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Article

Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells

Retraction in: /10.3892/ol.2023.14173
  • Authors:
    • Aisha Maimaitili
    • Zunhua Shu
    • Xiaojiang Cheng
    • Kadeer Kaheerman
    • Alifu Sikandeer
    • Weimin Li
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang Uyghur Autonomous Region 830054, P.R. China, Department of Medical Affairs, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin 130021, P.R. China
  • Pages: 1007-1013
    |
    Published online on: December 8, 2016
       https://doi.org/10.3892/ol.2016.5474
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Abstract

The aim of the current study was to investigate the anticancer potential of arctigenin, a natural lignan compound, in malignant gliomas. The U87MG and T98G human glioma cell lines were treated with various concentrations of arctigenin for 48 h and the effects of arctigenin on the aggressive phenotypes of glioma cells were assessed. The results demonstrated that arctigenin dose‑dependently inhibited the growth of U87MG and T98G cells, as determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and bromodeoxyuridine incorporation assays. Arctigenin exposure also induced a 60‑75% reduction in colony formation compared with vehicle‑treated control cells. However, arctigenin was not observed to affect the invasiveness of glioma cells. Arctigenin significantly increased the proportion of cells in the G0/G1 phase and reduced the number of cells in the S phase, as compared with the control group (P<0.05). Western blot analysis demonstrated that arctigenin increased the expression levels of p21, retinoblastoma and p53 proteins, and significantly decreased the expression levels of cyclin D1 and cyclin‑dependent kinase 4 proteins. Additionally, arctigenin was able to induce apoptosis in glioma cells, coupled with increased expression levels of cleaved caspase-3 and the pro‑apoptotic BCL2‑associated X protein. Furthermore, arctigenin‑induced apoptosis was significantly suppressed by the pretreatment of cells with Z-DEVD‑FMK, a caspase‑3 inhibitor. In conclusion, the results suggest that arctigenin is able to inhibit cell proliferation and may induce apoptosis and cell cycle arrest at the G0/G1 phase in glioma cells. These results warrant further investigation of the anticancer effects of arctigenin in animal models of gliomas.
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Copy and paste a formatted citation
Spandidos Publications style
Maimaitili A, Shu Z, Cheng X, Kaheerman K, Sikandeer A and Li W: Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells Retraction in /10.3892/ol.2023.14173. Oncol Lett 13: 1007-1013, 2017.
APA
Maimaitili, A., Shu, Z., Cheng, X., Kaheerman, K., Sikandeer, A., & Li, W. (2017). Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells Retraction in /10.3892/ol.2023.14173. Oncology Letters, 13, 1007-1013. https://doi.org/10.3892/ol.2016.5474
MLA
Maimaitili, A., Shu, Z., Cheng, X., Kaheerman, K., Sikandeer, A., Li, W."Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells Retraction in /10.3892/ol.2023.14173". Oncology Letters 13.2 (2017): 1007-1013.
Chicago
Maimaitili, A., Shu, Z., Cheng, X., Kaheerman, K., Sikandeer, A., Li, W."Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells Retraction in /10.3892/ol.2023.14173". Oncology Letters 13, no. 2 (2017): 1007-1013. https://doi.org/10.3892/ol.2016.5474
Copy and paste a formatted citation
x
Spandidos Publications style
Maimaitili A, Shu Z, Cheng X, Kaheerman K, Sikandeer A and Li W: Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells Retraction in /10.3892/ol.2023.14173. Oncol Lett 13: 1007-1013, 2017.
APA
Maimaitili, A., Shu, Z., Cheng, X., Kaheerman, K., Sikandeer, A., & Li, W. (2017). Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells Retraction in /10.3892/ol.2023.14173. Oncology Letters, 13, 1007-1013. https://doi.org/10.3892/ol.2016.5474
MLA
Maimaitili, A., Shu, Z., Cheng, X., Kaheerman, K., Sikandeer, A., Li, W."Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells Retraction in /10.3892/ol.2023.14173". Oncology Letters 13.2 (2017): 1007-1013.
Chicago
Maimaitili, A., Shu, Z., Cheng, X., Kaheerman, K., Sikandeer, A., Li, W."Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells Retraction in /10.3892/ol.2023.14173". Oncology Letters 13, no. 2 (2017): 1007-1013. https://doi.org/10.3892/ol.2016.5474
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