Familial risk for lung cancer (Review)

  • Authors:
    • Madiha Kanwal
    • Xiao‑Ji Ding
    • Yi Cao
  • View Affiliations

  • Published online on: December 20, 2016     https://doi.org/10.3892/ol.2016.5518
  • Pages: 535-542
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Lung cancer, which has a low survival rate, is a leading cause of cancer-associated mortality worldwide. Smoking and air pollution are the major causes of lung cancer; however, numerous studies have demonstrated that genetic factors also contribute to the development of lung cancer. A family history of lung cancer increases the risk for the disease in both smokers and never‑smokers. This review focuses on familial lung cancer, in particular on the familial aggregation of lung cancer. The development of familial lung cancer involves shared environmental and genetic factors among family members. Familial lung cancer represents a good model for investigating the association between environmental and genetic factors, as well as for identifying susceptibility genes for lung cancer. In addition, studies on familial lung cancer may help to elucidate the etiology and mechanism of lung cancer, and may identify novel biomarkers for early detection and diagnosis, targeted therapy and improved prevention strategies. This review presents the aetiology and molecular biology of lung cancer and then systematically introduces and discusses several aspects of familial lung cancer, including the characteristics of familial lung cancer, population‑based studies on familial lung cancer and the genetics of familial lung cancer.
View References

Related Articles

Journal Cover

Volume 13 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
Spandidos Publications style
Kanwal M, Ding XJ and Cao Y: Familial risk for lung cancer (Review). Oncol Lett 13: 535-542, 2017
Kanwal, M., Ding, X., & Cao, Y. (2017). Familial risk for lung cancer (Review). Oncology Letters, 13, 535-542. https://doi.org/10.3892/ol.2016.5518
Kanwal, M., Ding, X., Cao, Y."Familial risk for lung cancer (Review)". Oncology Letters 13.2 (2017): 535-542.
Kanwal, M., Ding, X., Cao, Y."Familial risk for lung cancer (Review)". Oncology Letters 13, no. 2 (2017): 535-542. https://doi.org/10.3892/ol.2016.5518