Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2017 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2017 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism

  • Authors:
    • Jianchang Li
    • Mingning Qiu
    • Lieqian Chen
    • Lei Liu
    • Guobin Tan
    • Jianjun Liu
  • View Affiliations / Copyright

    Affiliations: Laboratory of Urology, Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 613-620
    |
    Published online on: December 20, 2016
       https://doi.org/10.3892/ol.2016.5519
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the effect of resveratrol on renal carcinoma cells and explore possible renin‑angiotensin system‑associated mechanisms. Subsequent to resveratrol treatment, the cell viability, apoptosis rate, cytotoxicity levels, caspase 3/7 activity and the levels of angiotensin II (AngII), AngII type 1 receptor (AT1R), vascular endothelial growth factor (VEGF) and cyclooxygenase‑2 (COX‑2) were evaluated in renal carcinoma cells. The effects of AngII, AT1R, VEGF and COX‑2 on resveratrol‑induced cell growth inhibition and apoptosis were also examined. The results indicated that resveratrol treatment may suppress growth, induce apoptosis, and decrease AngII, AT1R, VEGF and COX‑2 levels in renal carcinoma ACHN and A498 cells. In addition, resveratrol‑induced cell growth suppression and apoptosis were reversed when co‑culturing with AT1R or VEGF. Thus, resveratrol may suppress renal carcinoma cell proliferation and induce apoptosis via an AT1R/VEGF pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S and Takada Y: Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies. Anticancer Res. 24:2783–2840. 2004.PubMed/NCBI

2 

Carter LG, D'Orazio JA and Pearson KJ: Resveratrol and cancer: Focus on in vivo evidence. Endocr-Relat Cancer. 21:R209–R225. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Ndiaye M, Kumar R and Ahmad N: Resveratrol in cancer management: Where are we and where we go from here? Ann N Y Acad Sci. 1215:144–149. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Reagan-Shaw S, Mukhtar H and Ahmad N: Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells. Photochem Photobiol. 84:415–421. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Wu ML, Li H, Yu LJ, Chen XY, Kong QY, Song X, Shu XH and Liu J: Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells. PLoS One. 9:e898062014. View Article : Google Scholar : PubMed/NCBI

6 

Nishimura H: Renin-angiotensin system in vertebrates: Phylogenetic view of structure and function. Anat Sci Int. Oct 7–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

7 

Bradshaw AR, Wickremesekera AC, Brasch HD, Chibnall AM, Davis PF, Tan ST and Itinteang T: Glioblastoma multiforme cancer stem cells express components of the renin-angiotensin system. Front Surg. 3:512016. View Article : Google Scholar : PubMed/NCBI

8 

Yoshida T, Kinoshita H, Fukui K, Matsuzaki T, Yoshida K, Mishima T, Yanishi M, Komai Y, Sugi M, Inoue T, et al: Prognostic impact of renin-angiotensin inhibitors in patients with bladder cancer undergoing radical cystectomy. Ann Surg Oncol. Oct 11–2016.(Epub ahead of print). View Article : Google Scholar

9 

Miyajima A, Yazawa S, Kosaka T, Tanaka N, Shirotake S, Mizuno R, Kikuchi E and Oya M: Prognostic impact of renin-angiotensin system blockade on renal cell carcinoma after surgery. Ann Surg Oncol. 22:3751–3759. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Yang R, Zhang H and Zhu L: Inhibitory effect of resveratrol on the expression of the VEGF gene and proliferation in renal cancer cells. Mol Med Rep. 4:981–983. 2011.PubMed/NCBI

11 

Shirotake S, Miyajima A, Kosaka T, Tanaka N, Kikuchi E, Mikami S, Okada Y and Oya M: Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer. Am J Pathol. 180:1008–1016. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Crowley SD and Coffman TM: Recent advances involving the renin-angiotensin system. Exp Cell Res. 318:1049–1056. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Arrieta O, PinedaOlvera B, GuevaraSalazar P, Hernández-Pedro N, Morales-Espinosa D, Cerón-Lizarraga TL, González-De la Rosa CH, Rembao D, Segura-Pacheco B and Sotelo J: Expression of AT1 and AT2 angiotensin receptors in astrocytomas is associated with poor prognosis. Br J Cancer. 99:160–166. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Li SH, Lu HI, Chang AY, Huang WT, Lin WC, Lee CC, Tien WY, Lan YC, Tsai HT and Chen CH: Angiotensin II type I receptor (AT1R) is an independent prognosticator of esophageal squamous cell carcinoma and promotes cells proliferation via mTOR activation. Oncotarget. Aug 24–2016.(Epub ahead of print).

