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Review Open Access

IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review)

  • Authors:
    • Alessandro Morotti
    • Sabrina Crivellaro
    • Cristina Panuzzo
    • Giovanna Carrà
    • Angelo Guerrasio
    • Giuseppe Saglio
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Biological Sciences, University of Turin, I‑10043 Orbassano, Turin, Italy
    Copyright: © Morotti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 531-534
    |
    Published online on: December 6, 2016
       https://doi.org/10.3892/ol.2016.5465
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Abstract

Nuclear factor κB (NF‑κB) is an essential component of tumorigenesis and resistance to cancer treatments. NFKB inhibitor α (IκB‑α) acts as a negative regulator of the classical NF‑κB pathway through its ability to maintain the presence of NF‑κB in the cytoplasm. However, IκB‑α is also able to form a complex with tumor protein p53, promoting its inactivation. Recently, we demonstrated that IκB‑α is able to mediate p53 nuclear exclusion and inactivation in chronic myeloid leukemia, indicating that IκB‑α can modulate either oncogenic or tumor‑suppressive functions, with important implications for cancer treatment. The present review describes the role of IκB‑α in cancer pathogenesis, with particular attention to hematological cancers, and highlights the involvement of IκB‑α in the regulation of p53 tumor‑suppressive functions.
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Copy and paste a formatted citation
Spandidos Publications style
Morotti A, Crivellaro S, Panuzzo C, Carrà G, Guerrasio A and Saglio G: IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review). Oncol Lett 13: 531-534, 2017.
APA
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., & Saglio, G. (2017). IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review). Oncology Letters, 13, 531-534. https://doi.org/10.3892/ol.2016.5465
MLA
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., Saglio, G."IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review)". Oncology Letters 13.2 (2017): 531-534.
Chicago
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., Saglio, G."IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review)". Oncology Letters 13, no. 2 (2017): 531-534. https://doi.org/10.3892/ol.2016.5465
Copy and paste a formatted citation
x
Spandidos Publications style
Morotti A, Crivellaro S, Panuzzo C, Carrà G, Guerrasio A and Saglio G: IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review). Oncol Lett 13: 531-534, 2017.
APA
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., & Saglio, G. (2017). IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review). Oncology Letters, 13, 531-534. https://doi.org/10.3892/ol.2016.5465
MLA
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., Saglio, G."IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review)". Oncology Letters 13.2 (2017): 531-534.
Chicago
Morotti, A., Crivellaro, S., Panuzzo, C., Carrà, G., Guerrasio, A., Saglio, G."IκB‑α: At the crossroad between oncogenic and tumor‑suppressive signals (Review)". Oncology Letters 13, no. 2 (2017): 531-534. https://doi.org/10.3892/ol.2016.5465
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