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Article

Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma

  • Authors:
    • Katsuhiro Okuda
    • Risa Oda
    • Ayumi Suzuki
    • Tsutomu Tatematsu
    • Hiroshi Haneda
    • Satoru Moriyama
    • Motoki Yano
    • Ryoichi Nakanishi
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467‑8601, Japan
  • Pages: 3144-3150
    |
    Published online on: March 6, 2017
       https://doi.org/10.3892/ol.2017.5805
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Abstract

Thymic carcinoma is a rare mediastinum malignant tumor derived from thymic epithelial cells. With the exception of complete resection, an effective therapy has not been established to date for advanced or relapsed thymic carcinoma. The present study examined the protein expression of excision repair cross-complementation group 1 (ERCC1) and class Ⅲ β-tubulin (TUBB3), which are consider to be indicators of the anticancer activity of platinum‑based and taxane‑based chemotherapy, respectively. The expression of ERCC1 and TUBB3 proteins was examined in 40 thymic carcinoma patients who underwent either surgical resection or core‑needle biopsy. The present study investigated whether the expression of ERCC1 and TUBB3 proteins was associated with the overall survival and clinicopathological factors of thymic carcinoma patients. The expression of ERCC1 and TUBB3 proteins was also evaluated in 50 patients who underwent curative resection for non‑small cell lung cancer (NSCLC). The expression of ERCC1 and TUBB3 proteins was positive in 8 cases (20%) among the thymic carcinoma patients. ERCC1 was expressed in 21 cases (42%), while TUBB3 was expressed in 27 cases (54%), among the 50 NSCLC patients evaluated in the present study. Only complete resection was observed to be associated with a better prognosis than incomplete resection (P=0.0341). Other clinicopathological factors, including expression of ERCC1 and TUBB3 proteins, exhibited no effect on overall survival. The expression of ERCC1 and TUBB3 proteins in the thymic carcinoma cases was lower than that in the NSCLC cases. The present results suggest a possibility for better antitumor effects of platinum‑based and taxane-based chemotherapy on thymic carcinoma patients.
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Copy and paste a formatted citation
Spandidos Publications style
Okuda K, Oda R, Suzuki A, Tatematsu T, Haneda H, Moriyama S, Yano M and Nakanishi R: Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma. Oncol Lett 13: 3144-3150, 2017.
APA
Okuda, K., Oda, R., Suzuki, A., Tatematsu, T., Haneda, H., Moriyama, S. ... Nakanishi, R. (2017). Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma. Oncology Letters, 13, 3144-3150. https://doi.org/10.3892/ol.2017.5805
MLA
Okuda, K., Oda, R., Suzuki, A., Tatematsu, T., Haneda, H., Moriyama, S., Yano, M., Nakanishi, R."Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma". Oncology Letters 13.5 (2017): 3144-3150.
Chicago
Okuda, K., Oda, R., Suzuki, A., Tatematsu, T., Haneda, H., Moriyama, S., Yano, M., Nakanishi, R."Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma". Oncology Letters 13, no. 5 (2017): 3144-3150. https://doi.org/10.3892/ol.2017.5805
Copy and paste a formatted citation
x
Spandidos Publications style
Okuda K, Oda R, Suzuki A, Tatematsu T, Haneda H, Moriyama S, Yano M and Nakanishi R: Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma. Oncol Lett 13: 3144-3150, 2017.
APA
Okuda, K., Oda, R., Suzuki, A., Tatematsu, T., Haneda, H., Moriyama, S. ... Nakanishi, R. (2017). Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma. Oncology Letters, 13, 3144-3150. https://doi.org/10.3892/ol.2017.5805
MLA
Okuda, K., Oda, R., Suzuki, A., Tatematsu, T., Haneda, H., Moriyama, S., Yano, M., Nakanishi, R."Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma". Oncology Letters 13.5 (2017): 3144-3150.
Chicago
Okuda, K., Oda, R., Suzuki, A., Tatematsu, T., Haneda, H., Moriyama, S., Yano, M., Nakanishi, R."Expression of excision repair cross-complementation group 1 and class III β-tubulin in thymic carcinoma". Oncology Letters 13, no. 5 (2017): 3144-3150. https://doi.org/10.3892/ol.2017.5805
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