Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2017 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2017 Volume 13 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

C‑type lectins facilitate tumor metastasis (Review)

  • Authors:
    • Dongbing Ding
    • Yao Yao
    • Songbai Zhang
    • Chunjie Su
    • Yonglian Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Jingmen First People's Hospital, Jingmen, Hubei 448000, P.R. China, Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 13-21
    |
    Published online on: November 24, 2016
       https://doi.org/10.3892/ol.2016.5431
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Metastasis, a life-threatening complication of cancer, leads to the majority of cases of cancer‑associated mortality. Unfortunately, the underlying molecular and cellular mechanisms of cancer metastasis remain to be fully elucidated. C‑type lectins are a large group of proteins, which share structurally homologous carbohydrate‑recognition domains (CRDs) and possess diverse physiological functions, including inflammation and antimicrobial immunity. Accumulating evidence has demonstrated the contribution of C‑type lectins in different steps of the metastatic spread of cancer. Notably, a substantial proportion of C‑type lectins, including selectins, mannose receptor (MR) and liver and lymph node sinusoidal endothelial cell C‑type lectin, are important molecular targets for the formation of metastases in vitro and in vivo. The present review summarizes what has been found regarding C‑type lectins in the lymphatic and hematogenous metastasis of cancer. An improved understanding the role of C‑type lectins in cancer metastasis provides a comprehensive perspective for further clarifying the molecular mechanisms of cancer metastasis and supports the development of novel C‑type lectins‑based therapies the for prevention of metastasis in certain types of cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Chaffer CL and Weinberg RA: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Chambers AF, Groom AC and MacDonald IC: Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer. 2:563–572. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Alitalo K, Tammela T and Petrova TV: Lymphangiogenesis in development and human disease. Nature. 438:946–953. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Fidler IJ: The pathogenesis of cancer metastasis: The ‘seed and soil’ hypothesis revisited. Nat Rev Cancer. 3:453–458. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Läubli H and Borsig L: Selectins promote tumor metastasis. Semin Cancer Biol. 20:169–177. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Arabzadeh A, Chan C, Nouvion AL, Breton V, Benlolo S, DeMarte L, Turbide C, Brodt P, Ferri L and Beauchemin N: Host-related carcinoembryonic antigen cell adhesion molecule 1 promotes metastasis of colorectal cancer. Oncogene. 32:849–860. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Desgrosellier JS and Cheresh DA: Integrins in cancer: Biological implications and therapeutic opportunities. Nat Rev Cancer. 10:9–22. 2010. View Article : Google Scholar : PubMed/NCBI

8 

van Gisbergen KP, Aarnoudse CA, Meijer GA, Geijtenbeek TB and van Kooyk Y: Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin. Cancer Res. 65:5935–5944. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Jiang Y, Zhang C, Chen K, Chen Z, Sun Z, Zhang Z, Ding D, Ren S and Zuo Y: The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer. PLoS One. 9:e1147482014. View Article : Google Scholar : PubMed/NCBI

10 

Zuo Y, Ren S, Wang M, Liu B, Yang J, Kuai X, Lin C, Zhao D, Tang L and He F: Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in vivo metastasis to the liver. Gut. 62:1169–1178. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Kannagi R, Izawa M, Koike T, Miyazaki K and Kimura N: Carbohydrate-mediated cell adhesion in cancer metastasis and angiogenesis. Cancer Sci. 95:377–384. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Feinberg H, Mitchell DA, Drickamer K and Weis WI: Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Science. 294:2163–2166. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Kansas GS: Selectins and their ligands: Current concepts and controversies. Blood. 88:3259–3287. 1996.PubMed/NCBI

