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Article

Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity

  • Authors:
    • Qiusha Tang
    • Mudan Lu
    • Huan Zhou
    • Daozhen Chen
    • Lu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Pathophysiology, Medical College, Southeast University, Nanjing, Jiangsu 210096, P.R. China, Genetic Laboratory, Wuxi Hospital for Maternal and Child Health Care, The Affiliated Hospital of Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China
  • Pages: 384-388
    |
    Published online on: November 24, 2016
       https://doi.org/10.3892/ol.2016.5433
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Abstract

Ovarian cancer patients often have poor prognosis, therefore, it is important to search for more effective therapeutic strategies to treat them. Gambogic acid (GA) exhibits an anti‑tumor effect through various mechanisms, and has multiple targets in tumor cells. The present study aimed to elucidate the efficacy of GA in the treatment of ovarian cancer both in vivo and in vitro by analyzing its impact on cell survival and tumor growth through cell cycle and apoptosis analysis. GA inhibited the growth of ovarian cancer cells in a dose and time dependent manner, and arrested the cell cycle in ovarian cancer cells. Furthermore, GA increased caspase‑3 and caspase‑9 activity and inhibited RELA/NF‑κB p65 (p65) DNA binding activity. Finally, GA suppressed tumor growth in vivo. Therefore, the current study suggests that GA inhibits the growth of ovarian cancer by regulating p65 activity, and may be developed as a novel therapeutic strategy to treat ovarian cancer.
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1 

Perets R, Wyant GA, Muto KW, Bijron JG, Poole BB, Chin KT, Chen JY, Ohman AW, Stepule CD, Kwak S, et al: Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca; Tp53; Pten models. Cancer Cell. 24:751–765. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Jianrong He, Xi Gao and Zefang Ren: The distributed characteristic of female breast and ovarian cancer in the global. Chinese Cancer. 18:169–172. 2009.(In Chinese).

3 

Yang D, Sun Y, Hu L, Zheng H, Ji P, Pecot CV, Zhao Y, Reynolds S, Cheng H, Rupaimoole R, et al: Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell. 23:186–199. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Wang N, Li WW, Li JP, Liu JY, Zhou YC, Zhang Y, Hu J, Huang YH, Chen Y, Wei LC and Shi M: Comparison of concurrent chemoradiotherapy followed by radical surgery and high-dose-rate intracavitary brachytherapy: A retrospective study of 240 patients with FIGO stage IIB cervical carcinoma. Onco Targets Ther. 7:91–100. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Tianmin X, Weiqin C, Shuying W, Yang L and Manhua C: Protection of ovarian function during chemotherapy for ovarian cancer. Eur J Gynaecol Oncol. 35:562–565. 2014.

6 

Wang J and Yuan Z: Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis. Cell Biochem Biophys. 67:199–206. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wang F, Zhang W, Guo L, Bao W, Jin N, Liu R, Liu P, Wang Y, Guo Q and Chen B: Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target protein of rapamycin pathway in multiple myeloma cells. Cancer Sci. 105:1063–1070. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Wen J, Pei H, Wang X, Xie C, Li S, Huang L, Qiu N, Wang W, Cheng X and Chen L: Gambogic acid exhibits anti-psoriatic efficacy through inhibition of angiogenesis and inflammation. J Dermatol Sci. 74:242–250. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wang Y, Xiang W, Wang M, Huang T, Xiao X, Wang L, Tao D, Dong L, Zeng F and Jiang G: Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101. Br J Pharmacol. 171:618–635. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Shi X, Chen X, Li X, Lan X, Zhao C, Liu S, Huang H, Liu N, Liao S, Song W, et al: Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation. Clin Cancer Res. 20:151–163. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Yu Y, Wan Y and Huang C: The biological functions of NF-kappaB1 (p50) and its potential as an anti-cancer target. Curr Cancer Drug Targets. 9:566–571. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Bock FJ, Peintner L, Tanzer M, Manzl C and Villunger A: P53-induced protein with a death domain (PIDD): Master of puppets? Oncogene. 31:4733–4739. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Fei M, Lu M, Wang Y, Zhao Y, He S, Gao S, Ke Q, Liu Y, Li P, Cui X, et al: Arsenic trioxide-induced growth arrest of human hepatocellular carcinoma cells involving FOXO3a expression and localization. Med Oncol. 26:178–185. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Lu M, Fei M, Cheng C, Wang Y, He S, Zhao Y, Gao S, Ke Q, Li P, Cui X and Shen A: Mutant p27 (Kip1) and its potential effect as hepatocellular gene therapy. Arch Med Res. 39:573–581. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Lu M, Ma J, Xue W, Cheng C, Wang Y, Zhao Y, Ke Q, Liu H, Liu Y, Li P, et al: The expression and prognosis of FOXO3a and Skp2 in human hepatocellular carcinoma. Pathol Oncol Res. 15:679–687. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Gui J, Yue Y, Chen R, Xu W and Xiong S: A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-κB signaling. PLoS One. 7:e465152012. View Article : Google Scholar : PubMed/NCBI

