Potential regulation of glioma through the induction of apoptosis signaling via Egl‑9 family hypoxia‑inducible factor 3

  • Authors:
    • Ke Mao
    • Chao You
    • Ding Lei
    • Heng Zhang
  • View Affiliations

  • Published online on: December 14, 2016     https://doi.org/10.3892/ol.2016.5492
  • Pages: 893-897
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Abstract

Glioma is an aggressive form of brain cancer that occurs following the abnormal proliferation of glial cells. Although glioma cannot spread to other organs, the morbidity and mortality rates of the disease are high, even following surgery, radiotherapy and chemotherapy. The function of Egl‑9 family hypoxia‑inducible factor 3 (Egln3) in cancer is controversial, and it is debated as to whether Egln3 positively or negatively regulates tumors. In the present study, a mouse model of low‑grade glioma was successfully established. Through the use of immunohistochemical and western blot analyses, it was demonstrated that Egln3 expression in glioma tissue performed an important role in regulation by amplifying the signals for apoptosis, as determined by an increase in DNA fragments. Furthermore, Egln3 expression was inhibited by the administration of dimethyloxalylglycine, and the downregulated expression of Egln3 had marked effects on the regulation of glioma through apoptosis. The present study therefore provides evidence of an association between Egln3 expression and apoptosis in low‑grade glioma.
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February-2017
Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Mao K, You C, Lei D and Zhang H: Potential regulation of glioma through the induction of apoptosis signaling via Egl‑9 family hypoxia‑inducible factor 3. Oncol Lett 13: 893-897, 2017
APA
Mao, K., You, C., Lei, D., & Zhang, H. (2017). Potential regulation of glioma through the induction of apoptosis signaling via Egl‑9 family hypoxia‑inducible factor 3. Oncology Letters, 13, 893-897. https://doi.org/10.3892/ol.2016.5492
MLA
Mao, K., You, C., Lei, D., Zhang, H."Potential regulation of glioma through the induction of apoptosis signaling via Egl‑9 family hypoxia‑inducible factor 3". Oncology Letters 13.2 (2017): 893-897.
Chicago
Mao, K., You, C., Lei, D., Zhang, H."Potential regulation of glioma through the induction of apoptosis signaling via Egl‑9 family hypoxia‑inducible factor 3". Oncology Letters 13, no. 2 (2017): 893-897. https://doi.org/10.3892/ol.2016.5492