14 

Martinez-Pomares L: The mannose receptor. J Leukoc Biol. 92:1177–1186. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Mitchell DA, Fadden AJ and Drickamer K: A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. J Biol Chem. 276:28939–28945. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Zarbock A, Ley K, McEver RP and Hidalgo A: Leukocyte ligands for endothelial selectins: Specialized glycoconjugates that mediate rolling and signaling under flow. Blood. 118:6743–6751. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Pals ST, de Gorter DJ and Spaargaren M: Lymphoma dissemination: The other face of lymphocyte homing. Blood. 110:3102–3111. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Qian F, Hanahan D and Weissman IL: L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis. Proc Natl Acad Sci USA. 98:3976–3981. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Sperandio M: Selectins and glycosyltransferases in leukocyte rolling in vivo. FEBS J. 273:4377–4389. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Girard JP, Moussion C and Förster R: HEV, lymphatics and homeostatic immune cell trafficking in lymph nodes. Nat Rev Immunol. 12:762–773. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Irjala H, Johansson EL, Grenman R, Alanen K, Salmi M and Jalkanen S: Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium. J Exp Med. 194:1033–1042. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Zuo Y, Wei W, Liu C, Zhao L, Wang L and Zhang J: Silencing L-selectin expression by siRNA attenuated metastasis of murine lymphoid neoplasm cell P388D1 to peripheral lymph nodes. Leukemia. 21:180–183. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Wei W, Zuo Y, Hu Y, Wang L, Jia L and Zhang J: Heparin inhibits P388D1 cells adherence and metastasis to peripheral lymph nodes in vitro and in vivo. Lymphology. 42:10–18. 2009.PubMed/NCBI

24 

Aviram R, Raz N, Kukulansky T and Hollander N: Expression of L-selectin and efficient binding to high endothelial venules do not modulate the dissemination potential of murine B-cell lymphoma. Cancer Immunol Immunother. 50:61–68. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Wei J, Cui L, Liu F, Fan Y, Lang R, Gu F, Guo X, Tang P and Fu L: E-selectin and Sialyl Lewis X expression is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast. Int J Surg Pathol. 18:193–200. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Gay LJ and Felding-Habermann B: Contribution of platelets to tumour metastasis. Nat Rev Cancer. 11:123–134. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Gout S, Tremblay PL and Huot J: Selectins and selectin ligands in extravasation of cancer cells and organs electivity of metastasis. Clin Exp Metastasis. 25:335–344. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Tomlinson J, Wang JL, Barsky SH, Lee MC, Bischoff J and Nguyen M: Human colon cancer cells express multiple glycoprotein ligands for E-selecin. Int J Oncol. 16:347–353. 2000.PubMed/NCBI

29 

Khatib AM, Fallavollita L, Wancewicz EV, Monia BP and Brodt P: Inhibition of hepatic endothelial E-selectin expression by C-raf antisense oligonucleotides blocks colorectal carcinoma liver metastasis. Cancer Res. 62:5393–5398. 2002.PubMed/NCBI

30 

Khatib AM, Kontogiannea M, Fallavollita L, Jamison B, Meterissian S and Brodt P: Rapid induction of cytokine and E-selectin expression in the liver in response to metastatic tumor cells. Cancer Res. 59:1356–1361. 1999.PubMed/NCBI

31 

Hanley WD, Burdick MM, Konstantopoulos K and Sackstein R: CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity. Cancer Res. 65:5812–5817. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Burdick MM, Chu JT, Godar S and Sackstein R: HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells. J Biol Chem. 281:13899–13905. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Brodt P, Fallavollita L, Bresalier RS, Meterissian S, Norton CR and Wolitzky BA: Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis. Int J Cancer. 71:612–619. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Köhler S, Ullrich S, Richter U and Schumacher U: E-/P-selectins and colon carcinoma metastasis: First in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung. Br J Cancer. 102:602–609. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Zen K, Liu DQ, Guo YL, Wang C, Shan J, Fang M, Zhang CY and Liu Y: CD44v4 is a major E-selectin ligand that mediates breast cancer cell transendothelial migration. PLoS One. 3:e18262008. View Article : Google Scholar : PubMed/NCBI

