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Article

Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity

  • Authors:
    • Douglas R. Abdalla
    • Bruno B. M. Gomes
    • Eddie F. C. Murta
    • Márcia A. Michelin
  • View Affiliations / Copyright

    Affiliations: Oncology Research Institute, Federal University of the Triângulo Mineiro, Uberaba, MG 38025‑180, Brazil, Discipline of Gynecology and Obstetrics, Oncology Research Institute, Federal University of the Triângulo Mineiro, Uberaba, MG 38025‑180, Brazil, Discipline of Immunology, Oncology Research Institute, Federal University of the Triângulo Mineiro, Uberaba, MG 38025‑180, Brazil
  • Pages: 1406-1410
    |
    Published online on: January 11, 2017
       https://doi.org/10.3892/ol.2017.5589
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Abstract

Immune cells are required in the immune response against tumours, although sometimes without success. The present study aimed to investigate dendritic cell (DC) maturation in animals with induced immunosuppression that were subjected to physical activity (PA). Immunosuppression was induced using 7,12‑dimethyl‑benzanthracene (DMBA). A total of 56 Balb/c mice were divided into four groups, including the control group, non‑DMBA administered/PA group (GII), DMBA administered/non‑PA group (GIII) and the DMBA administered/PA group (GIV). Bone marrow was removed from the leg bones following sacrifice. Bone marrow‑derived DCs were stimulated to differentiate by granulocyte‑macrophage colony-stimulating factor, interleukin (IL)‑4 and tumour necrosis factor‑α, after which the phenotype was assessed by flow cytometry and the cytokine profile was assessed using ELISAs. PA significantly increased the percentage of DCs in GII (55.38±2.63%) and GIV (50.1±3.1%) mice, as compared with GI (34.61±1.28%) and GIII (36.25±1.85%) mice (P<0.05). In addition, GIV mice showed a significantly higher level of cluster of differentiation (CD) 80+/CD86+ DCs (76.38±6.31%), as compared with GI (54.03±6.52%) and GIII (52.07±5.74%) mice (P<0.05). Furthermore, GIV mice showed a significantly higher level of CD80+/major histocompatibility complex class II double labelling (P<0.05), as compared with GIV (95.35±1.22%) and GIII (76.15±5.53%) mice. The expression of interferon‑γ was significantly increased in GIV mice [5.89 (5.2‑7.12)], as compared with GIII mice [2.75 (1.33‑4.4)] (P<0.05). Similarly, the expression of IL‑12 was markedly increased in GIV mice [1.27 (0.26‑2.57)] compared with GIII mice [0.73 (0.44‑1.47)], although the difference was not significant (P=0.063). The results of the present study suggested that PA was able to promote the maturation of DCs and their secretion of anti‑tumour cytokines. Therefore, PA may emerge as a tool in immunotherapy.
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1 

Ashley DM, Faiola B, Nair S, Hale LP, Bigner DD and Gilboa E: Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induced antitumor immunity against central nervous system tumors. J Exp Med. 186:1177–1182. 1997. View Article : Google Scholar : PubMed/NCBI

2 

Banchereau J and Steinman RM: Dendritic cells and the control of immunity. Nature. 392:245–252. 1998. View Article : Google Scholar : PubMed/NCBI

3 

Fields RC, Shimizu K and Mulé JJ: Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. Proc Natl Acad Sci USA. 95:9482–9487. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Zitvogel LZ, Mayordomo JI, Tjandrawan T, DeLeo AB, Clarke MR, Lotze MT and Storkus WJ: Therapy of murine tumors with tumor peptidepulsed dendritic cells: Dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J Exp Med. 183:87–97. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Gabrilovich DI, Chen HL, Girgis KR, Cunningham HT, Meny GM, Nadaf S, Kavanaugh D and Carbone DP: Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med. 2:1096–1103. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Gastl GA, Abrams JS, Nanus DM, Oosterkamp R, Silver J, Liu F, Chen M, Albino AP and Bander NH: Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression. Int J Cancer. 55:96–101. 1993. View Article : Google Scholar : PubMed/NCBI

7 

Kavanaugh DY and Carbone DP: Immunologic dysfunction in cancer. Hematol Oncol Clin North Am. 10:927–951. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Wojtowicz-Praga S: Reversal of tumor-induced immunosuppression: A new approach to cancer therapy. J Immunother. 20:165–177. 1997. View Article : Google Scholar : PubMed/NCBI

9 

LaVoy EC, Bollard CM, Hanley PJ, O'Connor DP, Lowder TW, Bosch JA and Simpson RJ: A single bout of dynamic exercise by healthy adults enhances the generation of monocyte-derived-dendritic cells. Cell Immunol. 295:52–59. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Blannin AK, Gleeson M and Brooks S: Effect of lactacidosis on human leucocyte adherence: A possible explanation of why the leucocyte count continues to rise after cessation of very high intensity exerciseGleeson M: Immune function in sport and exercise. Philadelphia: Elsevier; pp. 67–89. 2006, View Article : Google Scholar

