Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma

  • Authors:
    • Meiying Ji
    • Aihua Jin
    • Jie Sun
    • Xuelian Cui
    • Yang Yang
    • Liyan Chen
    • Zhenhua Lin
  • View Affiliations / Copyright

    Affiliations: Cancer Research Center and Department of Pathology, Yanbian University Medical College, Yanji, Jilin 133002, P.R. China, Department of Internal Medicine, Yanbian University Hospital, Yanji, Jilin 133000, P.R. China
    Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2996-3002
    |
    Published online on: March 7, 2017
       https://doi.org/10.3892/ol.2017.5821
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase 1 (NQO1) protects cells from oxidative damage. NQO1 has been reported to be upregulated in numerous solid tumors, suggesting a role in carcinogenesis and tumor progression. The present study attempted to investigate the clinical prognostic significance of NQO1 overexpression in pancreatic ductal adenocarcinoma (PDAC). A total of 181 tissue specimens were studied, including 126 PDAC and 55 normal pancreas specimens, which were selected for immunohistochemical staining of NQO1 protein. Immunofluorescence staining was additionally performed to identify the subcellular localization of NQO1 protein in pancreatic cancer BxPC‑3 cells. The association between NQO1 overexpression and the clinical features of PDAC were evaluated by χ2 and Fisher's exact test. Overall survival of PDAC patients was calculated using Kaplan‑Meier analysis. Univariate and multivariate analyses were performed using the Cox proportional hazards regression model. The NQO1 protein was mainly located in the cytoplasm and nucleus of BxPC‑3 cells. The strongly positive rate of NQO1 expression in PDAC (65.9%, 83/126) was increased compared with that in normal pancreatic tissues (10.9%, 6/55). The positive rate of NQO1 protein was associated with grading, lymph node stage and tumor‑node‑metastasis (TNM) stage. Additionally, multivariate analysis suggested that NQO1 was a significant independent prognostic factor along with TNM stage in PDAC. In conclusion, high expression of NQO1 appears to be associated with PDAC progression, and may be an independent prognostic biomarker in PDAC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Michl P and Gress TM: Current concepts and novel targets in advanced pancreatic cancer. Gut. 62:317–326. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Charpentier M and Martin S: Interplay of stem cell characteristics, EMT and microtentacles in circulating breast tumor cells. Cancers (Basel). 5:1545–1565. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Cuppone F, Bria E, Vaccaro V, Puglisi F, Fabi A, Sperduti I, Carlini P, Milella M, Nisticò C, Russillo M, et al: Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials. J Exp Clin Cancer Res. 30:542011. View Article : Google Scholar : PubMed/NCBI

5 

Rosvold EA, McGlynn KA, Lustbader ED and Buetow KH: Re: Detection of a point mutation in NQO1 (DT-diaphorase) in a patient with colon cancer. J Natl Cancer Inst. 87:1802–1803. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Schlager JJ and Powis G: Cytosolic NAD(P)H: (Quinone-acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol. Int J Cancer. 45:403–409. 1990. View Article : Google Scholar : PubMed/NCBI

7 

Buranrat B, Prawan A, Kukongviriyapan U, Kongpetch S and Kukongviriyapan V: Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells. World J Gastroenterol. 16:2362–2370. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Su XL, Yan MR and Yang L: Qimuge-Suyila: NQO1 C609T polymorphism correlated to colon cancer risk in farmers from western region of Inner Mongolia. Chin J Cancer Res. 24:317–322. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Siegel D, Franklin WA and Ross D: Immunohistochemical detection of NAD(P)H: Quinone oxidoreductase in human lung and lung tumors. Clin Cancer Res. 4:2065–2070. 1998.PubMed/NCBI

10 

Siegel D and Ross D: Immunodetection of NAD(P)H: Quinone oxidoreductase 1 (NQO1) in human tissues. Free Radic Biol Med. 29:246–253. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Sobin L, Gospodarowicz M and Wittekind C: TNM Classification of Malignant Tumours. 7th. Wiley Blackwell; Bognor Regis, UK: 2009

12 

Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: AJCC cancer staging manual. Springer; New York, NY: 2010

13 

Bosman F, Carneiro F, Hruban RH and Theise ND: Who classification of Tumours of the Digesitive System. IARC Press; Lyon: 2010

14 

Ernster L and Navazio F: Soluble diaphorase in animal tissues. Acta Chem Scand. 12:595–602. 1958. View Article : Google Scholar