36 

Shirure VS, Henson KA, Schnaar RL, Nimrichter L and Burdick MM: Gangliosiedes expressed on breast cancer cells are E-selectin ligands. Biochem Biophys Res Commun. 406:423–429. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Shirure VS, Reynolds NM and Burdick MM: Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cell. PLoS One. 7:e445292012. View Article : Google Scholar : PubMed/NCBI

38 

Dimitroff CJ, Lechpammer M, Long-Woodward D and Kutok JL: Rolling of human bone-metastatic prostate tumor cells on human bone marrow endothelium under shear flow is mediated by E-selectin. Cancer Res. 64:5261–5269. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Yoshimoto K, Tajima H, Ohta T, Okamoto K, Sakai S, Kinoshita J, Furukawa H, Makino I, Hayashi H, Nakamura K, et al: Increased E-selectin in hepatic ischemia-reperfusion injury mediates liver metastasis of pancreatic cancer. Oncol Rep. 28:791–796. 2012.PubMed/NCBI

40 

Kobayashi K, Matsumoto S, Morishima T, Kawabe T and Okamoto T: Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression. Cancer Res. 60:3978–3984. 2000.PubMed/NCBI

41 

Raes G, Ghassabeh GH, Brys L, Mpofu N, Verschueren H, Vanhecke D and De Baetselier P: The metastatic T-cell hybridoma antigen/P-selectin glycoprotein ligand 1 is required for hematogenous metastasis of lymphomas. Int J Cancer. 121:2646–2652. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Aigner S, Sthoeger ZM, Fogel M, Weber E, Zarn J, Ruppert M, Zeller Y, Vestweber D, Stahel R, Sammar M and Altevogt P: CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells. Blood. 89:3385–3395. 1997.PubMed/NCBI

43 

Alves CS, Burdick MM, Thomas SN, Pawar P and Konstantopoulos K: The dual role of CD44 as a functional P selectin ligand and fibrin receptor in colon carcinoma cell adhesion. Am J Physiol Cell Physiol. 294:C907–C916. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Garcia J, Callewaert N and Borsig L: P-selectin mediates metastatic progression through binding to sulfatides on tumor cells. Glycobiology. 17:185–196. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Monzavi-Karbassi B, Stanley JS, Hennings L, Jousheghany F, Artaud C, Shaaf S and Kieber-Emmons T: Chondroitin sulfate glycosaminoglycans as major P-selectin ligands on metastatic breast cancer cell lines. Int J Cancer. 120:1179–1191. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Stone JP and Wagner DD: P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer. J Clin Invest. 92:804–813. 1993. View Article : Google Scholar : PubMed/NCBI

47 

Ludwig RJ, Boehme B, Podda M, Henschler R, Jager E, Tandi C, Boehncke WH, Zollner TM, Kaufmann R and Gille J: Endothelial P-selectin as a target of heparin action in experimental melanoma lung metastasis. Cancer Res. 64:2743–2750. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Kim YJ, Borsig L, Varki NM and Varki A: P-selectin deficiency attenuates tumor growth and metastasis. Proc Natl Acad Sci USA. 95:9325–9330. 1998. View Article : Google Scholar : PubMed/NCBI

49 

Chen JL, Chen WX, Zhu JS, Chen NW, Zhou T, Yao M, Zhang DQ and Wu YL: Effect of P-selectin monoclonal antibody on metastasis of gastric cancer and immune function. World J Gastroenterol. 9:1607–1610. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Wei M, Tai G, Gao Y, Li N, Huang B, Zhou Y, Hao S and Zeng X: Modified heparin inhibits P-selectin-mediated cell adhesion of human colon carcinoma cells to immobilized platelets under dynamic flow conditions. J Biol Chem. 279:29202–29210. 2004. View Article : Google Scholar : PubMed/NCBI

