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Article Open Access

Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells

  • Authors:
    • Zejian Huang
    • Ning Zhang
    • Wenda Li
    • Jun Cao
    • Lei Zhang
    • Yajin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, Sun Yat‑Sen Memorial Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. China, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 715-721
    |
    Published online on: December 6, 2016
       https://doi.org/10.3892/ol.2016.5466
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Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer‑associated death. Due to rapid progression and metastasis, the long‑term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chondrolectin (CHODL) is commonly overexpressed in the majority of lung cancers, indicating a possible correlation between CHODL and metastasis of lung cancer cells. Our investigation shows that the expression of CHODL is significantly decreased in HCC clinical samples and in HCC cell lines. Overexpression of CHODL in SMMC7721 cells with a lentiviral vector increased SMMC7721 cell migration and invasion. Our findings establish for the first time an association between human CHODL and HCC metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Zhang N, Li W, Cao J, Zhang L and Chen Y: Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells. Oncol Lett 13: 715-721, 2017.
APA
Huang, Z., Zhang, N., Li, W., Cao, J., Zhang, L., & Chen, Y. (2017). Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells. Oncology Letters, 13, 715-721. https://doi.org/10.3892/ol.2016.5466
MLA
Huang, Z., Zhang, N., Li, W., Cao, J., Zhang, L., Chen, Y."Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells". Oncology Letters 13.2 (2017): 715-721.
Chicago
Huang, Z., Zhang, N., Li, W., Cao, J., Zhang, L., Chen, Y."Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells". Oncology Letters 13, no. 2 (2017): 715-721. https://doi.org/10.3892/ol.2016.5466
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Z, Zhang N, Li W, Cao J, Zhang L and Chen Y: Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells. Oncol Lett 13: 715-721, 2017.
APA
Huang, Z., Zhang, N., Li, W., Cao, J., Zhang, L., & Chen, Y. (2017). Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells. Oncology Letters, 13, 715-721. https://doi.org/10.3892/ol.2016.5466
MLA
Huang, Z., Zhang, N., Li, W., Cao, J., Zhang, L., Chen, Y."Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells". Oncology Letters 13.2 (2017): 715-721.
Chicago
Huang, Z., Zhang, N., Li, W., Cao, J., Zhang, L., Chen, Y."Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells". Oncology Letters 13, no. 2 (2017): 715-721. https://doi.org/10.3892/ol.2016.5466
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