Open Access

MicroRNA‑130b promotes cell migration and invasion by inhibiting peroxisome proliferator‑activated receptor‑γ in human glioma

  • Authors:
    • Peidong Li
    • Xinjun Wang
    • Qiao Shan
    • Yuehui Wu
    • Zhen Wang
  • View Affiliations

  • Published online on: February 22, 2017     https://doi.org/10.3892/ol.2017.5760
  • Pages: 2615-2622
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioma is the most common and aggressive type of primary brain tumor. MicroRNA (miR)‑130b functions as a tumor‑associated miR. The dysregulation of miR‑130b is involved in numerous biological characteristics and properties of certain types of cancer. The present study revealed the function and possible molecular mechanism of miR‑130b in glioma cells, reporting that the level of miR‑130b was markedly higher, increasing progressively as the histologic grade of the glioma increased, compared with the level in normal tissues. Additionally, the present study demonstrated that patients with high miR‑130b expression exhibited a poor 3‑year survival rate and miR‑130b was an independent factor for predicting the prognosis of patients with glioma. The downregulation of miR‑130b reduced invasion and migration in U373 and U87 cells. Furthermore, the downregulation of miR‑130b increased peroxisome proliferator‑activated receptor‑γ (PPARγ) expression and inhibited epithelial‑mesenchymal transition (EMT) in glioma cells. The present study identified PPARγ as a direct target of miR‑130b in glioma in vitro. Furthermore, PPARγ knockdown was revealed to reduce the effect on EMT caused by the downregulation of miR‑130b in U87 cells. The present study demonstrated that miR‑130b promotes glioma proliferation, migration and invasion by suppressing PPARγ and subsequently inducing EMT.

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April 2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Li, P., Wang, X., Shan, Q., Wu, Y., & Wang, Z. (2017). MicroRNA‑130b promotes cell migration and invasion by inhibiting peroxisome proliferator‑activated receptor‑γ in human glioma. Oncology Letters, 13, 2615-2622. https://doi.org/10.3892/ol.2017.5760
MLA
Li, P., Wang, X., Shan, Q., Wu, Y., Wang, Z."MicroRNA‑130b promotes cell migration and invasion by inhibiting peroxisome proliferator‑activated receptor‑γ in human glioma". Oncology Letters 13.4 (2017): 2615-2622.
Chicago
Li, P., Wang, X., Shan, Q., Wu, Y., Wang, Z."MicroRNA‑130b promotes cell migration and invasion by inhibiting peroxisome proliferator‑activated receptor‑γ in human glioma". Oncology Letters 13, no. 4 (2017): 2615-2622. https://doi.org/10.3892/ol.2017.5760