Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2017 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2017 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Characteristic expression of fukutin in gastric cancer among atomic bomb survivors

  • Authors:
    • Trang T.B. Pham
    • Naohide Oue
    • Manabu Yamamoto
    • Megumu Fujihara
    • Teruyoshi Ishida
    • Shoichiro Mukai
    • Naoya Sakamoto
    • Kazuhiro Sentani
    • Wataru Yasui
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734‑8551, Japan, Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Department of Pathology, Hiroshima Red Cross Hospital and Atomic‑Bomb Survivors Hospital, Hiroshima 730‑8619, Japan, Department of Surgery, Hiroshima Red Cross Hospital and Atomic‑Bomb Survivors Hospital, Hiroshima 730‑8619, Japan
  • Pages: 937-941
    |
    Published online on: December 20, 2016
       https://doi.org/10.3892/ol.2016.5520
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Approximately 70 years have passed since the atomic bombs were dropped on Nagasaki and Hiroshima. To elucidate potential biomarkers and possible mechanisms of radiation‑induced cancer, the expression of FKTN, which encodes fukutin protein and causes Fukuyama‑type congenital muscular dystrophy, was analyzed in gastric cancer (GC) tissue samples from atomic bomb survivors. Expression of cluster of differentiation (CD) 10 was also evaluated, as it has previously been observed that positive fukutin expression was frequently noted in CD10‑positive GC cases. In the first cohort from Hiroshima Red Cross Hospital and Atomic‑Bomb Survivors Hospital (Hiroshima, Japan; n=92), 102 (53%) of the GC cases were positive for fukutin. Expression of fukutin was not associated with exposure status, but was associated with CD10 expression (P=0.0001). The second cohort was from Hiroshima University Hospital (Hiroshima, Japan; n=86), and these patients were also in the Life Span Study cohort, in which atomic bomb radiation doses were precisely estimated using the DS02 system. Expression of fukutin was detected in 58 (67%) of GC cases. GC cases positive for fukutin were observed more frequently in the low dose‑exposed group than in the high dose‑exposed group (P=0.0001). Further studies with a larger cohort, including precise radiation dose estimation, may aid in clarifying whether fukutin could serve as a potential biomarker to define radiation‑induced GC in atomic‑bomb survivors.
View Figures

Figure 1

View References

1 

Thompson DE, Mabuchi K, Ron E, Soda M, Tokunaga M, Ochikubo S, Sugimoto S, Ikeda T, Terasaki M and Izumi S: Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958–1987. Radiat Res. 137:(2 Suppl). S17–S67. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Pierce DA, Shimizu Y, Preston DL, Vaeth M and Mabuchi K: Studies of the mortality of atomic bomb survivors. Report 12, Part I. Cancer: 1950–1990. 1996. Radiat Res. 146:61–87. 2012. View Article : Google Scholar

3 

Ozasa K, Shimizu Y, Suyama A, Kasagi F, Soda M, Grant EJ, Sakata R, Sugiyama H and Kodama K: Studies of the mortality of atomic bomb survivors, Report 14, 1950–2003: An overview of cancer and noncancer diseases. Radiat Res. 177:229–243. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Sakata R, Grant EJ, Furukawa K, Misumi M, Cullings H, Ozasa K and Shore RE: Long-term effects of the rain exposure shortly after the atomic bombings in Hiroshima and Nagasaki. Radiat Res. 182:599–606. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Global Burden of Disease Cancer Collaboration, . Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G and Woodbrook R: The global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Yasui W, Sentani K, Sakamoto N, Anami K, Naito Y and Oue N: Molecular pathology of gastric cancer: Research and practice. Pathol Res Pract. 207:608–612. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Preston DL, Shimizu Y, Pierce DA, Suyama A and Mabuchi K: Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950–1997. 2003. Radiat Res. 178:AV146–AV172. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, Mabuchi K and Kodama K: Solid cancer incidence in atomic bomb survivors: 1958–1998. Radiat Res. 168:1–64. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Takeshima Y, Seyama T, Bennett WP, Akiyama M, Tokuoka S, Inai K, Mabuchi K, Land CE and Harris CC: p53 mutations in lung cancers from non-smoking atomic-bomb survivors. Lancet. 342:1520–1521. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Takahashi K, Eguchi H, Arihiro K, Ito R, Koyama K, Soda M, Cologne J, Hayashi Y, Nakata Y, Nakachi K and Hamatani K: The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose. Mol Carcinog. 46:242–248. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Iwamoto KS, Mizuno T, Tokuoka S, Mabuchi K and Seyama T: Frequency of p53 mutations in hepatocellular carcinomas from atomic bomb survivors. J Natl Cancer Inst. 90:1167–1168. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Oue N, Sentani K, Sakamoto N, Motoshita J, Nishisaka T, Fukuhara T, Matsuura H, Sasaki H, Nakachi K and Yasui W: Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors. Int J Cancer. 124:1112–1121. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Naito Y, Oue N, Pham TT, Yamamoto M, Fujihara M, Ishida T, Mukai S, Sentani K, Sakamoto N, Hida E, et al: Characteristic miR-24 expression in gastric cancers among atomic bomb survivors. Pathobiology. 82:68–75. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Hinoi T, Okajima M, Graff JM and Yasui W: Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap: Expression of DSC2 in gastric cancer with intestinal phenotype. J Pathol. 221:275–284. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Oo HZ, Sentani K, Sakamoto N, Anami K, Naito Y, Oshima T, Yanagihara K, Oue N and Yasui W: Identification of novel transmembrane proteins in scirrhous-type gastric cancer by the Escherichia coli ampicillin secretion trap (CAST) method: TM9SF3 participates in tumor invasion and serves as a prognostic factor. Pathobiology. 81:138–148. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Oue N, Sentani K, Sakamoto N and Yasui W: Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype. Cancer Sci. 106:951–958. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Oo HZ, Sentani K, Mukai S, Hattori T, Shinmei S, Goto K, Sakamoto N, Naito Y, Anami K, Trang PT, et al: Fukutin, identified by the Escherichia coli ampicillin secretion trap (CAST) method, participates in tumor progression in gastric cancer. Gastric Cancer. 19:443–452. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Kobayashi K, Nakahori Y, Miyake M, Matsumura K, KondoIida E, Nomura Y, Segawa M, Yoshioka M, Saito K, Osawa M, et al: An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature. 394:388–392. 1998. View Article : Google Scholar : PubMed/NCBI

