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Article

Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer

  • Authors:
    • Bin Hu
    • Qing Wang
    • Yingying Shi
    • Shufang Lu
    • Hongjie Qu
    • Lu Wang
    • Jinquan Cui
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450014, P.R. China, Department of Gynecology, The First People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China
  • Pages: 3219-3224
    |
    Published online on: March 6, 2017
       https://doi.org/10.3892/ol.2017.5804
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Abstract

The aim of this study was to explore the expression of heparanase (HPA) in metastatic lymph nodes (LNs) of cervical cancer and to evaluate HPA as a marker of micro-metastasis of LNs. Immunohistochemistry was performed to detect the expression of HPA in 53 cases with metastasis of LNs (group A) and 49 cases without (group B). Scoring was determined based on the intensity of immuno­staining and the size of the staining area. Three points or higher score was considered as positive. Among all cases, the positive rate of HPA was 76.5% in primary lesions and 84.9% in both primary lesions and metastatic LNs in group A. In group B, the rates were 67.3% in primary lesions and 8.2% in metastatic LNs. The expression of HPA in group A was significantly higher than that in group B (P<0.05). Compared with stage IA‑IB and well‑differentiated and non‑metastatic LNs, the LNs of stage IIA and moderately/poorly differentiated and metastatic LNs expressed higher HPA (P<0.05). The overall 5‑year survival rate was 73.3% and the median overall survival time (MOS) was 49.0 months. The MOS of the two groups was 36.0 and 58.5 months, respectively (P=0.023); the MOS of patients with positive HPA expression was distinctly lower than that of negative patients (P=0.040). Clinical staging, degree of differentiation, lymph node metastasis and expression of HPA notably affected patient prognosis; lymph node metastasis and expression of HPA were independent risk factors affecting patient prognosis (P<0.05). Our study demonstrated that high‑level expression of HPA in cervical cancer was involved in LN metastasis, further impacting on patients' long‑term survival. The clinical value of HPA requires further in-depth study.
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Copy and paste a formatted citation
Spandidos Publications style
Hu B, Wang Q, Shi Y, Lu S, Qu H, Wang L and Cui J: Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer. Oncol Lett 13: 3219-3224, 2017.
APA
Hu, B., Wang, Q., Shi, Y., Lu, S., Qu, H., Wang, L., & Cui, J. (2017). Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer. Oncology Letters, 13, 3219-3224. https://doi.org/10.3892/ol.2017.5804
MLA
Hu, B., Wang, Q., Shi, Y., Lu, S., Qu, H., Wang, L., Cui, J."Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer". Oncology Letters 13.5 (2017): 3219-3224.
Chicago
Hu, B., Wang, Q., Shi, Y., Lu, S., Qu, H., Wang, L., Cui, J."Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer". Oncology Letters 13, no. 5 (2017): 3219-3224. https://doi.org/10.3892/ol.2017.5804
Copy and paste a formatted citation
x
Spandidos Publications style
Hu B, Wang Q, Shi Y, Lu S, Qu H, Wang L and Cui J: Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer. Oncol Lett 13: 3219-3224, 2017.
APA
Hu, B., Wang, Q., Shi, Y., Lu, S., Qu, H., Wang, L., & Cui, J. (2017). Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer. Oncology Letters, 13, 3219-3224. https://doi.org/10.3892/ol.2017.5804
MLA
Hu, B., Wang, Q., Shi, Y., Lu, S., Qu, H., Wang, L., Cui, J."Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer". Oncology Letters 13.5 (2017): 3219-3224.
Chicago
Hu, B., Wang, Q., Shi, Y., Lu, S., Qu, H., Wang, L., Cui, J."Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer". Oncology Letters 13, no. 5 (2017): 3219-3224. https://doi.org/10.3892/ol.2017.5804
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