15 

Dolley-Hitze T, Jouan F, Martin B, Mottier S, Edeline J, Moranne O, Le Pogamp P, Belaud-Rotureau MA, Patard JJ, Rioux-Leclercq N and Vigneau C: Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? Br J Cancer. 103:1698–1705. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Passos-Silva DG, VeranoBraga T and Santos RA: Angiotensin-(1–7): Beyond the cardio-renal actions. Clin Sci (Lond). 124:443–456. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Ferrara N and Kerbel RS: Angiogenesis as a therapeutic target. Nature. 438:967–974. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Ferrara N, Gerber HP and LeCouter J: The biology of VEGF and its receptors. Nat Med. 9:669–676. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Cheng YD, Yang H, Chen GQ and Zhang ZC: Molecularly targeted drugs for metastatic colorectal cancer. Drug Des Devel Ther. 7:1315–1322. 2013.PubMed/NCBI

20 

Ding C, Li L, Yang T, Fan X and Wu G: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model. BMC Cancer. 16:7912016. View Article : Google Scholar : PubMed/NCBI

21 

Anandanadesan R, Gong Q, Chipitsyna G, Witkiewicz A, Yeo CJ and Arafat HA: Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling. J Gastrointest Surg. 12:57–66. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Hoellen F, Waldmann A, BanzJansen C, Rody A, Heide M, Köster F, Ribbat-Idel J, Thorns C, Gebhard M, Oberländer M, et al: Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion. Oncol Lett. 12:2351–2356. 2016.PubMed/NCBI

23 

Ali-Fehmi R, Morris RT, Bandyopadhyay S, Che M, Schimp V, Malone JM Jr and Munkarah AR: Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival. Am J Obstet Gynecol. 192:819–825. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Subbaramaiah K and Dannenberg AJ: Cyclooxygenase 2: A molecular target for cancer prevention and treatment. Trends Pharmacol Sci. 24:96–102. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Schmedtje JF Jr, Ji YS, Liu WL, DuBois RN and Runge MS: Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J Biol Chem. 272:601–608. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, et al: Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis. 31:427–434. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Rüegg C, Dormond O and Mariotti A: Endothelial cell integrins and COX-2: Mediators and therapeutic targets of tumor angiogenesis. Biochim Biophys Acta. 1654:51–67. 2004.PubMed/NCBI

28 

Yaseen A, Chen S, Hock S, Rosato R, Dent P, Dai Y and Grant S: Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway. Mol Pharmacol. 82:1030–1041. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Singh N, Nigam M, Ranjan V, Zaidi D, Garg VK, Sharma S, Chaturvedi R, Shankar R, Kumar S, Sharma R, et al: Resveratrol as an adjunct therapy in cyclophosphamide-treated MCF-7 cells and breast tumor explants. Cancer Sci. 102:1059–1067. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Shi Y, Yang S, Troup S, Lu X, Callaghan S, Park DS, Xing Y and Yang X: Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncol Rep. 25:1713–1719. 2011.PubMed/NCBI

31 

Chottanapund S, Van Duursen MB, Navasumrit P, Hunsonti P, Timtavorn S, Ruchirawat M and Van den Berg M: Anti-aromatase effect of resveratrol and melatonin on hormonal positive breast cancer cells co-cultured with breast adipose fibroblasts. Toxicol In Vitro. 28:1215–1221. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Leon-Galicia I, DiazChavez J, GarciaVilla E, UribeFigueroa L, HidalgoMiranda A, Herrera LA, AlvarezRios E, GarciaMena J and Gariglio P: Resveratrol induces downregulation of DNA repair genes in MCF-7 human breast cancer cells. Eur J Cancer Prev. 22:11–20. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Fraser SP, Peters A, FlemingJones S, Mukhey D and Djamgoz MB: Resveratrol: Inhibitory effects on metastatic cell behaviors and voltage-gated Na+ channel activity in rat prostate cancer in vitro. Nutr Cancer. 66:1047–1058. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Mikula-Pietrasik J, Sosińska P and Książek K: Resveratrol inhibits ovarian cancer cell adhesion to peritoneal mesothelium in vitro by modulating the production of α5β1 integrins and hyaluronic acid. Gynecol Oncol. 134:624–630. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Chen YJ, Chen YY, Lin YF, Hu HY and Liao HF: Resveratrol inhibits alpha-melanocyte-stimulating hormone signaling, viability, and invasiveness in melanoma cells. Evid Based Complement Alternat Med. 2013:6321212013.PubMed/NCBI

36 

Wen S, Li H, Wu ML, Fan SH, Wang Q, Shu XH, Kong QY, Chen XY and Liu J: Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation. J Neurooncol. 104:169–177. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Magliano DC, Penna-de-Carvalho A, Vazquez-Carrera M, Mandarim-de-Lacerda CA and Aguila MB: Short-term administration of GW501516 improves inflammatory state in white adipose tissue and liver damage in high-fructose-fed mice through modulation of the renin-angiotensin system. Endocrine. 50:355–367. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Okamoto K, Tajima H, Nakanuma S, Sakai S, Makino I, Kinoshita J, Hayashi H, Nakamura K, Oyama K, Nakagawara H, et al: Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma. Int J Oncol. 41:573–582. 2012.PubMed/NCBI

