Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity

  • Authors:
    • Qiusha Tang
    • Mudan Lu
    • Huan Zhou
    • Daozhen Chen
    • Lu Liu
  • View Affiliations

  • Published online on: November 24, 2016     https://doi.org/10.3892/ol.2016.5433
  • Pages: 384-388
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Abstract

Ovarian cancer patients often have poor prognosis, therefore, it is important to search for more effective therapeutic strategies to treat them. Gambogic acid (GA) exhibits an anti‑tumor effect through various mechanisms, and has multiple targets in tumor cells. The present study aimed to elucidate the efficacy of GA in the treatment of ovarian cancer both in vivo and in vitro by analyzing its impact on cell survival and tumor growth through cell cycle and apoptosis analysis. GA inhibited the growth of ovarian cancer cells in a dose and time dependent manner, and arrested the cell cycle in ovarian cancer cells. Furthermore, GA increased caspase‑3 and caspase‑9 activity and inhibited RELA/NF‑κB p65 (p65) DNA binding activity. Finally, GA suppressed tumor growth in vivo. Therefore, the current study suggests that GA inhibits the growth of ovarian cancer by regulating p65 activity, and may be developed as a novel therapeutic strategy to treat ovarian cancer.
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January-2017
Volume 13 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Tang Q, Lu M, Zhou H, Chen D and Liu L: Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity. Oncol Lett 13: 384-388, 2017
APA
Tang, Q., Lu, M., Zhou, H., Chen, D., & Liu, L. (2017). Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity. Oncology Letters, 13, 384-388. https://doi.org/10.3892/ol.2016.5433
MLA
Tang, Q., Lu, M., Zhou, H., Chen, D., Liu, L."Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity". Oncology Letters 13.1 (2017): 384-388.
Chicago
Tang, Q., Lu, M., Zhou, H., Chen, D., Liu, L."Gambogic acid inhibits the growth of ovarian cancer tumors by regulating p65 activity". Oncology Letters 13, no. 1 (2017): 384-388. https://doi.org/10.3892/ol.2016.5433