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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Study of the expression and function of ACY1 in patients with colorectal cancer

  • Authors:
    • Bing Yu
    • Xuezhong Liu
    • Xiuzhen Cao
    • Mingyue Zhang
    • Hong Chang

  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Gastrointestinal Surgery, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China, Department of Colorectal Surgery, Tai'an Central Hospital, Tai'an, Shandong 271000, P.R. China
  • Pages: 2459-2464
    |
    Published online on: February 8, 2017
       https://doi.org/10.3892/ol.2017.5702
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Abstract

Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples were collected for analysis from 132 patients diagnosed with colorectal cancer. Reverse transcription‑quantitative polymerase chain reaction analysis and western blotting identified significantly increased expression of ACY1 mRNA in colorectal tumor tissue (P<0.05 vs. adjacent normal tissue) and notably increased ACY1 protein levels. This ACY1 mRNA expression was found to be positively correlated with tumor stage. In addition, plasma ACY1 concentration was increased in patients with colorectal cancer compared with healthy controls. Furthermore, in vitro knockdown of ACY1 in human colorectal cancer HT‑29 cells was shown to inhibit proliferation and increase apoptosis. This effect was found to be associated with the activation of ERK1 and TGF‑β1 signaling. In conclusion, the results of the present study suggest that ACY1 promotes tumor progression, and thus may be a potential target for the diagnosis and treatment of colorectal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Yu B, Liu X, Cao X, Zhang M and Chang H: Study of the expression and function of ACY1 in patients with colorectal cancer. Oncol Lett 13: 2459-2464, 2017.
APA
Yu, B., Liu, X., Cao, X., Zhang, M., & Chang, H. (2017). Study of the expression and function of ACY1 in patients with colorectal cancer. Oncology Letters, 13, 2459-2464. https://doi.org/10.3892/ol.2017.5702
MLA
Yu, B., Liu, X., Cao, X., Zhang, M., Chang, H."Study of the expression and function of ACY1 in patients with colorectal cancer". Oncology Letters 13.4 (2017): 2459-2464.
Chicago
Yu, B., Liu, X., Cao, X., Zhang, M., Chang, H."Study of the expression and function of ACY1 in patients with colorectal cancer". Oncology Letters 13, no. 4 (2017): 2459-2464. https://doi.org/10.3892/ol.2017.5702
Copy and paste a formatted citation
x
Spandidos Publications style
Yu B, Liu X, Cao X, Zhang M and Chang H: Study of the expression and function of ACY1 in patients with colorectal cancer. Oncol Lett 13: 2459-2464, 2017.
APA
Yu, B., Liu, X., Cao, X., Zhang, M., & Chang, H. (2017). Study of the expression and function of ACY1 in patients with colorectal cancer. Oncology Letters, 13, 2459-2464. https://doi.org/10.3892/ol.2017.5702
MLA
Yu, B., Liu, X., Cao, X., Zhang, M., Chang, H."Study of the expression and function of ACY1 in patients with colorectal cancer". Oncology Letters 13.4 (2017): 2459-2464.
Chicago
Yu, B., Liu, X., Cao, X., Zhang, M., Chang, H."Study of the expression and function of ACY1 in patients with colorectal cancer". Oncology Letters 13, no. 4 (2017): 2459-2464. https://doi.org/10.3892/ol.2017.5702
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