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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2017 Volume 13 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis

  • Authors:
    • Christine Dinkic
    • Friederike Jahn
    • Marek Zygmunt
    • Florian Schuetz
    • Joachim Rom
    • Christof Sohn
    • Herbert Fluhr

  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Heidelberg University Hospital, D‑69120 Heidelberg, Germany, Department of Gynecology and Obstetrics, Greifswald University Hospital, D‑17475 Greifswald, Germany
  • Pages: 2847-2851
    |
    Published online on: March 1, 2017
       https://doi.org/10.3892/ol.2017.5795
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Abstract

PARP inhibitors are used in the treatment of gynecological malignancies and it has been demonstrated in preclinical studies that PARP inhibition sensitizes cancer cells to cytotoxic agents. In the present study, PARP expression was detected in different endometrial cancer cell lines by western blot analysis, and PARP activity was measured using an enzymatic assay. In addition, the endometrial cancer cell lines were treated with paclitaxel or carboplatin in combination with the PARP inhibitor PJ34 prior to a cell viability assay and apoptotic nuclei measurement. PARP protein was detected in all four cell lines examined, although its activity varied between the cell lines. Treatment with PJ34 in combination with paclitaxel decreased endometrial cancer cell viability compared with treatment with paclitaxel alone. These results indicate that the inhibition of PARP with PJ34 sensitizes endometrial cancer cells to cytotoxic treatment with paclitaxel.

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Copy and paste a formatted citation
Spandidos Publications style
Dinkic C, Jahn F, Zygmunt M, Schuetz F, Rom J, Sohn C and Fluhr H: PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis. Oncol Lett 13: 2847-2851, 2017.
APA
Dinkic, C., Jahn, F., Zygmunt, M., Schuetz, F., Rom, J., Sohn, C., & Fluhr, H. (2017). PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis. Oncology Letters, 13, 2847-2851. https://doi.org/10.3892/ol.2017.5795
MLA
Dinkic, C., Jahn, F., Zygmunt, M., Schuetz, F., Rom, J., Sohn, C., Fluhr, H."PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis". Oncology Letters 13.4 (2017): 2847-2851.
Chicago
Dinkic, C., Jahn, F., Zygmunt, M., Schuetz, F., Rom, J., Sohn, C., Fluhr, H."PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis". Oncology Letters 13, no. 4 (2017): 2847-2851. https://doi.org/10.3892/ol.2017.5795
Copy and paste a formatted citation
x
Spandidos Publications style
Dinkic C, Jahn F, Zygmunt M, Schuetz F, Rom J, Sohn C and Fluhr H: PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis. Oncol Lett 13: 2847-2851, 2017.
APA
Dinkic, C., Jahn, F., Zygmunt, M., Schuetz, F., Rom, J., Sohn, C., & Fluhr, H. (2017). PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis. Oncology Letters, 13, 2847-2851. https://doi.org/10.3892/ol.2017.5795
MLA
Dinkic, C., Jahn, F., Zygmunt, M., Schuetz, F., Rom, J., Sohn, C., Fluhr, H."PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis". Oncology Letters 13.4 (2017): 2847-2851.
Chicago
Dinkic, C., Jahn, F., Zygmunt, M., Schuetz, F., Rom, J., Sohn, C., Fluhr, H."PARP inhibition sensitizes endometrial cancer cells to paclitaxel-induced apoptosis". Oncology Letters 13, no. 4 (2017): 2847-2851. https://doi.org/10.3892/ol.2017.5795
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