Open Access

Lentivirus-mediated RNA interference of tripartite motif 68 inhibits the proliferation of colorectal cancer cell lines SW1116 and HCT116 in vitro

  • Authors:
    • Zhen Tan
    • Xiaoshuang Liu
    • Enda Yu
    • Hantao Wang
    • Lijun Tang
    • Hao Wang
    • Chuangang Fu
  • View Affiliations

  • Published online on: February 28, 2017     https://doi.org/10.3892/ol.2017.5787
  • Pages: 2649-2655
  • Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer is one of the most common types of cancer worldwide. Previous studies have revealed that certain members of tripartite motif (TRIM) proteins are involved in carcin ogenesis regulation, but little is known about the function of TRIM68 in human colorectal cancer. To investigate the role of TRIM68 in colorectal cancer SW1116 and HCT116 cell lines, the present study conducted lentivirus‑mediated knockdown against TRIM68 and demonstrated that depletion of TRIM68 notably inhibits colorectal cancer cell proliferation and colony formation ability. Cell cycle arrest in the G0/G1 phase and cycle accumulation in sub‑G1 phase provided evidence that TRIM68 may participate in the regulation of colorectal cancer tumorigenesis. The results revealed the significant role of TRIM68 in regulating colorectal cancer cell mitosis and indicated that TRIM68 may be a promising therapeutic target.

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April-2017
Volume 13 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tan Z, Liu X, Yu E, Wang H, Tang L, Wang H and Fu C: Lentivirus-mediated RNA interference of tripartite motif 68 inhibits the proliferation of colorectal cancer cell lines SW1116 and HCT116 in vitro. Oncol Lett 13: 2649-2655, 2017
APA
Tan, Z., Liu, X., Yu, E., Wang, H., Tang, L., Wang, H., & Fu, C. (2017). Lentivirus-mediated RNA interference of tripartite motif 68 inhibits the proliferation of colorectal cancer cell lines SW1116 and HCT116 in vitro. Oncology Letters, 13, 2649-2655. https://doi.org/10.3892/ol.2017.5787
MLA
Tan, Z., Liu, X., Yu, E., Wang, H., Tang, L., Wang, H., Fu, C."Lentivirus-mediated RNA interference of tripartite motif 68 inhibits the proliferation of colorectal cancer cell lines SW1116 and HCT116 in vitro". Oncology Letters 13.4 (2017): 2649-2655.
Chicago
Tan, Z., Liu, X., Yu, E., Wang, H., Tang, L., Wang, H., Fu, C."Lentivirus-mediated RNA interference of tripartite motif 68 inhibits the proliferation of colorectal cancer cell lines SW1116 and HCT116 in vitro". Oncology Letters 13, no. 4 (2017): 2649-2655. https://doi.org/10.3892/ol.2017.5787