Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 13 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Characteristics and outcome of laryngeal squamous cell carcinoma in young adults

  • Authors:
    • Yuval Nachalon
    • Ohad Cohen
    • Uri Alkan
    • Jacob Shvero
    • Aron Popovtzer
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology‑Head and Neck Surgery, Rabin Medical Center, Beilinson Hospital, Petah Tikva 4941492, Israel, Department of Clinical Otolaryngology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
  • Pages: 1393-1397
    |
    Published online on: December 21, 2016
       https://doi.org/10.3892/ol.2016.5528
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Laryngeal carcinoma rarely occurs in the young adult population. Therefore, the optimal treatment for this age group is unclear, specifically regarding organ preservation treatment. In order to assess the distinct characteristics of laryngeal squamous cell carcinoma (SCC) in young adults and describe the effect of treatment on survival, a retrospective chart review of all patients aged <40 years, who were treated in a tertiary referral center for laryngeal SCC between January 1960 and December 2013, was performed. Patients who were treated prior to and following the Veterans study, representing an arbitrary point which started the organ preservation era, were compared. A total of 29 patients (male:female ratio, 2.6:1) were identified. The mean age at diagnosis was 35±5 years and 17 patients (59%) were smokers. In total, 12 (41%) of patients were stage I, 4 (14%) were stage II, 8 (28%) were stage III and 5 (17%) were stage IV. Glottic tumors were present in 20 (69%) of patients and supraglottic tumors in 6 (21%); the site of tumor origin could not be determined in 3 (10%) of patients. Surgery was performed in 11 (38%) of patients, radiation in 21 (72%) and chemotherapy in 5 (17%). A comparison between patients treated prior to and following the Veterans study demonstrated a 2‑year higher laryngectomy‑free survival rate of 53% and 78%, respectively (P=0.299). The 2‑year disease‑free survival rate was 93% for patients who were treated prior to the Veterans study and 71% for patients who were treated after (P=0.001), with no significant change in overall survival (P=0.413). The results suggest that the characteristics and behavior of laryngeal carcinoma in young adults is similar to older adults. Higher rates of 2‑year laryngectomy‑free survival were noted in patients treated following the organ preservation era with no significant difference in survival compared with patients who were treated before.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Muscat JE and Wynder EL: Tobacco, alcohol, asbestos, and occupational risk factors for laryngeal cancer. Cancer. 69:2244–2251. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Menvielle G, Luce D, Goldberg P, Bugel I and Leclerc A: Smoking, alcohol drinking and cancer risk for various sites of the larynx and hypopharynx. A case-control study in France. Eur J Cancer Prev. 13:165–172. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Singh B, Alfonso A, Sabin S, Poluri A, Shaha AR, Sundaram K and Lucente FE: Outcome differences in younger and older patients with laryngeal cancer: A retrospective case-control study. Am J Otolaryngol. 21:92–97. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Shvero J, Hadar T, Segal K, Abraham A and Sidi J: Laryngeal carcinoma in patients 40 years of age and younger. Cancer. 60:3092–3095. 1987. View Article : Google Scholar : PubMed/NCBI

6 

Li X, Gao L, Li H, Gao J, Yang Y, Zhou F, Gao C, Li M and Jin Q: Human papillomavirus infection and laryngeal cancer risk: A systematic review and meta-analysis. J Infect Dis. 207:479–488. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Koskinen WJ, Brøndbo K, Dahlstrand H Mellin, Luostarinen T, Hakulinen T, Leivo I, Molijn A, Quint WG, Røysland T, Munck-Wikland E, et al: Alcohol, smoking and human papillomavirus in laryngeal carcinoma: A Nordic prospective multicenter study. J Cancer Res Clin Oncol. 133:673–678. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Baumann JL, Cohen S, Evjen AN, Law JH, Vadivelu S, Attia A, Schindler JS, Chung CH, Wirth PS, Meijer CJ, et al: Human papillomavirus in early laryngeal carcinoma. Laryngoscope. 119:1531–1537. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Coca-Pelaz A, Rodrigo JP, Takes RP, Silver CE, Paccagnella D, Rinaldo A, Hinni ML and Ferlito A: Relationship between reflux and laryngeal cancer. Head Neck. 35:1814–1818. 2013. View Article : Google Scholar : PubMed/NCBI

10 

No authors listed, . Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The department of veterans affairs laryngeal cancer study group. N Engl J Med. 324:1685–1690. 1991. View Article : Google Scholar : PubMed/NCBI

11 

Herrero R, Castellsagué X, Pawlita M, Lissowska J, Kee F, Balaram P, Rajkumar T, Sridhar H, Rose B, Pintos J, et al: Human papillomavirus and oral cancer: The International Agency for Research on Cancer multicenter study. J Natl Cancer Inst. 95:1772–1783. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Levi F, Pasche C, Lucchini F, Bosetti C and La Vecchia C: Processed meat and the risk of selected digestive tract and laryngeal neoplasms in Switzerland. Ann Oncol. 15:346–349. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Luna-Ortiz K, VillavicencioValencia V, Pasche P, LavinLozano A and Herrera-Gómeza Á: Laryngeal cancer in patients younger vs older than 40 years old: A matched-paired analysis. Acta Otorrinolaringologica Esp. 62:113–118. 2011.(In Spanish). View Article : Google Scholar

