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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles

  • Authors:
    • Zoya Cohen
    • Yair Maimon
    • Noah Samuels
    • Raanan Berger
  • View Affiliations / Copyright

    Affiliations: Tal Center for Integrative Oncology, Institute of Oncology, Sheba Medical Center, 52621 Ramat Gan, Israel, Institute of Oncology, Sheba Medical Center, 52621 Ramat Gan, Israel
    Copyright: © Cohen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2642-2648
    |
    Published online on: February 17, 2017
       https://doi.org/10.3892/ol.2017.5747
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Abstract

Numerous botanicals have been shown to exhibit in vitro and in vivo anticancer activity, some of which is the result of the induction of reactive oxygen species (ROS) in cancer cells with a high ROS content. The present study compared sensitivities to a series of botanicals among cancer cell lines, using an XTT viability test, in order to create a specific cancer‑herb profile. Of the 27 botanicals screened, 10 exhibited a cytotoxic effect, 7 of which were ROS-mediated. The sensitivity profiles of the ROS‑inducing botanicals in 10 cancer cell lines were similar, unlike 3 cytotoxic ROS‑independent botanicals that displayed divergent botanical‑specific profiles. The correlation between sensitivity profiles of ROS‑inducing botanicals suggests a common mechanism of action, in contrast to the varied mechanism of ROS‑independent botanicals. This implies that the investigation of the anticancer activity of botanicals should start with the examination of ROS‑mediated activity. Further investigation of ROS sensitivity among various tumor types is required in order to guide research into developing evidence‑based guidelines in the use of botanicals for cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Cohen Z, Maimon Y, Samuels N and Berger R: Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles. Oncol Lett 13: 2642-2648, 2017.
APA
Cohen, Z., Maimon, Y., Samuels, N., & Berger, R. (2017). Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles. Oncology Letters, 13, 2642-2648. https://doi.org/10.3892/ol.2017.5747
MLA
Cohen, Z., Maimon, Y., Samuels, N., Berger, R."Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles". Oncology Letters 13.4 (2017): 2642-2648.
Chicago
Cohen, Z., Maimon, Y., Samuels, N., Berger, R."Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles". Oncology Letters 13, no. 4 (2017): 2642-2648. https://doi.org/10.3892/ol.2017.5747
Copy and paste a formatted citation
x
Spandidos Publications style
Cohen Z, Maimon Y, Samuels N and Berger R: Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles. Oncol Lett 13: 2642-2648, 2017.
APA
Cohen, Z., Maimon, Y., Samuels, N., & Berger, R. (2017). Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles. Oncology Letters, 13, 2642-2648. https://doi.org/10.3892/ol.2017.5747
MLA
Cohen, Z., Maimon, Y., Samuels, N., Berger, R."Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles". Oncology Letters 13.4 (2017): 2642-2648.
Chicago
Cohen, Z., Maimon, Y., Samuels, N., Berger, R."Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles". Oncology Letters 13, no. 4 (2017): 2642-2648. https://doi.org/10.3892/ol.2017.5747
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