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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis

  • Authors:
    • Hai‑Peng Ren
    • Xiao‑Yan Yin
    • Hai‑Ying Yu
    • Hai‑Feng Xiao

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Weifang People's Hospital of Shandong Province, Weifang, Shandong 261041, P.R. China, Weifang Kuiwen District Family Planning of Health Inspection Team, Weifang, Shandong 261041, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2337-2343
    |
    Published online on: February 14, 2017
       https://doi.org/10.3892/ol.2017.5744
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Abstract

The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti‑proliferative effect of stevioside on human colon cancer HT‑29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK signaling pathways in HT‑29 cells was explored. Stevioside was observed to significantly inhibit cancer cell growth at a dose of 5 µM at 48 and 72 h. A dose‑dependent increase in the apoptosis rate was observed with cell cycle arrest at G2/M phase. In addition, caspase-9 and caspase-3 activity also increased. An increase in reactive oxygen species (ROS) production and a decrease in the mitochondrial membrane potential indicated that the mitochondrial‑mediated intrinsic pathway is responsible for apoptotic activity. These results were additionally verified by the elevated expression level of phosphorylated p38 and extracellular signal‑regulated kinase mitogen‑activated protein kinases (MAPKs). Additionally, by inhibiting ROS production and MAPK activation, the antiproliferative effect of stevioside was suppressed, confirming the hypothesis that ROS and MAPK proteins induce apoptosis in human colon cancer HT-29 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Ren HP, Yin XY, Yu HY and Xiao HF: Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis. Oncol Lett 13: 2337-2343, 2017.
APA
Ren, H., Yin, X., Yu, H., & Xiao, H. (2017). Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis. Oncology Letters, 13, 2337-2343. https://doi.org/10.3892/ol.2017.5744
MLA
Ren, H., Yin, X., Yu, H., Xiao, H."Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis". Oncology Letters 13.4 (2017): 2337-2343.
Chicago
Ren, H., Yin, X., Yu, H., Xiao, H."Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis". Oncology Letters 13, no. 4 (2017): 2337-2343. https://doi.org/10.3892/ol.2017.5744
Copy and paste a formatted citation
x
Spandidos Publications style
Ren HP, Yin XY, Yu HY and Xiao HF: Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis. Oncol Lett 13: 2337-2343, 2017.
APA
Ren, H., Yin, X., Yu, H., & Xiao, H. (2017). Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis. Oncology Letters, 13, 2337-2343. https://doi.org/10.3892/ol.2017.5744
MLA
Ren, H., Yin, X., Yu, H., Xiao, H."Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis". Oncology Letters 13.4 (2017): 2337-2343.
Chicago
Ren, H., Yin, X., Yu, H., Xiao, H."Stevioside induced cytotoxicity in colon cancer cells via reactive oxygen species and mitogen-activated protein kinase signaling pathways-mediated apoptosis". Oncology Letters 13, no. 4 (2017): 2337-2343. https://doi.org/10.3892/ol.2017.5744
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