14 

van Dijk BA, KarimKos HE, Coebergh JW, Marres HA and de Vries E: Progress against laryngeal cancer in The Netherlands between 1989 and 2010. Int J Cancer. 134:674–681. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Hoffman HT, Porter K, Karnell LH, Cooper JS, Weber RS, Langer CJ, Ang KK, Gay G, Stewart A and Robinson RA: Laryngeal cancer in the United States: Changes in demographics, patterns of care and survival. Laryngoscope. 116:(9 Pt 2 Suppl 111). 1–13. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Lipkin A, Miller RH and Woodson GE: Squamous cell carcinoma of the oral cavity, pharynx, and larynx in young adults. Laryngoscope. 95:790–793. 1985. View Article : Google Scholar : PubMed/NCBI

17 

Verschuur HP, Irish JC, O'Sullivan B, Goh C, Gullane PJ and Pintilie M: A matched control study of treatment outcome in young patients with squamous cell carcinoma of the head and neck. Laryngoscope. 109:249–258. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Reizenstein JA, Bergström SN, Holmberg L, Linder A, Ekman S, Blomquist E, Lödén B, Holmqvist M, Hellström K, Nilsson CO, et al: Impact of age at diagnosis on prognosis and treatment in laryngeal cancer. Head Neck;. 32:1062–1068. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Rutt AL, Hawkshaw MJ and Sataloff RT: Laryngeal cancer in patients younger than 30 years: A review of 99 cases. Ear Nose Throat J. 89:189–192. 2010.PubMed/NCBI

20 

Petrović Z, Stojcić G and Jesić S: Laryngeal carcinoma in younger patients. J Laryngol Otol. 110:934–936. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Misono S, Marmor S, Yueh B and Virnig BA: Treatment and survival in 10,429 patients with localized laryngeal cancer: A population-based analysis. Cancer. 120:1810–1817. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, et al: Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 349:2091–2097. 2003. View Article : Google Scholar : PubMed/NCBI

23 

American Society of Clinical Oncology, . Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ, Ang KK, Clayman GL, Fisher SG, Forastiere AA, et al: American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol. 24:3693–3704. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Forastiere AA: Larynx preservation and survival trends: Should there be concern? Head Neck. 32:14–17. 2010.PubMed/NCBI

25 

Lee-Preston V, Steen IN, Dear A, Kelly CG, Welch AR, Meikle D, Stafford FW and Wilson JA: Optimizing the assessment of quality of life after laryngeal cancer treatment. J Laryngol Otol. 118:432–438. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Fujita M, Rudoltz M, Canady DJ, Patel P, Machtay M, Pittard MQ, Mohiuddin M and Regine WF: Second malignant neoplasia in patients with T1 glottic cancer treated with radiation. Laryngoscope. 108:1853–1855. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Holland JM, Arsanjani A, Liem BJ, Hoffelt SC, Cohen JI and Stevens KR Jr: Second malignancies in early stage laryngeal carcinoma patients treated with radiotherapy. J Laryngol Otol. 116:190–193. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Albright JT, Karpati R, Topham AK, Spiegel JR and Sataloff RT: Second malignant neoplasms in patients under 40 years of age with laryngeal cancer. Laryngoscope. 111:563–567. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nachalon Y, Cohen O, Alkan U, Shvero J and Popovtzer A: Characteristics and outcome of laryngeal squamous cell carcinoma in young adults. Oncol Lett 13: 1393-1397, 2017.
APA
Nachalon, Y., Cohen, O., Alkan, U., Shvero, J., & Popovtzer, A. (2017). Characteristics and outcome of laryngeal squamous cell carcinoma in young adults. Oncology Letters, 13, 1393-1397. https://doi.org/10.3892/ol.2016.5528
MLA
Nachalon, Y., Cohen, O., Alkan, U., Shvero, J., Popovtzer, A."Characteristics and outcome of laryngeal squamous cell carcinoma in young adults". Oncology Letters 13.3 (2017): 1393-1397.
Chicago
Nachalon, Y., Cohen, O., Alkan, U., Shvero, J., Popovtzer, A."Characteristics and outcome of laryngeal squamous cell carcinoma in young adults". Oncology Letters 13, no. 3 (2017): 1393-1397. https://doi.org/10.3892/ol.2016.5528
Copy and paste a formatted citation
x
Spandidos Publications style
Nachalon Y, Cohen O, Alkan U, Shvero J and Popovtzer A: Characteristics and outcome of laryngeal squamous cell carcinoma in young adults. Oncol Lett 13: 1393-1397, 2017.
APA
Nachalon, Y., Cohen, O., Alkan, U., Shvero, J., & Popovtzer, A. (2017). Characteristics and outcome of laryngeal squamous cell carcinoma in young adults. Oncology Letters, 13, 1393-1397. https://doi.org/10.3892/ol.2016.5528
MLA
Nachalon, Y., Cohen, O., Alkan, U., Shvero, J., Popovtzer, A."Characteristics and outcome of laryngeal squamous cell carcinoma in young adults". Oncology Letters 13.3 (2017): 1393-1397.
Chicago
Nachalon, Y., Cohen, O., Alkan, U., Shvero, J., Popovtzer, A."Characteristics and outcome of laryngeal squamous cell carcinoma in young adults". Oncology Letters 13, no. 3 (2017): 1393-1397. https://doi.org/10.3892/ol.2016.5528
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team