Evaluation of nano‑magnetic fluid on malignant glioma cells

Xu,Hongsheng; Zong,Hailiang; Ma,Chong; Ming,Xing; Shang,Ming; Li,Kai; He,Xiaoguang; Cao,Lei

doi:10.3892/ol.2016.5513

February-2017 Volume 13 Issue 2

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February-2017 Volume 13 Issue 2

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Article Open Access

Evaluation of nano‑magnetic fluid on malignant glioma cells

Authors:
- Hongsheng Xu
- Hailiang Zong
- Chong Ma
- Xing Ming
- Ming Shang
- Kai Li
- Xiaoguang He
- Lei Cao
View Affiliations / Copyright

Affiliations: Department of Neurosurgery, Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu 221009, P.R. China

Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 677-680
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Published online on: December 19, 2016

https://doi.org/10.3892/ol.2016.5513
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Abstract

The temperature variation rule of nano-magnetic fluid in the specific magnetic field and the effect on the treatment of malignant glioma were examined. The temperature variation of nano‑magnetic fluid in the specific magnetic field was investigated by heating in vitro, and cell morphology was observed through optical microscopy and electron microscopy. MTT detection also was used to detect the effect of Fe3O4 nanometer magnetic fluid hyperthermia (MFH) on the proliferation of human U251 glioma cell line. The Fe3O4 nano MFH experiment was used to detect the inhibition rate of the tumor volume in nude mice with tumors. The results of the experiment showed that the heating ability of magnetic fluid was positively correlated with its concentration at the same intensity of the magnetic field. The results also indicated the prominent inhibitory effect of nanometer MFH on the proliferation of glioma cells, which was a dose‑dependent relationship with nanometer magnetic fluid concentration. The hyperthermia experiment of nude mice with tumors displayed a significant inhibiting effect of Fe3O4 nanometer magnetic fluid in glioma volume. These results explain that iron (II,III) oxide (Fe3O4) nanometer MFH can inhibit the proliferation of U251 glioma cells, and has an obvious inhibitory effect on glioma volume, which plays a certain role in the treatment of brain glioma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Evaluation of nano‑magnetic fluid on malignant glioma cells

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