51 

Gao Y, Wei M, Zheng S, Ba X, Hao S and Zeng X: Chemically modified heparin inhibits the in vitro adhesion of nonsmall cell lung cancer cells to P-selectin. J Cancer Res Clin Oncol. 132:257–264. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Borsig L, Vlodavsky I, Ishai-Michaeli R, Torri G and Vismara E: Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase. Neoplasia. 13:445–452. 2011. View Article : Google Scholar : PubMed/NCBI

53 

Sperandio M, Smith ML, Forlow SB, Olson TS, Xia L, McEver RP and Ley K: P-selectin glycoprotein ligand-1 mediates L-selectin dependent leukocyte rolling in venules. J Exp Med. 197:1355–1363. 2003. View Article : Google Scholar : PubMed/NCBI

54 

Läubli H, Stevenson JL, Varki A, Varki NM and Borsig L: L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Cancer Res. 66:1536–1542. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Borsig L, Wong R, Hynes RO, Varki NM and Varki A: Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci USA. 99:2193–2198. 2002. View Article : Google Scholar : PubMed/NCBI

56 

Dallas MR, Chen SH, Streppel MM, Sharma S, Maitra A and Konstantopoulos K: Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells. Am J Physiol Cell Physiol. 303:C616–C624. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Hanley WD, Napier SL, Burdick MM, Schnaar RL, Sackstein R and Konstantopoulos K: Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells. FASEB J. 20:337–339. 2006.PubMed/NCBI

58 

Thomas SN, Zhu F, Schnaar RL, Alves CS and Konstantopoulos K: Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow. J Biol Chem. 283:15647–15655. 2008. View Article : Google Scholar : PubMed/NCBI

59 

Rivera-Calzada A, Robertson D, MacFadyen JR, Boskovic J, Isacke CM and Llorca O: Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180. EMBO Rep. 4:807–812. 2003. View Article : Google Scholar : PubMed/NCBI

60 

Jürgensen HJ, Madsen DH, Ingvarsen S, Melander MC, Gårdsvoll H, Patthy L, Engelholm LH and Behrendt N: A novel functional role of collagen glycosylation: Interaction with the endocytic receptor uPARAP/Endo180. J Biol Chem. 286:32736–32748. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Irjala H, Alanen K, Grénman R, Heikkilä P, Joensuu H and Jalkanen S: Mannose receptor (MR) and common lymphatic endothelial and vascular endothelial receptor (CLEVER)-1 direct the binding of cancer cells to the lymph vessel endothelium. Cancer Res. 63:4671–4676. 2003.PubMed/NCBI

62 

Marttila-Ichihara F, Turja R, Miiluniemi M, Karikoski M, Maksimow M, Niemelä J, Martinez-Pomares L, Salmi M and Jalkanen S: Macrophage mannose receptor on lymphatics controls cell trafficking. Blood. 112:64–72. 2008. View Article : Google Scholar : PubMed/NCBI

63 

Salmi M, Karikoski M, Elima K, Rantakari P and Jalkanen S: CD44 binds to macrophage mannose receptor on lymphatic endothelium and supports lymphocyte migration via afferent lymphatics. Circ Res. 112:1577–1582. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Götte M and Yip GW: Heparanase, hyaluronan, and CD44 in cancers: A breast carcinoma perspective. Cancer Res. 66:10233–10237. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Wielenga VJ, van der Neut R, Offerhaus GJ and Pals ST: CD44 glycoproteins in colorectal cancer: Expression, function, and prognostic value. Adv Cancer Res. 77:169–187. 2000. View Article : Google Scholar : PubMed/NCBI

66 

Leung EL, Fiscus RR, Tung JW, Tin VP, Cheng LC, Sihoe AD, Fink LM, Ma Y and Wong MP: Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties. PLoS One. 5:e140622010. View Article : Google Scholar : PubMed/NCBI

