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Review Open Access

Role of stem cell-derived exosomes in cancer (Review)

  • Authors:
    • Junyi Wu
    • Zhen Qu
    • Zi‑Wei Fei
    • Jun‑Hua Wu
    • Chun‑Ping Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital, Medical School, Nanjing University, Nanjing, Jiangsu 210008, P.R. China, Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, Jiangsu 210093, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2855-2866
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    Published online on: March 7, 2017
       https://doi.org/10.3892/ol.2017.5824
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Abstract

Exosomes are small, extracellular membrane-enclosed vesicles that contain a variety of molecules, including proteins, DNA, mRNA and non-coding RNA; these vesicles have been defined as new tools for intercellular communication between cells. Numerous types of cells, including stem cells, secrete exosomes into the extracellular environment, and are significant communicators in the tumor microenvironment. Stem cells are a unique cell population defined by their ability to indefinitely self-renew, differentiate into a variety of cell lines, and form clonal cell populations. Stem cells also secrete large amounts of exosomes, which have demonstrated great potential in a variety of diseases. Increasing evidence has revealed that the mechanism of interaction between stem cells and human tumor cells involves the exchange of biological material through exosomes. In this review, the latest developments in the role of stem cell‑derived exosomes in cancer are highlighted.
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1 

Lopatina T, Gai C, Deregibus MC, Kholia S and Camussi G: Cross talk between cancer and mesenchymal stem cells through extracellular vesicles carrying nucleic acids. Front Oncol. 6:1252016. View Article : Google Scholar : PubMed/NCBI

2 

Trams EG, Lauter CJ, Salem N Jr and Heine U: Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim Biophys Acta. 645:63–70. 1981. View Article : Google Scholar : PubMed/NCBI

3 

Vlassov AV, Magdaleno S, Setterquist R and Conrad R: Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta. 1820:940–948. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brügger B and Simons M: Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science. 319:1244–1247. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Brinton LT, Sloane HS, Kester M and Kelly KA: Formation and role of exosomes in cancer. Cell Mol Life Sci. 72:659–671. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Kowal J, Tkach M and Théry C: Biogenesis and secretion of exosomes. Curr Opin Cell Biol. 29:116–125. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Colombo M, Moita C, van Niel G, Kowal J, Vigneron J, Benaroch P, Manel N, Moita LF, Théry C and Raposo G: Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J Cell Sci. 126:5553–5565. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Mathivanan S, Fahner CJ, Reid GE and Simpson RJ: ExoCarta 2012: Database of exosomal proteins, RNA and lipids. Nucleic Acids Res. 40:(Database Issue). D1241–D1244. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Théry C, Regnault A, Garin J, Wolfers J, Zitvogel L, Ricciardi-Castagnoli P, Raposo G and Amigorena S: Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol. 147:599–610. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Bang C and Thum T: Exosomes: New players in cell-cell communication. Int J Biochem Cell Biol. 44:2060–2064. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ and Lötvall JO: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 9:654–659. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Thakur BK, Zhang H, Becker A, Matei I, Huang Y, Costa-Silva B, Zheng Y, Hoshino A, Brazier H, Xiang J, et al: Double-stranded DNA in exosomes: A novel biomarker in cancer detection. Cell Res. 24:766–769. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ismail N, Wang Y, Dakhlallah D, Moldovan L, Agarwal K, Batte K, Shah P, Wisler J, Eubank TD, Tridandapani S, et al: Macrophage microvesicles induce macrophage differentiation and miR-223 transfer. Blood. 121:984–995. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Tolmachova T, Anders R, Stinchcombe J, Bossi G, Griffiths GM, Huxley C and Seabra MC: A general role for Rab27a in secretory cells. Mol Biol Cell. 15:332–344. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Zylbersztejn K and Galli T: Vesicular traffic in cell navigation. FEBS J. 278:4497–4505. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Zhang X, Yuan X, Shi H, Wu L, Qian H and Xu W: Exosomes in cancer: Small particle, big player. J Hematol Oncol. 8:832015. View Article : Google Scholar : PubMed/NCBI