17 

Wang Y, Wang Y, Xiang J, Ji F, Deng Y, Tang C, Yang S, Xi Q, Liu R and Di W: Knockdown of CRM1 inhibits the nuclear export of p27 (Kip1) phosphorylated at serine 10 and plays a role in the pathogenesis of epithelial ovarian cancer. Cancer Lett. 343:6–13. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Lu M, Zhao Y, Xu F, Wang Y, Xiang J and Chen D: The expression and prognosis of FOXO3a and Skp2 in human ovarian cancer. Med Oncol. 29:3409–3415. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Lu M, Xiang J, Xu F, Wang Y, Yin Y and Chen D: The expression and significance of pThr32-FOXO3a in human ovarian cancer. Med Oncol. 29:1258–1264. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zhao W, You CC, Zhuang JP, Zu JN, Chi ZY, Xu GP and Yan JL: Viability inhibition effect of gambogic acid combined with cisplatin on osteosarcoma cells via mitochondria-independent apoptotic pathway. Mol Cell Biochem. 382:243–252. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Lu N, Hui H, Yang H, Zhao K, Chen Y, You QD and Guo QL: Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1α pathway. Eur J Pharm Sci. 49:220–226. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Ng AJ, Walia MK, Smeets MF, Mutsaers AJ, Sims NA, Purton LE, Walsh NC, Martin TJ and Walkley CR: The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation. PLoS Genet. 11:e10051602015. View Article : Google Scholar : PubMed/NCBI

23 

Mumblat Y, Kessler O, Ilan N and Neufeld G: Full length semaphorin-3C is an inhibitor of tumor lymphangiogenesis and metastasis. Cancer Res. 75:2177–2186. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Wang Q, Liu Z, Ren J, Morgan S, Assa C and Liu B: Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation. Circ Res. 116:600–611. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Qu Y, Zhang X and Wu R: Knockdown of NF-κB p65 subunit expression suppresses growth of nude mouse lung tumor cell xenografts by activation of Bax apoptotic pathway. Neoplasma. 62:34–40. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang Q, Lu M, Zhou H, Chen D and Liu L: Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity. Oncol Lett 13: 384-388, 2017.
APA
Tang, Q., Lu, M., Zhou, H., Chen, D., & Liu, L. (2017). Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity. Oncology Letters, 13, 384-388. https://doi.org/10.3892/ol.2016.5433
MLA
Tang, Q., Lu, M., Zhou, H., Chen, D., Liu, L."Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity". Oncology Letters 13.1 (2017): 384-388.
Chicago
Tang, Q., Lu, M., Zhou, H., Chen, D., Liu, L."Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity". Oncology Letters 13, no. 1 (2017): 384-388. https://doi.org/10.3892/ol.2016.5433
Copy and paste a formatted citation
x
Spandidos Publications style
Tang Q, Lu M, Zhou H, Chen D and Liu L: Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity. Oncol Lett 13: 384-388, 2017.
APA
Tang, Q., Lu, M., Zhou, H., Chen, D., & Liu, L. (2017). Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity. Oncology Letters, 13, 384-388. https://doi.org/10.3892/ol.2016.5433
MLA
Tang, Q., Lu, M., Zhou, H., Chen, D., Liu, L."Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity". Oncology Letters 13.1 (2017): 384-388.
Chicago
Tang, Q., Lu, M., Zhou, H., Chen, D., Liu, L."Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity". Oncology Letters 13, no. 1 (2017): 384-388. https://doi.org/10.3892/ol.2016.5433
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