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Article

Comparative clinicopathological characteristics of colon and rectal T1 carcinoma

  • Authors:
    • Katsuro Ichimasa
    • Shin‑Ei Kudo
    • Hideyuki Miyachi
    • Yuta Kouyama
    • Takemasa Hayashi
    • Kunihiko Wakamura
    • Tomokazu Hisayuki
    • Toyoki Kudo
    • Masashi Misawa
    • Yuichi Mori
    • Shingo Matsudaira
    • Eiji Hidaka
    • Shigeharu Hamatani
    • Fumio Ishida
  • View Affiliations / Copyright

    Affiliations: Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224‑8503, Japan
  • Pages: 805-810
    |
    Published online on: December 6, 2016
       https://doi.org/10.3892/ol.2016.5464
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Abstract

Lymph node metastasis significantly influences the management of patients with colorectal carcinoma. It has been observed that the biology of colorectal carcinoma differs by location. The aim of the current study was to retrospectively compare the clinicopathological characteristics of patients with colon and rectal T1 carcinomas, particularly their rates of lymph node metastasis. Of the 19,864 patients who underwent endoscopic or surgical resection of colorectal neoplasms at Showa University Northern Yokohama Hospital, 557 had T1 surgically resected carcinomas, including 457 patients with colon T1 carcinomas and 100 patients with rectal T1 carcinomas. Analysed clinicopathological features included patient age, gender, tumor size, morphology, tumor budding, invasion depth, vascular invasion, histological grade, lymphatic invasion and lymph node metastasis. Rectal T1 carcinomas were significantly larger than colon T1 carcinomas (mean ± standard deviation: 23.7±13.1 mm vs. 19.9±11.0 mm, P<0.01) and were accompanied by significantly higher rates of vascular invasion (48.0% vs. 30.2%, P<0.01). Significant differences were not observed among any other clinicopathological factors. In conclusion, tumor location itself was not a risk factor for lymph node metastasis in colorectal T1 carcinomas, even though on average, rectal T1 carcinomas were larger and accompanied by a significantly higher rate of vascular invasion than colon T1 carcinomas.
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1 

Matsuda T, Marugame T, Kamo K, Katanoda K, Ajiki W and Sobue T: Japan Cancer Surveillance Research Group: Cancer incidence and incidence rates in Japan in 2002: Based on data from 11 population-based cancer registries. Jpn J Clin Oncol. 38:641–648. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, Hamaguchi T, Hyodo I, Igarashi M, Ishida H, et al: Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer. Int J Clin Oncol. 20:207–239. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Frattini M, Balestra D, Suardi S, Oggionni M, Alberici P, Radice P, Costa A, Daidone MG, Leo E, Pilotti S, et al: Different genetic features associated with colon and rectal carcinogenesis. Clin Cancer Res. 10:4015–4021. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Wang H, Wei XZ, Fu CG, Zhao RH and Cao FA: Patterns of lymph node metastasis are different in colon and rectal carcinomas. World J Gastroenterol. 16:5375–5379. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Ikematsu H, Yoda Y, Matsuda T, Yamaguchi Y, Hotta K, Kobayashi N, Fujii T, Oono Y, Sakamoto T, Nakajima T, et al: Long-term outcomes after resection for submucosal invasive colorectal cancers. Gastroenterology. 144:551–559; quiz e14. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Pommergaard HC, Gessler B, Burcharth J, Angenete E, Haglind E and Rosenberg J: Preoperative risk factors for anastomotic leakage after resection for colorectal cancer: A systematic review and meta-analysis. Colorectal Dis. 16:662–671. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Kakodkar R, Gupta S and Nundy S: Low anterior resection with total mesorectal excision for rectal cancer: Functional assessment and factors affecting outcome. Colorectal Dis. 8:650–656. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Kobayashi H, Mochizuki H, Morita T, Kotake K, Teramoto T, Kameoka S, Saito Y, Takahashi K, Hase K, Oya M, et al: Characteristics of recurrence after curative resection for T1 colorectal cancer: Japanese multicenter study. J Gastroenterol. 46:203–211. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Bosch SL, Teerenstra S, de Wilt JH, Cunningham C and Nagtegaal ID: Predicting lymph node metastasis in pT1 colorectal cancer: A systematic review of risk factors providing rationale for therapy decisions. Endoscopy. 45:827–834. 2013. View Article : Google Scholar : PubMed/NCBI