17 

Thompson CA, Purushothaman A, Ramani VC, Vlodavsky I and Sanderson RD: Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J Biol Chem. 288:10093–10099. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Gruenberg J and van der Goot FG: Mechanisms of pathogen entry through the endosomal compartments. Nat Rev Mol Cell Biol. 7:495–504. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Yu X, Harris SL and Levine AJ: The regulation of exosome secretion: A novel function of the p53 protein. Cancer Res. 66:4795–4801. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Vicencio JM, Yellon DM, Sivaraman V, Das D, Boi-Doku C, Arjun S, Zheng Y, Riquelme JA, Kearney J, Sharma V, et al: Plasma exosomes protect the myocardium from ischemia-reperfusion injury. J Am Coll Cardiol. 65:1525–1536. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Meckes DG Jr and Raab-Traub N: Microvesicles and viral infection. J Virol. 85:12844–12854. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Admyre C, Johansson SM, Qazi KR, Filén JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A and Gabrielsson S: Exosomes with immune modulatory features are present in human breast milk. J Immunol. 179:1969–1978. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Robbins PD and Morelli AE: Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 14:195–208. 2014. View Article : Google Scholar : PubMed/NCBI

24 

De Toro J, Herschlik L, Waldner C and Mongini C: Emerging roles of exosomes in normal and pathological conditions: New insights for diagnosis and therapeutic applications. Front Immunol. 6:2032015. View Article : Google Scholar : PubMed/NCBI

25 

Masyuk AI, Masyuk TV and Larusso NF: Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases. J Hepatol. 59:621–625. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Miller IV and Grunewald TG: Tumour-derived exosomes: Tiny envelopes for big stories. Biol Cell. 107:287–305. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Caplan AI: Mesenchymal stem cells. J Orthop Res. 9:641–650. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Bieback K and Klüter H: Mesenchymal stromal cells from umbilical cord blood. Curr Stem Cell Res Ther. 2:310–323. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Lu T, Hu P, Su X, Li C, Ma Y and Guan W: Isolation and characterization of mesenchymal stem cells derived from fetal bovine liver. Cell Tissue Bank. 15:439–450. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Natunen S, Lampinen M, Suila H, Ritamo I, Pitkänen V, Nairn AV, Räbinä J, Laitinen S, Moremen KW, Reutter W and Valmu L: Metabolic glycoengineering of mesenchymal stromal cells with N-propanoylmannosamine. Glycobiology. 23:1004–1012. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Park JS, Suryaprakash S, Lao YH and Leong KW: Engineering mesenchymal stem cells for regenerative medicine and drug delivery. Methods. 84:3–16. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Baglio SR, Pegtel DM and Baldini N: Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol. 3:3592012. View Article : Google Scholar : PubMed/NCBI

33 

Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL and Weinberg RA: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 121:335–348. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Huang WH, Chang MC, Tsai KS, Hung MC, Chen HL and Hung SC: Mesenchymal stem cells promote growth and angiogenesis of tumors in mice. Oncogene. 32:4343–4354. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R and Weinberg RA: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 449:557–563. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Ljujic B, Milovanovic M, Volarevic V, Murray B, Bugarski D, Przyborski S, Arsenijevic N, Lukic ML and Stojkovic M: Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice. Sci Rep. 3:22982013. View Article : Google Scholar : PubMed/NCBI

37 

Akyurekli C, Le Y, Richardson RB, Fergusson D, Tay J and Allan DS: A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles. Stem Cell Rev. 11:150–160. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Ratajczak J, Miekus K, Kucia M, Zhang J, Reca R, Dvorak P and Ratajczak MZ: Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: Evidence for horizontal transfer of mRNA and protein delivery. Leukemia. 20:847–856. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Grange C, Tapparo M, Collino F, Vitillo L, Damasco C, Deregibus MC, Tetta C, Bussolati B and Camussi G: Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res. 71:5346–5356. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Takebe N, Miele L, Harris PJ, Jeong W, Bando H, Kahn M, Yang SX and Ivy SP: Targeting notch, hedgehog, and Wnt pathways in cancer stem cells: Clinical update. Nat Rev Clin Oncol. 12:445–464. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Hannafon BN and Ding WQ: Cancer stem cells and exosome signaling. Stem Cell Investig. 2:112015.PubMed/NCBI

