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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin

  • Authors:
    • Yanqing Wu
    • Yinghua Zhu
    • Shunrong Li
    • Minhua Zeng
    • Junjun Chu
    • Pengnan Hu
    • Jingjing Li
    • Qiannan Guo
    • Xiao‑Bin Lv
    • Guofu Huang

  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510700, P.R. China, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat‑Sen Memorial Hospital affiliated to Sun Yat‑Sen University, Guangzhou, Guangdong 51012, P.R. China, Nanchang Key Laboratory of Cancer Pathogenesis and Translational Research, Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, P.R. China, Department of Ophthalmology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330008, P.R. China
  • Pages: 2805-2810
    |
    Published online on: February 22, 2017
       https://doi.org/10.3892/ol.2017.5758
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Abstract

Terrein is a bioactive fungal metabolite isolated from Aspergillus terreus. Besides being a melanogenesis inhibitor, previous studies have revealed that terrein has antiproliferative effects on a number of types of cancer tumors. In the present study, the inhibitory effect of terrein on esophageal cancer was evaluated and the possible underlying mechanisms were investigated. The results revealed that terrein inhibited the proliferation of Eca109 esophageal cancer cells in a dose‑ and time‑dependent manner. Mechanistically, terrein treatment led to the G2/M phase arrest of Eca109 cells by indirectly regulating cyclin B1 and phosphorylating the cell division cycle protein 2 genes. Notably, terrein exhibited a synergistic effect on Eca109 cells when combined with cisplatin, which is a commonly used chemotherapeutic drug. Taken together, these findings indicate that terrein suppresses the proliferation of esophageal cancer cells, and may prove to be a novel therapeutic approach for the treatment of esophageal cancer via inhibiting the proliferation of cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Zhu Y, Li S, Zeng M, Chu J, Hu P, Li J, Guo Q, Lv XB, Huang G, Huang G, et al: Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin. Oncol Lett 13: 2805-2810, 2017.
APA
Wu, Y., Zhu, Y., Li, S., Zeng, M., Chu, J., Hu, P. ... Huang, G. (2017). Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin. Oncology Letters, 13, 2805-2810. https://doi.org/10.3892/ol.2017.5758
MLA
Wu, Y., Zhu, Y., Li, S., Zeng, M., Chu, J., Hu, P., Li, J., Guo, Q., Lv, X., Huang, G."Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin". Oncology Letters 13.4 (2017): 2805-2810.
Chicago
Wu, Y., Zhu, Y., Li, S., Zeng, M., Chu, J., Hu, P., Li, J., Guo, Q., Lv, X., Huang, G."Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin". Oncology Letters 13, no. 4 (2017): 2805-2810. https://doi.org/10.3892/ol.2017.5758
Copy and paste a formatted citation
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Spandidos Publications style
Wu Y, Zhu Y, Li S, Zeng M, Chu J, Hu P, Li J, Guo Q, Lv XB, Huang G, Huang G, et al: Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin. Oncol Lett 13: 2805-2810, 2017.
APA
Wu, Y., Zhu, Y., Li, S., Zeng, M., Chu, J., Hu, P. ... Huang, G. (2017). Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin. Oncology Letters, 13, 2805-2810. https://doi.org/10.3892/ol.2017.5758
MLA
Wu, Y., Zhu, Y., Li, S., Zeng, M., Chu, J., Hu, P., Li, J., Guo, Q., Lv, X., Huang, G."Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin". Oncology Letters 13.4 (2017): 2805-2810.
Chicago
Wu, Y., Zhu, Y., Li, S., Zeng, M., Chu, J., Hu, P., Li, J., Guo, Q., Lv, X., Huang, G."Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin". Oncology Letters 13, no. 4 (2017): 2805-2810. https://doi.org/10.3892/ol.2017.5758
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