11 

Fairey AS, Courneya KS, Field CJ and Mackey JR: Physical exercise and immune system function in cancer survivors. Cancer. 94:539–551. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Woods JA: Physical activity, exercise, and immune function. Brain Behav Immun. 19:369–370. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Petersen AM and Pedersen BK: The anti-inflammation effect of exercise. J Appl Physiol (1985). 98:1154–1162. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Cleveland RJ, Eng SM, Stevens J, Bradshaw PT, Teitelbaum SL, Neugut AI and Gammon MD: Influence of prediagnostic recreational physical activity on survival from breast câncer. Eur J Cancer Prev. 21:46–54. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Friedenreich CM and Rohan TE: Physical activity and risk of breast cancer. Eur J Cancer Prev. 4:145–151. 1995. View Article : Google Scholar : PubMed/NCBI

16 

LaVoy EC, Bollard CM, Hanley PJ, O'Connor DP, Bosch JA and Simpson RJ: A single bout of dynamic exercise enhances the expansion of MAGE-A4 and PRAME-specific cytotoxic t-cells from healthy adults. Exerc Immunol Rev. 21:144–153. 2015.PubMed/NCBI

17 

Abdalla DR, Murta EF and Michelin MA: The influence of physical activity on the profile of immune response cells and cytokine synthesis in mice with experimental breast tumors induced by 7,12-dimethylbenzanthracene. Eur J Cancer Prev. 22:251–258. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Abdalla DR, Aleixo AA, Murta EF and Michelin MA: Innate immune response adaptation in mice subjected to administration of DMBA and physical activity. Oncol Lett. 7:886–890. 2014.PubMed/NCBI

19 

Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert JD, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, et al: Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells. Cancer Res. 72:2757–2767. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Goh J, Endicott E and Ladiges WC: Pre-tumor exercise decreases breast cancer in old mice in a distance-dependent manner. Am J Cancer Res. 4:378–384. 2014.PubMed/NCBI

21 

Buehlmeyer K, Doering F, Daniel H, Kindermann B, Schulz T and Michna H: Alteration of gene expression in rat colon mucosa after exercise. Ann Anat. 190:71–80. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Lane HW, Keith RE, Strahan S and White MT: The effect of diet, exercise and 7,12-dimethylbenz(a)anthracene on food intake, body composition and carcass energy levels in female virgin BALB/c mice. J Nutr. 121:1876–1882. 1991.PubMed/NCBI

23 

Thompson HJ, Ronan AM, Ritacco KA, Tagliaferro AR and Meeker LD: Effect of exercise on the induction of mammary carcinogenesis. Cancer Res. 48:2720–2723. 1988.PubMed/NCBI

24 

Asavaroengchai W, Kotera Y and Mulé JJ: Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery. Proc Natl Acad Sci USA. 99:931–936. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Chiang LM, Chen YJ, Chiang J, Lai LY, Chen YY and Liao HF: Modulation of dendritic cells by endurance training. Int J Sports Med. 28:798–803. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Liao HF, Chiang LM, Yen CC, Chen YY, Zhuang RR, Lai LY, Chiang J and Chen YJ: Effect of a periodized exercise training and active recovery program on antitumor activity and development of dendritic cells. J Sports Med Phys Fitness. 46:307–314. 2006.PubMed/NCBI

27 

Ru W and Peijie C: Modulation of dendritic cells and NKT cells excessive exercise in rats. J Med Biol Eng. 29:190–194. 2009.

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Copy and paste a formatted citation
Spandidos Publications style
Abdalla DR, Gomes BB, Murta EF and Michelin MA: Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity. Oncol Lett 13: 1406-1410, 2017.
APA
Abdalla, D.R., Gomes, B.B., Murta, E.F., & Michelin, M.A. (2017). Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity. Oncology Letters, 13, 1406-1410. https://doi.org/10.3892/ol.2017.5589
MLA
Abdalla, D. R., Gomes, B. B., Murta, E. F., Michelin, M. A."Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity". Oncology Letters 13.3 (2017): 1406-1410.
Chicago
Abdalla, D. R., Gomes, B. B., Murta, E. F., Michelin, M. A."Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity". Oncology Letters 13, no. 3 (2017): 1406-1410. https://doi.org/10.3892/ol.2017.5589
Copy and paste a formatted citation
x
Spandidos Publications style
Abdalla DR, Gomes BB, Murta EF and Michelin MA: Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity. Oncol Lett 13: 1406-1410, 2017.
APA
Abdalla, D.R., Gomes, B.B., Murta, E.F., & Michelin, M.A. (2017). Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity. Oncology Letters, 13, 1406-1410. https://doi.org/10.3892/ol.2017.5589
MLA
Abdalla, D. R., Gomes, B. B., Murta, E. F., Michelin, M. A."Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity". Oncology Letters 13.3 (2017): 1406-1410.
Chicago
Abdalla, D. R., Gomes, B. B., Murta, E. F., Michelin, M. A."Bone marrow‑derived dendritic cells under influence of experimental breast cancer and physical activity". Oncology Letters 13, no. 3 (2017): 1406-1410. https://doi.org/10.3892/ol.2017.5589
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