was designed and developed. The system was composed of curcumin (Cur) and piperine (Pip) encapsulated in solid lipid nanoparticles (SLNs) with tocopheryl polyethylene glycol succinate (TPGS) and Brij 78 [(Cur+Pip)‑SLNs]. TPGS and Brij 78 could sensitize MDR tumors by inhibiting the P‑gp drug efflux system. The combination of Cur and Pip, when administered in SLNs formulations, resulted in a significant enhancement in cytotoxicity and allowed efficient intracellular delivery of the drugs in drug‑resistant A2780/Taxol cells. This dual inhibitory strategy may have significant potential in the clinical management of MDR in cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Tang J, Ji H, Ren J, Li M, Zheng N and Wu L: Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro. Oncol Lett 13: 389-395, 2017.
APA
Tang, J., Ji, H., Ren, J., Li, M., Zheng, N., & Wu, L. (2017). Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro. Oncology Letters, 13, 389-395. https://doi.org/10.3892/ol.2016.5421
MLA
Tang, J., Ji, H., Ren, J., Li, M., Zheng, N., Wu, L."Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro". Oncology Letters 13.1 (2017): 389-395.
Chicago
Tang, J., Ji, H., Ren, J., Li, M., Zheng, N., Wu, L."Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro". Oncology Letters 13, no. 1 (2017): 389-395. https://doi.org/10.3892/ol.2016.5421
Copy and paste a formatted citation
x
Spandidos Publications style
Tang J, Ji H, Ren J, Li M, Zheng N and Wu L: Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro. Oncol Lett 13: 389-395, 2017.
APA
Tang, J., Ji, H., Ren, J., Li, M., Zheng, N., & Wu, L. (2017). Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro. Oncology Letters, 13, 389-395. https://doi.org/10.3892/ol.2016.5421
MLA
Tang, J., Ji, H., Ren, J., Li, M., Zheng, N., Wu, L."Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro". Oncology Letters 13.1 (2017): 389-395.
Chicago
Tang, J., Ji, H., Ren, J., Li, M., Zheng, N., Wu, L."Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro". Oncology Letters 13, no. 1 (2017): 389-395. https://doi.org/10.3892/ol.2016.5421
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