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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Targeting assay of a fusion protein applied in enzyme prodrug therapy

  • Authors:
    • Hao Wang
    • Jin‑Jian Liu
    • Xiao‑Liang Zhou

  • View Affiliations / Copyright

    Affiliations: Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2698-2702
    |
    Published online on: February 22, 2017
       https://doi.org/10.3892/ol.2017.5768
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Abstract

Tumor growth and metastasis are dependent on angiogenesis. The overexpression of integrin αvβ3 on angiogenic vessels and on numerous malignant human tumor cells suggests that these labeled ligands of integrin are potentially suitable for molecular imaging and in targeted therapy of tumors. In previous studies, we added a β‑lactamase variant with reduced immunogenicity to the cyclic peptide RGD4C, resulting in the fusion protein RGD4CβL, which is suitable for use in targeted enzyme prodrug therapy (TEPT), a promising treatment for tumors. The targeting of the aforementioned fusion protein serves an important role in TEPT. In the present study, RGD4CβL was labeled with 125I and the targeting effect on integrin‑positive tumors was evaluated. The results demonstrated that the 125I‑RGD4CβL protein exhibited high levels of accumulation at the tumor site and rapid renal clearance, which revealed the potency and efficiency of RGD4CβL in TEPT.

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Liu JJ and Zhou XL: Targeting assay of a fusion protein applied in enzyme prodrug therapy. Oncol Lett 13: 2698-2702, 2017.
APA
Wang, H., Liu, J., & Zhou, X. (2017). Targeting assay of a fusion protein applied in enzyme prodrug therapy. Oncology Letters, 13, 2698-2702. https://doi.org/10.3892/ol.2017.5768
MLA
Wang, H., Liu, J., Zhou, X."Targeting assay of a fusion protein applied in enzyme prodrug therapy". Oncology Letters 13.4 (2017): 2698-2702.
Chicago
Wang, H., Liu, J., Zhou, X."Targeting assay of a fusion protein applied in enzyme prodrug therapy". Oncology Letters 13, no. 4 (2017): 2698-2702. https://doi.org/10.3892/ol.2017.5768
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Liu JJ and Zhou XL: Targeting assay of a fusion protein applied in enzyme prodrug therapy. Oncol Lett 13: 2698-2702, 2017.
APA
Wang, H., Liu, J., & Zhou, X. (2017). Targeting assay of a fusion protein applied in enzyme prodrug therapy. Oncology Letters, 13, 2698-2702. https://doi.org/10.3892/ol.2017.5768
MLA
Wang, H., Liu, J., Zhou, X."Targeting assay of a fusion protein applied in enzyme prodrug therapy". Oncology Letters 13.4 (2017): 2698-2702.
Chicago
Wang, H., Liu, J., Zhou, X."Targeting assay of a fusion protein applied in enzyme prodrug therapy". Oncology Letters 13, no. 4 (2017): 2698-2702. https://doi.org/10.3892/ol.2017.5768
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