67 

Jürgensen HJ, Madsen DH, Ingvarsen S, Melander MC, Gårdsvoll H, Patthy L, Engelholm LH and Behrendt N: A novel functional role of collagen glycosylation: Interraction with the endocytic collagen receptor uPARAP/ENDO180. J Biol Chem. 286:32736–32748. 2011. View Article : Google Scholar : PubMed/NCBI

68 

Kogianni G, Walker MM, Waxman J and Sturge J: Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. Eur J Cancer. 45:685–693. 2009. View Article : Google Scholar : PubMed/NCBI

69 

Sulek J, Wagenaar-Miller RA, Shireman J, Molinolo A, Madsen DH, Engelholm LH, Behrendt N and Bugge TH: Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer. J Histochem Cytochem. 55:347–353. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Wienke D, Davies GC, Johnson DA, Sturge J, Lambros MB, Savage K, Elsheikh SE, Green AR, Ellis IO, Robertson D, et al: The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer Res. 67:10230–10240. 2007. View Article : Google Scholar : PubMed/NCBI

71 

Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, Jones C and Isacke CM: A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion. PLoS One. 5:e98082010. View Article : Google Scholar : PubMed/NCBI

72 

Engelholm LH, Ingvarsen S, Jürgensen HJ, Hillig T, Madsen DH, Nielsen BS and Behrendt N: The collagen receptor uPARAP/Endo180. Front Biosci (Landmark Ed). 14:2103–2114. 2009. View Article : Google Scholar : PubMed/NCBI

73 

Curino AC, Engelholm LH, Yamada SS, Holmbeck K, Lund LR, Molinolo AA, Behrendt N, Nielsen BS and Bugge TH: Intracelluar collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy. J Cell Biol. 169:977–985. 2005. View Article : Google Scholar : PubMed/NCBI

74 

Palmieri C, Caley MP, Purshouse K, Fonseca AV, Rodriguez-Teja M, Kogianni G, Woodley L, Odendaal J, Elliott K, Waxman J and Sturge J: Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer. Br J Cancer. 108:163–169. 2013. View Article : Google Scholar : PubMed/NCBI

75 

Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K and Toda M: Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells. J Neurooncol. 103:267–276. 2011. View Article : Google Scholar : PubMed/NCBI

76 

George JN: Platelets. Lancet. 355:1531–1539. 2000. View Article : Google Scholar : PubMed/NCBI

77 

Takagi S, Sato S, Oh-hara T, Takami M, Koike S, Mishima Y, Hatake K and Fujita N: Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2. PLoS One. 8:e736092013. View Article : Google Scholar : PubMed/NCBI

78 

Lowe KL, Finney BA, Deppermann C, Hägerling R, Gazit SL, Frampton J, Buckley C, Camerer E, Nieswandt B, Kiefer F and Watson SP: Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. Blood. 125:3769–3777. 2015. View Article : Google Scholar : PubMed/NCBI

79 

Lowe KL, Navarro-Nunez L and Watson SP: Platelet CLEC-2 and podoplanin in cancer metastasis. Thromb Res. 129:(Suppl 1). S30–S37. 2012. View Article : Google Scholar : PubMed/NCBI

80 

Martín-Villar E, Scholl FG, Gamallo C, Yurrita MM, Muñoz-Guerra M, Cruces J and Quintanilla M: Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer. 113:899–910. 2005. View Article : Google Scholar : PubMed/NCBI

81 

Rodrigo JP, Garcia-Carracedo D, González MV, Mancebo G, Fresno MF and García-Pedrero J: Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas. Mol Cancer. 9:482010. View Article : Google Scholar : PubMed/NCBI

82 

Kato Y, Kaneko M, Sata M, Fujita N, Tsuruo T and Osawa M: Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma. Tumour Biol. 26:195–200. 2005. View Article : Google Scholar : PubMed/NCBI

83 

Kimura N and Kimura I: Podoplanin as a marker for mesothelioma. Pathol Int. 55:83–86. 2005. View Article : Google Scholar : PubMed/NCBI