39 

Kosaka T, Miyajima A, Takayama E, Kikuchi E, Nakashima J, Ohigashi T, Asano T, Sakamoto M, Okita H, Murai M and Hayakawa M: Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in prostate cancer. Prostate. 67:41–49. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Miyajima A, Kikuchi E, Kosaka T and Oya M: Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in urogenital cancer. Rev Recent Clin Trials. 4:75–78. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Miyajima A, Kosaka T, Asano T, Seta K, Kawai T and Hayakawa M: Angiotensin II type I antagonist prevents pulmonary metastasis of murine renal cancer by inhibiting tumor angiogenesis. Cancer Res. 62:4176–4179. 2002.PubMed/NCBI

42 

de Haas S, Delmar P, Bansal AT, Moisse M, Miles DW, Leighl N, Escudier B, Van Cutsem E, Carmeliet P, Scherer SJ, et al: Genetic variability of VEGF pathway genes in six randomized phase III trials assessing the addition of bevacizumab to standard therapy. Angiogenesis. 17:909–920. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Mittal K, Koon H, Elson P, Triozzi P, Dowlati A, Chen H, Borden EC and Rini BI: Dual VEGF/VEGFR inhibition in advanced solid malignancies: Clinical effects and pharmacodynamic biomarkers. Cancer Biol Ther. 15:975–981. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Chang WS, Liao CH, Miao CE, Wu HC, Hou LL, Hsiao CL, Ji HX, Tsai CW and Bau DT: The role of functional polymorphisms of cyclooxygenase 2 in renal cell carcinoma. Anticancer Res. 34:5481–5486. 2014.PubMed/NCBI

45 

He W, Zhang M, Zhao M, Davis LS, Blackwell TS, Yull F, Breyer MD and Hao CM: Increased dietary sodium induces COX2 expression by activating NFkB in renal medullary interstitial cells. Pflugers Arch. 466:357–367. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Fan L, Feng Y, Wan HY, Ni L, Qian YR, Guo Y, Xiang Y and Li QY: Hypoxia induces dysregulation of local renin-angiotensin system in mouse Lewis lung carcinoma cells. Genet Mol Res. 13:10562–10573. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Ino K, Shibata K, Kajiyama H, Nawa A, Nomura S and Kikkawa F: Manipulating the angiotensin system-new approaches to the treatment of solid tumours. Expert Opin Biol Ther. 6:243–255. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Araújo WF, Naves MA, Ravanini JN, Schor N and Teixeira VP: Renin-angiotensin system (RAS) blockade attenuates growth and metastatic potential of renal cell carcinoma in mice. Urol Oncol. 33:389.e1–e7. 2015. View Article : Google Scholar

49 

Childers WK: Interactions of the renin-angiotensin system in colorectal cancer and metastasis. Int J Colorectal Dis. 30:749–752. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li J, Qiu M, Chen L, Liu L, Tan G and Liu J: Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism. Oncol Lett 13: 613-620, 2017.
APA
Li, J., Qiu, M., Chen, L., Liu, L., Tan, G., & Liu, J. (2017). Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism. Oncology Letters, 13, 613-620. https://doi.org/10.3892/ol.2016.5519
MLA
Li, J., Qiu, M., Chen, L., Liu, L., Tan, G., Liu, J."Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism". Oncology Letters 13.2 (2017): 613-620.
Chicago
Li, J., Qiu, M., Chen, L., Liu, L., Tan, G., Liu, J."Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism". Oncology Letters 13, no. 2 (2017): 613-620. https://doi.org/10.3892/ol.2016.5519
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Qiu M, Chen L, Liu L, Tan G and Liu J: Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism. Oncol Lett 13: 613-620, 2017.
APA
Li, J., Qiu, M., Chen, L., Liu, L., Tan, G., & Liu, J. (2017). Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism. Oncology Letters, 13, 613-620. https://doi.org/10.3892/ol.2016.5519
MLA
Li, J., Qiu, M., Chen, L., Liu, L., Tan, G., Liu, J."Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism". Oncology Letters 13.2 (2017): 613-620.
Chicago
Li, J., Qiu, M., Chen, L., Liu, L., Tan, G., Liu, J."Resveratrol promotes regression of renal carcinoma cells via a renin‑angiotensin system suppression‑dependent mechanism". Oncology Letters 13, no. 2 (2017): 613-620. https://doi.org/10.3892/ol.2016.5519
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team