Open Access

Bioinformatic identification of candidate genes induced by trichostatin A in BGC-823 gastric cancer cells

  • Authors:
    • Yunlong Li
    • Lisha Zhang
    • Chunfa Yang
    • Riheng Li
    • Longbin Shang
    • Xiaoming Zou
  • View Affiliations

  • Published online on: December 12, 2016     https://doi.org/10.3892/ol.2016.5485
  • Pages: 777-783
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to identify the candidate genes induced by trichostatin A (TSA) in BGC-823 gastric cancer (GC) cells and to explore the possible inhibition mechanism of TSA in GC. Gene expression data were obtained through chip detection, and differentially expressed genes (DEGs) between GC cells treated with TSA and untreated GC cells (control group) were identified. Gene ontology analysis of the DEGs was performed using the database for annotation, visualization and integrated discovery. Then sub‑pathway enrichment analysis was performed and a microRNA (miRNA) regulatory network was constructed. We selected 76 DEGs, among which 43 were downregulated genes and 33 were upregulated genes. By sub‑pathway enrichment analysis of the DEGs, the propanoate metabolism pathway was selected as the sub‑pathway. By constructing a miRNA regulatory network, we identified that DKK1 and KLF13 were the top hub nodes. The propanoate metabolism pathway and the genes DKK1 and KLF13 may play significant roles in the inhibition of GC induced by TSA. These genes may be potential therapeutic targets for GC. However, further experiments are still required to confirm our results.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li Y, Zhang L, Yang C, Li R, Shang L and Zou X: Bioinformatic identification of candidate genes induced by trichostatin A in BGC-823 gastric cancer cells. Oncol Lett 13: 777-783, 2017
APA
Li, Y., Zhang, L., Yang, C., Li, R., Shang, L., & Zou, X. (2017). Bioinformatic identification of candidate genes induced by trichostatin A in BGC-823 gastric cancer cells. Oncology Letters, 13, 777-783. https://doi.org/10.3892/ol.2016.5485
MLA
Li, Y., Zhang, L., Yang, C., Li, R., Shang, L., Zou, X."Bioinformatic identification of candidate genes induced by trichostatin A in BGC-823 gastric cancer cells". Oncology Letters 13.2 (2017): 777-783.
Chicago
Li, Y., Zhang, L., Yang, C., Li, R., Shang, L., Zou, X."Bioinformatic identification of candidate genes induced by trichostatin A in BGC-823 gastric cancer cells". Oncology Letters 13, no. 2 (2017): 777-783. https://doi.org/10.3892/ol.2016.5485