84 

Kato Y, Fujita N, Kunita A, Sato S, Kaneko M, Osawa M and Tsuruo T: Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J Biol Chem. 278:51599–51605. 2003. View Article : Google Scholar : PubMed/NCBI

85 

Mishima K, Kato Y, Kaneko MK, Nishikawa R, Hirose T and Matsutani M: Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. Acta Neuropathol. 111:483–488. 2006. View Article : Google Scholar : PubMed/NCBI

86 

Liang M, Zhang P and Fu J: Up-regulation of LOX-1 expression by TNF-alpha promotes trans-endothelial migration of MDA-MB-231 breast cancer cells. Cancer Letters. 258:31–37. 2007. View Article : Google Scholar : PubMed/NCBI

87 

Zhang F, Ren S and Zuo Y: DC-SIGN, DC-SIGNR and LSECtin: C-Type Lectins for Infection. Int Rev Immunol. 33:54–66. 2014. View Article : Google Scholar : PubMed/NCBI

88 

Nonaka M, Ma BY, Murai R, Nakamura N, Baba M, Kawasaki N, Hodohara K, Asano S and Kawasaki T: Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells. J Immunol. 180:3347–3356. 2008. View Article : Google Scholar : PubMed/NCBI

89 

Xu F, Liu J, Liu D, Liu B, Wang M, Hu Z, Du X, Tang L and He F: LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses. Cancer Res. 74:3418–3428. 2014. View Article : Google Scholar : PubMed/NCBI

90 

Zhang Z, Chen K, Yan L, Yang Z, Zhu Z, Chen C, Zeng J, Wei W, Qi X, Ren S and Zuo Y: Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in non-Hodgkin lymphoma and significant correlations with lactic acid dehydrogenase and β2-microglobulin. Biochem Cell Biol. 91:214–220. 2013. View Article : Google Scholar : PubMed/NCBI

91 

Keler T, Ramakrishna V and Fanger MW: Mannose receptor-targeted vaccines. Expert Opin Biol Ther. 4:1953–1962. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ding D, Yao Y, Zhang S, Su C and Zhang Y: C‑type lectins facilitate tumor metastasis (Review). Oncol Lett 13: 13-21, 2017.
APA
Ding, D., Yao, Y., Zhang, S., Su, C., & Zhang, Y. (2017). C‑type lectins facilitate tumor metastasis (Review). Oncology Letters, 13, 13-21. https://doi.org/10.3892/ol.2016.5431
MLA
Ding, D., Yao, Y., Zhang, S., Su, C., Zhang, Y."C‑type lectins facilitate tumor metastasis (Review)". Oncology Letters 13.1 (2017): 13-21.
Chicago
Ding, D., Yao, Y., Zhang, S., Su, C., Zhang, Y."C‑type lectins facilitate tumor metastasis (Review)". Oncology Letters 13, no. 1 (2017): 13-21. https://doi.org/10.3892/ol.2016.5431
Copy and paste a formatted citation
x
Spandidos Publications style
Ding D, Yao Y, Zhang S, Su C and Zhang Y: C‑type lectins facilitate tumor metastasis (Review). Oncol Lett 13: 13-21, 2017.
APA
Ding, D., Yao, Y., Zhang, S., Su, C., & Zhang, Y. (2017). C‑type lectins facilitate tumor metastasis (Review). Oncology Letters, 13, 13-21. https://doi.org/10.3892/ol.2016.5431
MLA
Ding, D., Yao, Y., Zhang, S., Su, C., Zhang, Y."C‑type lectins facilitate tumor metastasis (Review)". Oncology Letters 13.1 (2017): 13-21.
Chicago
Ding, D., Yao, Y., Zhang, S., Su, C., Zhang, Y."C‑type lectins facilitate tumor metastasis (Review)". Oncology Letters 13, no. 1 (2017): 13-21. https://doi.org/10.3892/ol.2016.5431
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team