Open Access

WT1-associated protein is a novel prognostic factor in pancreatic ductal adenocarcinoma

  • Authors:
    • Bing‑Qi Li
    • Shuai Huang
    • Qian‑Qian Shao
    • Jian Sun
    • Li Zhou
    • Lei You
    • Tai‑Ping Zhang
    • Quan Liao
    • Jun‑Chao Guo
    • Yu‑Pei Zhao
  • View Affiliations

  • Published online on: February 28, 2017     https://doi.org/10.3892/ol.2017.5784
  • Pages: 2531-2538
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although Wilms tumor 1 (WT1)-associated protein (WTAP) was initially found to be a specific WT1‑binding protein, it has increasingly attracted attention because of its oncogenic role in various types of malignancies, including cholangiocarcinoma, glioblastoma and acute myeloid leukemia. However, the clinical impact of WTAP on pancreatic ductal adenocarcinoma (PDAC) is still unknown. A total of 145 patients who underwent surgical treatment from 2004 to 2008 were enrolled in the present study. The cytoplasmic and nuclear expression of WTAP in tumor and adjacent normal tissues was examined by immunohistochemical analysis in order to investigate the relationship between WTAP and the clinicopathological factors and prognosis of patients with PDAC. The nuclear and cytoplasmic expression of WTAP in tumor tissues was significantly higher compared with non‑tumor tissues (P<0.001). High expression of WTAP in the nucleus was significantly associated with gender (P=0.010) and tumor stage (P=0.020), while high expression of WTAP in the cytoplasm was significantly associated with gender (P=0.018), histological grade (P=0.047) and perineural invasion (P=0.028). In addition, a univariate analysis revealed that high nuclear expression of WTAP in tumor tissues was significantly associated with poor overall survival (P<0.001), as well as several clinicopathological variables, including gender and N stage. In a multivariate Cox regression analysis, nuclear WTAP expression was identified as an independent prognostic indicator for PDAC (relative risk, 1.855; 95% confidence interval, 1.033‑3.333; P=0.039). The results of the present study indicated that high nuclear expression of WTAP is a valuable molecular biomarker of a poor prognosis among patients with PDAC.

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April-2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li BQ, Huang S, Shao QQ, Sun J, Zhou L, You L, Zhang TP, Liao Q, Guo JC, Zhao YP, Zhao YP, et al: WT1-associated protein is a novel prognostic factor in pancreatic ductal adenocarcinoma. Oncol Lett 13: 2531-2538, 2017.
APA
Li, B., Huang, S., Shao, Q., Sun, J., Zhou, L., You, L. ... Zhao, Y. (2017). WT1-associated protein is a novel prognostic factor in pancreatic ductal adenocarcinoma. Oncology Letters, 13, 2531-2538. https://doi.org/10.3892/ol.2017.5784
MLA
Li, B., Huang, S., Shao, Q., Sun, J., Zhou, L., You, L., Zhang, T., Liao, Q., Guo, J., Zhao, Y."WT1-associated protein is a novel prognostic factor in pancreatic ductal adenocarcinoma". Oncology Letters 13.4 (2017): 2531-2538.
Chicago
Li, B., Huang, S., Shao, Q., Sun, J., Zhou, L., You, L., Zhang, T., Liao, Q., Guo, J., Zhao, Y."WT1-associated protein is a novel prognostic factor in pancreatic ductal adenocarcinoma". Oncology Letters 13, no. 4 (2017): 2531-2538. https://doi.org/10.3892/ol.2017.5784