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Article

Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer

  • Authors:
    • Masahiro Ito
    • Kazuhiro Migita
    • Sohei Matsumoto
    • Kohei Wakatsuki
    • Tetsuya Tanaka
    • Tomohiro Kunishige
    • Hiroshi Nakade
    • Mitsuhiro Nakatani
    • Yoshiyuki Nakajima
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Nara Medical University, Kashihara, Nara 634‑8522, Japan
  • Pages: 3131-3138
    |
    Published online on: March 6, 2017
       https://doi.org/10.3892/ol.2017.5806
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Abstract

Tripartite motif protein (TRIM) 32 belongs to the TRIM family, which is composed of RING finger, B‑box and coiled‑coil domains. TRIM32 has been reported to function as an enzyme 3 ubiquitin ligase and is overexpressed in numerous types of cancer. The present study evaluated the clinical significance of TRIM32 expression levels in gastric cancer. The current study also investigated the TRIM32 expression levels in 142 patients with gastric cancer using immunohistochemistry and examined its clinical importance and potential as a prognostic marker. Furthermore, the function of TRIM32 was examined in vitro. High TRIM32 expression levels were detected in gastric cancer tissues. The postoperative overall and relapse-free survival rates were significantly reduced in patients with tumors with high levels of TRIM32 expression compared with those with tumors expressing low levels of TRIM32. Tumors expressing high levels of TRIM32 were associated with an increased risk of postoperative recurrence, particularly hematogenous recurrence. Multivariate analysis identified TRIM32 status as an independent prognostic factor. Furthermore, TRIM32 gene silencing induced apoptosis and inhibited the proliferation of gastric cancer cells in vitro. Therefore, TRIM32 expression levels may be of potential prognostic value in gastric cancer.
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1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Sun P, Xiang JB and Chen ZY: Meta-analysis of adjuvant chemotherapy after radical surgery for advanced gastric cancer. Br J Surg. 96:26–33. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Hershko A and Ciechanover A: The ubiquitin system. Annu Rev Biochem. 67:425–479. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Varshavsky A: The ubiquitin system, an immense realm. Annu Rev Biochem. 81:167–176. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Eldridge AG and O'Brien T: Therapeutic strategies within the ubiquitin proteasome system. Cell Death Differ. 17:4–13. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, et al: The tripartite motif family identifies cell compartments. EMBO J. 20:2140–2151. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Kakizuka A, Miller WH Jr, Umesono K, Warrell RP Jr, Frankel SR, Murty VV, Dmitrovsky E and Evans RM: Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell. 66:663–674. 1991. View Article : Google Scholar : PubMed/NCBI

8 

Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL and Barton MC: Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci USA. 106:11612–11616. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Sakuma M, Akahira J, Suzuki T, Inoue S, Ito K, Moriya T, Sasano H, Okamura K and Yaegashi N: Expression of estrogen-responsive finger protein (Efp) is associated with advanced disease in human epithelial ovarian cancer. Gynecol Oncol. 99:664–670. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Fridell RA, Harding LS, Bogerd HP and Cullen BR: Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins. Virology. 209:347–357. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Albor A, El-Hizawi S, Horn EJ, Laederich M, Frosk P, Wrogemann K and Kulesz-Martin M: The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB. J Biol Chem. 281:25850–25866. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Watanabe T, Imoto I, Kosugi Y, Ishiwata I, Inoue S, Takayama M, Sato A and Inazawa J: A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization. Gynecol Oncol. 81:172–177. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Horn EJ, Albor A, Liu Y, El-Hizawi S, Vanderbeek GE, Babcock M, Bowden GT, Hennings H, Lozano G, Weinberg WC and Kulesz-Martin M: RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties. Carcinogenesis. 25:157–167. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Kano S, Miyajima N, Fukuda S and Hatakeyama S: Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2. Cancer Res. 68:5572–5580. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Liu J, Zhang C, Wang XL, Ly P, Belyi V, Xu-Monette ZY, Young KH, Hu W and Feng Z: E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell Death Differ. 21:1792–1804. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Sobin L, Gospodarowicz M and Wittekind C: TNM classification of malignant tumours. 7th. New Jersey; Wiley-Blackwell; 2009

17 

Robertson JF, Nicholson RI, Bundred NJ, Anderson E, Rayter Z, Dowsett M, Fox JN, Gee JM, Webster A, Wakeling AE, et al: Comparison of the short-term biological effects of 7alpha- [9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer. Cancer Res. 61:6739–6746. 2001.PubMed/NCBI