10 

The Paris endoscopic classification of superficial neoplastic lesions, . Esophagus, stomach and colon: November 30 to December 1, 2002. Gastrointest Endosc. 58:(Suppl 6). S3–S43. 2003.PubMed/NCBI

11 

Kudo S, Lambert R, Allen JI, Fujii H, Fujii T, Kashida H, Matsuda T, Mori M, Saito H, Shimoda T, et al: Nonpolypoid neoplastic lesions of the colorectal mucosa. Gastrointest Endosc. 68:(Suppl 4). S3–S47. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Kudo S, Tamura S, Nakajima T, Yamano H, Kusaka H and Watanabe H: Diagnosis of colorectal tumorous lesions by magnifying endoscopy. Gastrointest Endosc. 44:8–14. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Matsuda T, Fujii T, Saito Y, Nakajima T, Uraoka T, Kobayashi N, Ikehara H, Ikematsu H, Fu KI, Emura F, et al: Efficacy of the invasive/non-invasive pattern by magnifying chromoendoscopy to estimate the depth of invasion of early colorectal neoplasms. Am J Gastroenterol. 103:2700–2706. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Kudo S, Tamegai Y, Yamano H, Imai Y, Kogure E and Kashida H: Endoscopic mucosal resection of the colon: The Japanese technique. Gastrointest Endosc Clin N Am. 11:519–535. 2001.PubMed/NCBI

15 

Tsuruta O, Toyonaga A, Ikeda H, Tanikawa K and Morimatsu M: Clinicopathological study of superficial-type invasive carcinoma of the colorectum. Int J Oncol. 10:1003–1008. 1997.PubMed/NCBI

16 

Bosman FT, Carneiro F, Hruban RH and Theise ND: WHO Classification of Tumours of the Digestive System Lyon. France: 2010

17 

Ueno H, Mochizuki H, Hashiguchi Y, Shimazaki H, Aida S, Hase K, Matsukuma S, Kanai T, Kurihara H, Ozawa K, et al: Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology. 127:385–394. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Zenni GC, Abraham K, Harford FJ, Potocki DM, Herman C and Dobrin PB: Characteristics of rectal carcinomas that predict the presence of lymph node metastases: Implications for patient selection for local therapy. J Surg Oncol. 67:99–103. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Saclarides TJ, Bhattacharyya AK, BrittonKuzel C, Szeluga D and Economou SG: Predicting lymph node metastases in rectal cancer. Dis Colon Rectum. 37:52–57. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Chok KS and Law WL: Prognostic factors affecting survival and recurrence of patients with pT1 and pT2 colorectal cancer. World J Surg. 31:1485–1490. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Paty PB, Enker WE, Cohen AM and Lauwers GY: Treatment of rectal cancer by low anterior resection with coloanal anastomosis. Ann Surg. 219:365–373. 1994. View Article : Google Scholar : PubMed/NCBI

22 

Kudo S: Endoscopic mucosal resection of flat and depressed types of early colorectal cancer. Endoscopy. 25:455–461. 1993. View Article : Google Scholar : PubMed/NCBI

23 

Uraoka T, Saito Y, Matsuda T, Ikehara H, Gotoda T, Saito D and Fujii T: Endoscopic indications for endoscopic mucosal resection of laterally spreading tumours in the colorectum. Gut. 55:1592–1597. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Terasaki M, Tanaka S, Shigita K, Asayama N, Nishiyama S, Hayashi N, Nakadoi K, Oka S and Chayama K: Risk factors for delayed bleeding after endoscopic submucosal dissection for colorectal neoplasms. Int J Colorectal Dis. 29:877–882. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Labianca R, Nordlinger B, Beretta GD, Mosconi S, Mandalà M, Cervantes A and Arnold D: ESMO Guidelines Working Group: Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24:(Suppl 6). vi64–vi72. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Benson AB III, BekaiiSaab T, Chan E, Chen YJ, Choti MA, Cooper HS, Engstrom PF, Enzinger PC, Fakih MG, Fenton MJ, et al: Localized colon cancer, version 3.2013: Featured updates to the NCCN Guidelines. J Natl Compr Canc Netw. 11:519–528. 2013.PubMed/NCBI

27 

Brown CE and Warren S: Visceral metastasis from rectal carcinoma. Surg Gynecol Obstet. 66:611–621. 1938.

