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Article

High BIM mRNA levels are associated with longer survival in advanced gastric cancer

  • Authors:
    • Nandie Wu
    • Ying Huang
    • Zhengyun Zou
    • Ana Gimenez‑Capitan
    • Lixia Yu
    • Wenjing Hu
    • Lijing Zhu
    • Xia Sun
    • Jose Javier Sanchez
    • Wenxian Guan
    • Baorui Liu
    • Rafael Rosell
    • Jia Wei
  • View Affiliations / Copyright

    Affiliations: The Comprehensive Cancer Centre of Drum Tower Hospital, Department of Oncology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu 210008, P.R. China, Pangaea Biotech, Department of Oncology, USP Dexeus University Institute, Barcelona 08001, Spain, Department of Preventive Medicine and Public Health, Autonomous University of Madrid, Madrid 28001, Spain, Department of General Surgery, The Affiliated Drum Tower Hospital of Nanjing University, Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China
  • Pages: 1826-1834
    |
    Published online on: February 1, 2017
       https://doi.org/10.3892/ol.2017.5660
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Abstract

Chemotherapy drugs, including 5-fluorouracil (5-FU), oxaliplatin and docetaxel, are commonly used in the treatment of gastric cancer (GC). Apoptosis‑relevant genes may be associated with drug resistance. In the present study, the messenger RNA (mRNA) expression levels of B‑cell lymphoma 2 interacting mediator of cell death (BIM), astrocyte elevated gene‑1 (AEG‑1) and AXL receptor tyrosine kinase (AXL) were investigated in 131 advanced GC samples, and the expression levels of these genes were correlated with patients' overall survival (OS). All 131 patients received first‑line FOLFOX combination chemotherapy with folinic acid and 5‑FU, in which 56 patients were further treated with second‑line docetaxel‑based chemotherapy. A correlation between the mRNA expression levels of BIM and AEG‑1 was observed (rs=0.30; P=0.002). There was no association between the mRNA expression levels of any of the individual genes analyzed and OS in patients only receiving first‑line FOLFOX chemotherapy. In a subgroup of patients receiving docetaxel‑based second‑line chemotherapy, those with high or intermediate levels of BIM exhibited a median OS of 18.2 months [95% confidence interval (CI), 12.8‑23.6], compared with 9.6 months (95% CI, 8.9‑10.3) in patients with low BIM levels (P=0.008). However, there was no correlation between the mRNA expression levels of AEG‑1 or AXL and OS. The risk of mortality was higher in patients with low BIM mRNA levels than in those with high or intermediate BIM mRNA levels (hazard ratio, 2.61; 95% CI, 1.21‑5.62; P=0.010). Therefore, BIM may be considered as a biomarker to identify whether patients could benefit from docetaxel-based second‑line chemotherapy in GC.
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Copy and paste a formatted citation
Spandidos Publications style
Wu N, Huang Y, Zou Z, Gimenez‑Capitan A, Yu L, Hu W, Zhu L, Sun X, Sanchez JJ, Guan W, Guan W, et al: High BIM mRNA levels are associated with longer survival in advanced gastric cancer. Oncol Lett 13: 1826-1834, 2017.
APA
Wu, N., Huang, Y., Zou, Z., Gimenez‑Capitan, A., Yu, L., Hu, W. ... Wei, J. (2017). High BIM mRNA levels are associated with longer survival in advanced gastric cancer. Oncology Letters, 13, 1826-1834. https://doi.org/10.3892/ol.2017.5660
MLA
Wu, N., Huang, Y., Zou, Z., Gimenez‑Capitan, A., Yu, L., Hu, W., Zhu, L., Sun, X., Sanchez, J. J., Guan, W., Liu, B., Rosell, R., Wei, J."High BIM mRNA levels are associated with longer survival in advanced gastric cancer". Oncology Letters 13.3 (2017): 1826-1834.
Chicago
Wu, N., Huang, Y., Zou, Z., Gimenez‑Capitan, A., Yu, L., Hu, W., Zhu, L., Sun, X., Sanchez, J. J., Guan, W., Liu, B., Rosell, R., Wei, J."High BIM mRNA levels are associated with longer survival in advanced gastric cancer". Oncology Letters 13, no. 3 (2017): 1826-1834. https://doi.org/10.3892/ol.2017.5660
Copy and paste a formatted citation
x
Spandidos Publications style
Wu N, Huang Y, Zou Z, Gimenez‑Capitan A, Yu L, Hu W, Zhu L, Sun X, Sanchez JJ, Guan W, Guan W, et al: High BIM mRNA levels are associated with longer survival in advanced gastric cancer. Oncol Lett 13: 1826-1834, 2017.
APA
Wu, N., Huang, Y., Zou, Z., Gimenez‑Capitan, A., Yu, L., Hu, W. ... Wei, J. (2017). High BIM mRNA levels are associated with longer survival in advanced gastric cancer. Oncology Letters, 13, 1826-1834. https://doi.org/10.3892/ol.2017.5660
MLA
Wu, N., Huang, Y., Zou, Z., Gimenez‑Capitan, A., Yu, L., Hu, W., Zhu, L., Sun, X., Sanchez, J. J., Guan, W., Liu, B., Rosell, R., Wei, J."High BIM mRNA levels are associated with longer survival in advanced gastric cancer". Oncology Letters 13.3 (2017): 1826-1834.
Chicago
Wu, N., Huang, Y., Zou, Z., Gimenez‑Capitan, A., Yu, L., Hu, W., Zhu, L., Sun, X., Sanchez, J. J., Guan, W., Liu, B., Rosell, R., Wei, J."High BIM mRNA levels are associated with longer survival in advanced gastric cancer". Oncology Letters 13, no. 3 (2017): 1826-1834. https://doi.org/10.3892/ol.2017.5660
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