Open Access

C‑type lectins facilitate tumor metastasis (Review)

  • Authors:
    • Dongbing Ding
    • Yao Yao
    • Songbai Zhang
    • Chunjie Su
    • Yonglian Zhang
  • View Affiliations

  • Published online on: November 24, 2016     https://doi.org/10.3892/ol.2016.5431
  • Pages: 13-21
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metastasis, a life-threatening complication of cancer, leads to the majority of cases of cancer‑associated mortality. Unfortunately, the underlying molecular and cellular mechanisms of cancer metastasis remain to be fully elucidated. C‑type lectins are a large group of proteins, which share structurally homologous carbohydrate‑recognition domains (CRDs) and possess diverse physiological functions, including inflammation and antimicrobial immunity. Accumulating evidence has demonstrated the contribution of C‑type lectins in different steps of the metastatic spread of cancer. Notably, a substantial proportion of C‑type lectins, including selectins, mannose receptor (MR) and liver and lymph node sinusoidal endothelial cell C‑type lectin, are important molecular targets for the formation of metastases in vitro and in vivo. The present review summarizes what has been found regarding C‑type lectins in the lymphatic and hematogenous metastasis of cancer. An improved understanding the role of C‑type lectins in cancer metastasis provides a comprehensive perspective for further clarifying the molecular mechanisms of cancer metastasis and supports the development of novel C‑type lectins‑based therapies the for prevention of metastasis in certain types of cancer.
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January-2017
Volume 13 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Ding D, Yao Y, Zhang S, Su C and Zhang Y: C‑type lectins facilitate tumor metastasis (Review). Oncol Lett 13: 13-21, 2017
APA
Ding, D., Yao, Y., Zhang, S., Su, C., & Zhang, Y. (2017). C‑type lectins facilitate tumor metastasis (Review). Oncology Letters, 13, 13-21. https://doi.org/10.3892/ol.2016.5431
MLA
Ding, D., Yao, Y., Zhang, S., Su, C., Zhang, Y."C‑type lectins facilitate tumor metastasis (Review)". Oncology Letters 13.1 (2017): 13-21.
Chicago
Ding, D., Yao, Y., Zhang, S., Su, C., Zhang, Y."C‑type lectins facilitate tumor metastasis (Review)". Oncology Letters 13, no. 1 (2017): 13-21. https://doi.org/10.3892/ol.2016.5431