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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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Article Open Access

Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells

  • Authors:
    • Kwang Il Park
    • Hyeonsoo Park
    • Arulkumar Nagappan
    • Gyeong Eun Hong
    • Silvia Yumnam
    • Ho Jeong Lee
    • Eun Hee Kim
    • Won Sup Lee
    • Sung Chul Shin
    • Jin A Kim
    • Sang Joon Lee
    • Jin Yeul Ma
    • Taesun Min
    • Jeong Doo Heo
    • Gon Sup Kim

  • View Affiliations / Copyright

    Affiliations: Korean Medicine (KM)‑Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu, North Gyeongsang 41062, Republic of Korea, Daegu‑Gyeongbuk Medical Innovation Foundation (DGMIF), Laboratory Animal Center, Daegu, North Gyeongsang 701‑310, Republic of Korea, Research Institute of Life Science and College of Veterinary Medicine, Gyeongsang National University, Jinju, South Gyeongsang 660‑701, Republic of Korea, Department of Nursing Science, International University of Korea, Jinju, South Gyeongsang 660‑759, Republic of Korea, Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Gyeongnam Regional Cancer Center, Gyeongsang National University Hospital, Jinju, South Gyeongsang 660‑702, Republic of Korea, Department of Chemistry, Research Institute of Life Science, Gyeongsang National University, Jinju, South Gyeongsang 660‑701, Republic of Korea, Department of Physical Therapy, International University of Korea, Jinju, South Gyeongsang 660‑759, Republic of Korea , Gyeongnam Department of Environment Toxicology and Chemistry, Toxicity Screening Research Center, Korea Institute of Toxicology, Jinju, South Gyeongsang 52834, Republic of Korea, Department of Animal Biotechnology, Jeju National University, Jeju-do 690-756, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2521-2530
    |
    Published online on: February 23, 2017
       https://doi.org/10.3892/ol.2017.5771
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Abstract

Lonicera japonica Thunb. (L. japonica T.) has historically been used in Korean herbal medicine due to its anticancer and protective effects on the respiratory system. In the present study, the polyphenolic compounds in L. japonica T. were investigated using high-performance liquid chromatography coupled with tandem mass spectrometry, and its anticancer effects on A549 non‑small‑cell lung cancer cells were studied. Polyphenolic compounds potentially inhibit A549 cells in a dose-dependent manner. Flow cytometry and western blot analysis demonstrated that polyphenolic compounds induce apoptosis by regulating the protein expression levels of caspases, poly‑(ADP‑ribose) polymerase and the B‑cell lymphoma‑2‑associated X-protein/B‑cell lymphoma‑extra large ratio. Furthermore, polyphenolic compounds inhibited mitochondrial membrane potential activity. Caspase‑3 activity was increased in a dose‑dependent manner and polyphenolic compounds inhibited the activation of protein kinase B by dephosphorylation. These results suggest that polyphenolic compounds in A549 cells indicate the anticancer activity through the induction of apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Park KI, Park H, Nagappan A, Hong GE, Yumnam S, Lee HJ, Kim EH, Lee WS, Shin SC, Kim JA, Kim JA, et al: Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells. Oncol Lett 13: 2521-2530, 2017.
APA
Park, K.I., Park, H., Nagappan, A., Hong, G.E., Yumnam, S., Lee, H.J. ... Kim, G.S. (2017). Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells. Oncology Letters, 13, 2521-2530. https://doi.org/10.3892/ol.2017.5771
MLA
Park, K. I., Park, H., Nagappan, A., Hong, G. E., Yumnam, S., Lee, H. J., Kim, E. H., Lee, W. S., Shin, S. C., Kim, J. A., Lee, S. J., Ma, J. Y., Min, T., Heo, J. D., Kim, G. S."Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells". Oncology Letters 13.4 (2017): 2521-2530.
Chicago
Park, K. I., Park, H., Nagappan, A., Hong, G. E., Yumnam, S., Lee, H. J., Kim, E. H., Lee, W. S., Shin, S. C., Kim, J. A., Lee, S. J., Ma, J. Y., Min, T., Heo, J. D., Kim, G. S."Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells". Oncology Letters 13, no. 4 (2017): 2521-2530. https://doi.org/10.3892/ol.2017.5771
Copy and paste a formatted citation
x
Spandidos Publications style
Park KI, Park H, Nagappan A, Hong GE, Yumnam S, Lee HJ, Kim EH, Lee WS, Shin SC, Kim JA, Kim JA, et al: Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells. Oncol Lett 13: 2521-2530, 2017.
APA
Park, K.I., Park, H., Nagappan, A., Hong, G.E., Yumnam, S., Lee, H.J. ... Kim, G.S. (2017). Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells. Oncology Letters, 13, 2521-2530. https://doi.org/10.3892/ol.2017.5771
MLA
Park, K. I., Park, H., Nagappan, A., Hong, G. E., Yumnam, S., Lee, H. J., Kim, E. H., Lee, W. S., Shin, S. C., Kim, J. A., Lee, S. J., Ma, J. Y., Min, T., Heo, J. D., Kim, G. S."Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells". Oncology Letters 13.4 (2017): 2521-2530.
Chicago
Park, K. I., Park, H., Nagappan, A., Hong, G. E., Yumnam, S., Lee, H. J., Kim, E. H., Lee, W. S., Shin, S. C., Kim, J. A., Lee, S. J., Ma, J. Y., Min, T., Heo, J. D., Kim, G. S."Polyphenolic compounds from Korean Lonicera japonica Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells". Oncology Letters 13, no. 4 (2017): 2521-2530. https://doi.org/10.3892/ol.2017.5771
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