28 

Messenger DE, Driman DK and Kirsch R: Developments in the assessment of venous invasion in colorectal cancer: Implications for future practice and patient outcome. Hum Pathol. 43:965–973. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Kikuchi R, Takano M, Takagi K, Fujimoto N, Nozaki R, Fujiyoshi T and Uchida Y: Management of early invasive colorectal cancer. Risk of recurrence and clinical guidelines. Dis Colon Rectum. 38:1286–1295. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Okuyama T, Oya M and Ishikawa H: Budding as a risk factor for lymph node metastasis in pT1 or pT2 well-differentiated colorectal adenocarcinoma. Dis Colon Rectum. 45:628–634. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Nascimbeni R, Burgart LJ, Nivatvongs S and Larson DR: Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum. 45:200–206. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Sakuragi M, Togashi K, Konishi F, Koinuma K, Kawamura Y, Okada M and Nagai H: Predictive factors for lymph node metastasis in T1 stage colorectal carcinomas. Dis Colon Rectum. 46:1626–1632. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ichimasa K, Kudo SE, Miyachi H, Kouyama Y, Hayashi T, Wakamura K, Hisayuki T, Kudo T, Misawa M, Mori Y, Mori Y, et al: Comparative clinicopathological characteristics of colon and rectal T1 carcinoma. Oncol Lett 13: 805-810, 2017.
APA
Ichimasa, K., Kudo, S., Miyachi, H., Kouyama, Y., Hayashi, T., Wakamura, K. ... Ishida, F. (2017). Comparative clinicopathological characteristics of colon and rectal T1 carcinoma. Oncology Letters, 13, 805-810. https://doi.org/10.3892/ol.2016.5464
MLA
Ichimasa, K., Kudo, S., Miyachi, H., Kouyama, Y., Hayashi, T., Wakamura, K., Hisayuki, T., Kudo, T., Misawa, M., Mori, Y., Matsudaira, S., Hidaka, E., Hamatani, S., Ishida, F."Comparative clinicopathological characteristics of colon and rectal T1 carcinoma". Oncology Letters 13.2 (2017): 805-810.
Chicago
Ichimasa, K., Kudo, S., Miyachi, H., Kouyama, Y., Hayashi, T., Wakamura, K., Hisayuki, T., Kudo, T., Misawa, M., Mori, Y., Matsudaira, S., Hidaka, E., Hamatani, S., Ishida, F."Comparative clinicopathological characteristics of colon and rectal T1 carcinoma". Oncology Letters 13, no. 2 (2017): 805-810. https://doi.org/10.3892/ol.2016.5464
Copy and paste a formatted citation
x
Spandidos Publications style
Ichimasa K, Kudo SE, Miyachi H, Kouyama Y, Hayashi T, Wakamura K, Hisayuki T, Kudo T, Misawa M, Mori Y, Mori Y, et al: Comparative clinicopathological characteristics of colon and rectal T1 carcinoma. Oncol Lett 13: 805-810, 2017.
APA
Ichimasa, K., Kudo, S., Miyachi, H., Kouyama, Y., Hayashi, T., Wakamura, K. ... Ishida, F. (2017). Comparative clinicopathological characteristics of colon and rectal T1 carcinoma. Oncology Letters, 13, 805-810. https://doi.org/10.3892/ol.2016.5464
MLA
Ichimasa, K., Kudo, S., Miyachi, H., Kouyama, Y., Hayashi, T., Wakamura, K., Hisayuki, T., Kudo, T., Misawa, M., Mori, Y., Matsudaira, S., Hidaka, E., Hamatani, S., Ishida, F."Comparative clinicopathological characteristics of colon and rectal T1 carcinoma". Oncology Letters 13.2 (2017): 805-810.
Chicago
Ichimasa, K., Kudo, S., Miyachi, H., Kouyama, Y., Hayashi, T., Wakamura, K., Hisayuki, T., Kudo, T., Misawa, M., Mori, Y., Matsudaira, S., Hidaka, E., Hamatani, S., Ishida, F."Comparative clinicopathological characteristics of colon and rectal T1 carcinoma". Oncology Letters 13, no. 2 (2017): 805-810. https://doi.org/10.3892/ol.2016.5464
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