20 

Preston DL, Pierce DA, Shimizu Y, Cullings HM, Fujita S, Funamoto S and Kodama K: Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates. Radiat Res. 162:377–389. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Sobin LH and Compton CC: TNM seventh edition: What's new, what's changed: Communication from the international union against cancer and the American Joint Committee on Cancer. Cancer. 116:5336–5339. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Lauren P: The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 64:31–49. 1965.PubMed/NCBI

23 

Cullings HM, Fujita S, Funamoto S, Grant EJ, Kerr GD and Preston DL: Dose estimation for atomic bomb survivor studies: Its evolution and present status. Radiat Res. 166:219–254. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Straume T, Rugel G, Marchetti AA, Rühm W, Korschinek G, McAninch JE, Carroll K, Egbert S, Faestermann T, Knie K, et al: Measuring fast neutrons in Hiroshima at distances relevant to atomic-bomb survivors. Nature. 424:539–542. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Saito F, Masaki T, Saito Y, Nakamura A, Takeda S, Shimizu T, Toda T and Matsumura K: Defective peripheral nerve myelination and neuromuscular junction formation in fukutin-deficient chimeric mice. J Neurochem. 101:1712–1722. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pham TT, Oue N, Yamamoto M, Fujihara M, Ishida T, Mukai S, Sakamoto N, Sentani K and Yasui W: Characteristic expression of fukutin in gastric cancer among atomic bomb survivors. Oncol Lett 13: 937-941, 2017.
APA
Pham, T.T., Oue, N., Yamamoto, M., Fujihara, M., Ishida, T., Mukai, S. ... Yasui, W. (2017). Characteristic expression of fukutin in gastric cancer among atomic bomb survivors. Oncology Letters, 13, 937-941. https://doi.org/10.3892/ol.2016.5520
MLA
Pham, T. T., Oue, N., Yamamoto, M., Fujihara, M., Ishida, T., Mukai, S., Sakamoto, N., Sentani, K., Yasui, W."Characteristic expression of fukutin in gastric cancer among atomic bomb survivors". Oncology Letters 13.2 (2017): 937-941.
Chicago
Pham, T. T., Oue, N., Yamamoto, M., Fujihara, M., Ishida, T., Mukai, S., Sakamoto, N., Sentani, K., Yasui, W."Characteristic expression of fukutin in gastric cancer among atomic bomb survivors". Oncology Letters 13, no. 2 (2017): 937-941. https://doi.org/10.3892/ol.2016.5520
Copy and paste a formatted citation
x
Spandidos Publications style
Pham TT, Oue N, Yamamoto M, Fujihara M, Ishida T, Mukai S, Sakamoto N, Sentani K and Yasui W: Characteristic expression of fukutin in gastric cancer among atomic bomb survivors. Oncol Lett 13: 937-941, 2017.
APA
Pham, T.T., Oue, N., Yamamoto, M., Fujihara, M., Ishida, T., Mukai, S. ... Yasui, W. (2017). Characteristic expression of fukutin in gastric cancer among atomic bomb survivors. Oncology Letters, 13, 937-941. https://doi.org/10.3892/ol.2016.5520
MLA
Pham, T. T., Oue, N., Yamamoto, M., Fujihara, M., Ishida, T., Mukai, S., Sakamoto, N., Sentani, K., Yasui, W."Characteristic expression of fukutin in gastric cancer among atomic bomb survivors". Oncology Letters 13.2 (2017): 937-941.
Chicago
Pham, T. T., Oue, N., Yamamoto, M., Fujihara, M., Ishida, T., Mukai, S., Sakamoto, N., Sentani, K., Yasui, W."Characteristic expression of fukutin in gastric cancer among atomic bomb survivors". Oncology Letters 13, no. 2 (2017): 937-941. https://doi.org/10.3892/ol.2016.5520
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team