18 

Ye Y, Li X, Yang J, Miao S, Wang S, Chen Y, Xia X, Wu X, Zhang J, Zhou Y, et al: MDM2 is a useful prognostic biomarker for resectable gastric cancer. Cancer Sci. 104:590–598. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Masuda TA, Inoue H, Sonoda H, Mine S, Yoshikawa Y, Nakayama K, Nakayama K and Mori M: Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: Modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. Cancer Res. 62:3819–3825. 2002.PubMed/NCBI

20 

Bai J, Zhou Y, Chen G, Zeng J, Ding J, Tan Y, Zhou J and Li G: Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer. Hum Pathol. 42:375–383. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Migita K, Takayama T, Matsumoto S, Wakatsuki K, Tanaka T, Ito M, Nishiwada S and Nakajima Y: Prognostic impact of RING box protein-1 (RBX1) expression in gastric cancer. Gastric Cancer. 17:601–609. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Sawada G, Ueo H, Matsumura T, Uchi R, Ishibashi M, Mima K, Kurashige J, Takahashi Y, Akiyoshi S, Sudo T, et al: Loss of COP1 expression determines poor prognosisin patients with gastric cancer. Oncol Rep. 30:1971–1975. 2013.PubMed/NCBI

23 

Gan L, Liu DB, Lu HF, Long GX, Mei Q, Hu GY, Qiu H and Hu GQ: Decreased expression of the carboxyl terminus of heat shock cognate 70 interacting protein in human gastric cancer and its clinical significance. Oncol Rep. 28:1392–1398. 2012.PubMed/NCBI

24 

Yokoe T, Toiyama Y, Okugawa Y, Tanaka K, Ohi M, Inoue Y, Mohri Y, Miki C and Kusunoki M: KAP1 is associated with peritoneal carcinomatosis in gastric cancer. Ann Surg Oncol. 17:821–828. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Kosaka Y, Inoue H, Ohmachi T, Yokoe T, Matsumoto T, Mimori K, Tanaka F, Watanabe M and Mori M: Tripartite motif-containing 29 (TRIM29) is a novel marker for lymph node metastasis in gastric cancer. Ann Surg Oncol. 14:2543–2549. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Huang Z, Zhang N, Zha L, Mao HC, Chen X, Xiang JF, Zhang H and Wang ZW: Aberrant expression of the autocrine motility factor receptor correlates with poor prognosis and promotes metastasis in gastric carcinoma. Asian Pac J Cancer Prev. 15:989–997. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, et al: Cancer proliferation gene discovery through functional genomics. Science. 319:620–624. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ito M, Migita K, Matsumoto S, Wakatsuki K, Tanaka T, Kunishige T, Nakade H, Nakatani M and Nakajima Y: Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer. Oncol Lett 13: 3131-3138, 2017.
APA
Ito, M., Migita, K., Matsumoto, S., Wakatsuki, K., Tanaka, T., Kunishige, T. ... Nakajima, Y. (2017). Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer. Oncology Letters, 13, 3131-3138. https://doi.org/10.3892/ol.2017.5806
MLA
Ito, M., Migita, K., Matsumoto, S., Wakatsuki, K., Tanaka, T., Kunishige, T., Nakade, H., Nakatani, M., Nakajima, Y."Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer". Oncology Letters 13.5 (2017): 3131-3138.
Chicago
Ito, M., Migita, K., Matsumoto, S., Wakatsuki, K., Tanaka, T., Kunishige, T., Nakade, H., Nakatani, M., Nakajima, Y."Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer". Oncology Letters 13, no. 5 (2017): 3131-3138. https://doi.org/10.3892/ol.2017.5806
Copy and paste a formatted citation
x
Spandidos Publications style
Ito M, Migita K, Matsumoto S, Wakatsuki K, Tanaka T, Kunishige T, Nakade H, Nakatani M and Nakajima Y: Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer. Oncol Lett 13: 3131-3138, 2017.
APA
Ito, M., Migita, K., Matsumoto, S., Wakatsuki, K., Tanaka, T., Kunishige, T. ... Nakajima, Y. (2017). Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer. Oncology Letters, 13, 3131-3138. https://doi.org/10.3892/ol.2017.5806
MLA
Ito, M., Migita, K., Matsumoto, S., Wakatsuki, K., Tanaka, T., Kunishige, T., Nakade, H., Nakatani, M., Nakajima, Y."Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer". Oncology Letters 13.5 (2017): 3131-3138.
Chicago
Ito, M., Migita, K., Matsumoto, S., Wakatsuki, K., Tanaka, T., Kunishige, T., Nakade, H., Nakatani, M., Nakajima, Y."Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer". Oncology Letters 13, no. 5 (2017): 3131-3138. https://doi.org/10.3892/ol.2017.5806
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