15 

Ross D, Kepa JK, Winski SL, Beall HD, Anwar A and Siegel D: NAD(P)H: Quinone oxidoreductase 1 (NQO1): Chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact. 129:77–97. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Garate M, Wani AA and Li G: The NAD(P)H: Quinone oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells. Free Radic Biol Med. 48:1601–1609. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Iskander K, Li J, Han S, Zheng B and Jaiswal AK: NQO1 and NQO2 regulation of humoral immunity and autoimmunity. J Biol Chem. 281:30917–30924. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Siegel D, Kepa JK and Ross D: NAD(P)H: Quinone oxidoreductase 1 (NQO1) localizes to the mitotic spindle in human cells. PLoS One. 7:e448612012. View Article : Google Scholar : PubMed/NCBI

19 

Malkinson AM, Siegel D, Forrest GL, Gazdar AF, Oie HK, Chan DC, Bunn PA, Mabry M, Dykes DJ, Harrison SD, et al: Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin Cl. Cancer Res. 52:4752–4757. 1992.PubMed/NCBI

20 

Cheng Y, Li J, Martinka M and Li G: The expression of NAD(P)H: Quinone oxidoreductase 1 is increased along with NF-κB p105/p50 in human cutaneous melanomas. Oncol Rep. 23:973–979. 2010.PubMed/NCBI

21 

Li Z, Zhang Y, Jin T, Men J, Lin Z, Qi P, Piao Y and Yan G: NQO1 protein expression predicts poor prognosis of non-small cell lung cancers. BMC Cancer. 15:2072015. View Article : Google Scholar : PubMed/NCBI

22 

Cui X, Li L, Yan G, Meng K, Lin Z, Nan Y, Jin G and Li C: High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma. BMC cancer. 15:2442015. View Article : Google Scholar : PubMed/NCBI

23 

Lin L, Qin Y, Jin T, Liu S, Zhang S, Shen X and Lin Z: Significance of NQO1 overexpression for prognostic evaluation of gastric adenocarcinoma. Exp Mol Pathol. 96:200–205. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Mikami K, Naito M, Tomida A, Yamada M, Sirakusa T and Tsuruo T: DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines. Cancer Res. 56:2823–2826. 1996.PubMed/NCBI

25 

Buranrat B, Chau-In S, Prawan A, Puapairoj A, Zeekpudsa P and Kukongviriyapan V: NQO1 expression correlates with cholangiocarcinoma prognosis. Asian Pac J Cancer Prev. 13:(Suppl). S131–S136. 2012.

26 

Kuang HN, Weng TY, Liu YL, Lu KS and Chau YP: Sulidac compounds facilitate the cytotoxicity of β-lapachone by up-regulation of NAD(P)H quinone oxidoreductase in human lung cancer cells. PLoS One. 9:e881222014. View Article : Google Scholar : PubMed/NCBI

27 

Park EJ, Min KJ, Lee TJ, Yoo YH, Kim YS and Kwon TK: β-lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Kep1 cells. Cell Death Dis. 5:e12302014. View Article : Google Scholar : PubMed/NCBI

28 

Huang X, Dong Y, Bey EA, Kilgore JA, Bair JS, Li LS, Patel M, Parkinson EI, Wang Y, Williams NS, et al: An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis. Cancer Res. 72:3038–3047. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ji M, Jin A, Sun J, Cui X, Yang Y, Chen L and Lin Z: Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma. Oncol Lett 13: 2996-3002, 2017.
APA
Ji, M., Jin, A., Sun, J., Cui, X., Yang, Y., Chen, L., & Lin, Z. (2017). Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma. Oncology Letters, 13, 2996-3002. https://doi.org/10.3892/ol.2017.5821
MLA
Ji, M., Jin, A., Sun, J., Cui, X., Yang, Y., Chen, L., Lin, Z."Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma". Oncology Letters 13.5 (2017): 2996-3002.
Chicago
Ji, M., Jin, A., Sun, J., Cui, X., Yang, Y., Chen, L., Lin, Z."Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma". Oncology Letters 13, no. 5 (2017): 2996-3002. https://doi.org/10.3892/ol.2017.5821
Copy and paste a formatted citation
x
Spandidos Publications style
Ji M, Jin A, Sun J, Cui X, Yang Y, Chen L and Lin Z: Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma. Oncol Lett 13: 2996-3002, 2017.
APA
Ji, M., Jin, A., Sun, J., Cui, X., Yang, Y., Chen, L., & Lin, Z. (2017). Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma. Oncology Letters, 13, 2996-3002. https://doi.org/10.3892/ol.2017.5821
MLA
Ji, M., Jin, A., Sun, J., Cui, X., Yang, Y., Chen, L., Lin, Z."Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma". Oncology Letters 13.5 (2017): 2996-3002.
Chicago
Ji, M., Jin, A., Sun, J., Cui, X., Yang, Y., Chen, L., Lin, Z."Clinicopathological implications of NQO1 overexpression in the prognosis of pancreatic adenocarcinoma". Oncology Letters 13, no. 5 (2017): 2996-3002. https://doi.org/10.3892/ol.2017.5821
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team