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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article Open Access

CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells

  • Authors:
    • Yuan Tian
    • Yan Song
    • Weiliang Bai
    • Xiulan Ma
    • Zhong Ren

  • View Affiliations / Copyright

    Affiliations: The First Department of Otolaryngology (Department of Otology), Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, The Second Department of Otolaryngology (Department of Rhinology), Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2253-2259
    |
    Published online on: February 8, 2017
       https://doi.org/10.3892/ol.2017.5694
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Abstract

Nasopharyngeal cancer is a type of malignant tumor with a high rate of incidence. Cancer stem cells are regarded as one of the main causes for the formation and recurrence of nasopharyngeal cancer. CXC chemokine receptor type 4 (CXCR4) has been reported to perform an important role in cancer; however, the association between CXCR4 and nasopharyngeal cancer stem cells remains unclear. The present study explored the effect of CXCR4 on cellular viability, apoptosis and invasion of nasopharyngeal cancer stem cells. Results of the present study demonstrated that knockdown of CXCR4 inhibited the viability and invasion of nasopharyngeal cancer stem cells and promoted cellular apoptosis. Further studies have revealed that the anti‑tumor effect of CXCR4 knockdown was associated with the inhibition of the protein kinase B signal. These results demonstrate that the knockdown of CXCR4 resulted in an anti‑tumor effect in nasopharyngeal cancer stem cells. Therefore, CXCR4 may become a promising therapeutic target in the treatment of nasopharyngeal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Tian Y, Song Y, Bai W, Ma X and Ren Z: CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells. Oncol Lett 13: 2253-2259, 2017.
APA
Tian, Y., Song, Y., Bai, W., Ma, X., & Ren, Z. (2017). CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells. Oncology Letters, 13, 2253-2259. https://doi.org/10.3892/ol.2017.5694
MLA
Tian, Y., Song, Y., Bai, W., Ma, X., Ren, Z."CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells". Oncology Letters 13.4 (2017): 2253-2259.
Chicago
Tian, Y., Song, Y., Bai, W., Ma, X., Ren, Z."CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells". Oncology Letters 13, no. 4 (2017): 2253-2259. https://doi.org/10.3892/ol.2017.5694
Copy and paste a formatted citation
x
Spandidos Publications style
Tian Y, Song Y, Bai W, Ma X and Ren Z: CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells. Oncol Lett 13: 2253-2259, 2017.
APA
Tian, Y., Song, Y., Bai, W., Ma, X., & Ren, Z. (2017). CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells. Oncology Letters, 13, 2253-2259. https://doi.org/10.3892/ol.2017.5694
MLA
Tian, Y., Song, Y., Bai, W., Ma, X., Ren, Z."CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells". Oncology Letters 13.4 (2017): 2253-2259.
Chicago
Tian, Y., Song, Y., Bai, W., Ma, X., Ren, Z."CXCR4 knockdown inhibits the growth and invasion of nasopharyngeal cancer stem cells". Oncology Letters 13, no. 4 (2017): 2253-2259. https://doi.org/10.3892/ol.2017.5694
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