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Review

Familial risk for lung cancer (Review)

  • Authors:
    • Madiha Kanwal
    • Xiao‑Ji Ding
    • Yi Cao
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular and Experimental Pathology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China
  • Pages: 535-542
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    Published online on: December 20, 2016
       https://doi.org/10.3892/ol.2016.5518
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Abstract

Lung cancer, which has a low survival rate, is a leading cause of cancer-associated mortality worldwide. Smoking and air pollution are the major causes of lung cancer; however, numerous studies have demonstrated that genetic factors also contribute to the development of lung cancer. A family history of lung cancer increases the risk for the disease in both smokers and never‑smokers. This review focuses on familial lung cancer, in particular on the familial aggregation of lung cancer. The development of familial lung cancer involves shared environmental and genetic factors among family members. Familial lung cancer represents a good model for investigating the association between environmental and genetic factors, as well as for identifying susceptibility genes for lung cancer. In addition, studies on familial lung cancer may help to elucidate the etiology and mechanism of lung cancer, and may identify novel biomarkers for early detection and diagnosis, targeted therapy and improved prevention strategies. This review presents the aetiology and molecular biology of lung cancer and then systematically introduces and discusses several aspects of familial lung cancer, including the characteristics of familial lung cancer, population‑based studies on familial lung cancer and the genetics of familial lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kanwal M, Ding XJ and Cao Y: Familial risk for lung cancer (Review). Oncol Lett 13: 535-542, 2017.
APA
Kanwal, M., Ding, X., & Cao, Y. (2017). Familial risk for lung cancer (Review). Oncology Letters, 13, 535-542. https://doi.org/10.3892/ol.2016.5518
MLA
Kanwal, M., Ding, X., Cao, Y."Familial risk for lung cancer (Review)". Oncology Letters 13.2 (2017): 535-542.
Chicago
Kanwal, M., Ding, X., Cao, Y."Familial risk for lung cancer (Review)". Oncology Letters 13, no. 2 (2017): 535-542. https://doi.org/10.3892/ol.2016.5518
Copy and paste a formatted citation
x
Spandidos Publications style
Kanwal M, Ding XJ and Cao Y: Familial risk for lung cancer (Review). Oncol Lett 13: 535-542, 2017.
APA
Kanwal, M., Ding, X., & Cao, Y. (2017). Familial risk for lung cancer (Review). Oncology Letters, 13, 535-542. https://doi.org/10.3892/ol.2016.5518
MLA
Kanwal, M., Ding, X., Cao, Y."Familial risk for lung cancer (Review)". Oncology Letters 13.2 (2017): 535-542.
Chicago
Kanwal, M., Ding, X., Cao, Y."Familial risk for lung cancer (Review)". Oncology Letters 13, no. 2 (2017): 535-542. https://doi.org/10.3892/ol.2016.5518
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