Distant recurrence risk following early ipsilateral breast tumor recurrence

Ishitobi,Makoto; Okuno,Jun; Kittaka,Nobuyoshi; Nakayama,Takahiro; Koyama,Hiroki; Tamaki,Yasuhiro

doi:10.3892/ol.2017.5797

Distant recurrence risk following early ipsilateral breast tumor recurrence

Authors:
- Makoto Ishitobi
- Jun Okuno
- Nobuyoshi Kittaka
- Takahiro Nakayama
- Hiroki Koyama
- Yasuhiro Tamaki
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Affiliations: Department of Breast and Endocrine Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari‑ku, Osaka 537‑8511, Japan
Published online on: March 3, 2017 https://doi.org/10.3892/ol.2017.5797
Pages: 2886-2890
Copyright: © Ishitobi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

At present, the risk factors for distant recurrence among patients with early ipsilateral breast tumor recurrence (IBTR) require further investigation. Early IBTR is defined as occurring within 3 years following the initial surgery. In the current study, 40 patients with early IBTR were examined to determine the risk factors for distant recurrence. A node-positive status at the time of primary surgery and the administration of adjuvant chemotherapy following the primary surgery were significantly correlated with poorer distant disease‑free survival (P=0.001 and P=0.002, respectively). Multivariate analyses revealed that the nodal status at the time of primary surgery was an independent predictive factor for distant recurrence (P=0.050). Therefore, the results of the current study revealed that the nodal status at the time of primary surgery was an independent predictive factor for distant recurrence among patients with early IBTR.

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