42 

Bourkoula E, Mangoni D, Ius T, Pucer A, Isola M, Musiello D, Marzinotto S, Toffoletto B, Sorrentino M, Palma A, et al: Glioma-associated stem cells: A novel class of tumor-supporting cells able to predict prognosis of human low-grade gliomas. Stem Cells. 32:1239–1253. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Setti M, Osti D, Richichi C, Ortensi B, Del Bene M, Fornasari L, Beznoussenko G, Mironov A, Rappa G, Cuomo A, et al: Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth. Oncotarget. 6:31413–31427. 2015.PubMed/NCBI

44 

Kumar D, Gupta D, Shankar S and Srivastava RK: Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer. Oncotarget. 6:3280–3291. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Kahlert C and Kalluri R: Exosomes in tumor microenvironment influence cancer progression and metastasis. J Mol Med (Berl). 91:431–437. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Vallabhaneni KC, Penfornis P, Dhule S, Guillonneau F, Adams KV, Mo YY, Xu R, Liu Y, Watabe K, Vemuri MC and Pochampally R: Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites. Oncotarget. 6:4953–4967. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Zhu W, Huang L, Li Y, Zhang X, Gu J, Yan Y, Xu X, Wang M, Qian H and Xu W: Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Lett. 315:28–37. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Hernanda PY, Pedroza-Gonzalez A, van der Laan LJ, Bröker ME, Hoogduijn MJ, Ijzermans JN, Bruno MJ, Janssen HL, Peppelenbosch MP and Pan Q: Tumor promotion through the mesenchymal stem cell compartment in human hepatocellular carcinoma. Carcinogenesis. 34:2330–2340. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Yang Y, Bucan V, Baehre H, von der Ohe J, Otte A and Hass R: Acquisition of new tumor cell properties by MSC-derived exosomes. Int J Oncol. 47:244–252. 2015.PubMed/NCBI

50 

Del Fattore A, Luciano R, Saracino R, Battafarano G, Rizzo C, Pascucci L, Alessandri G, Pessina A, Perrotta A, Fierabracci A and Muraca M: Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells. Expert Opin Biol Ther. 15:495–504. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Bruno S, Collino F, Deregibus MC, Grange C, Tetta C and Camussi G: Microvesicles derived from human bone marrow mesenchymal stem cells inhibit tumor growth. Stem Cells Dev. 22:758–771. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Katakowski M, Buller B, Zheng X, Lu Y, Rogers T, Osobamiro O, Shu W, Jiang F and Chopp M: Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth. Cancer Lett. 335:201–204. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Katakowski M, Zheng X, Jiang F, Rogers T, Szalad A and Chopp M: MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma. Cancer Invest. 28:1024–1030. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Roccaro AM, Sacco A, Maiso P, Azab AK, Tai YT, Reagan M, Azab F, Flores LM, Campigotto F, Weller E, et al: BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest. 123:1542–1555. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Wu S, Ju GQ, Du T, Zhu YJ and Liu GH: Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo. PLoS One. 8:e613662013. View Article : Google Scholar : PubMed/NCBI

56 

Biancone L, Bruno S, Deregibus MC, Tetta C and Camussi G: Therapeutic potential of mesenchymal stem cell-derived microvesicles. Nephrol Dial Transplant. 27:3037–3042. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Salomon C, Ryan J, Sobrevia L, Kobayashi M, Ashman K, Mitchell M and Rice GE: Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. PLoS One. 8:e684512013. View Article : Google Scholar : PubMed/NCBI

58 

Lopatina T, Bruno S, Tetta C, Kalinina N, Porta M and Camussi G: Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential. Cell Commun Signal. 12:262014. View Article : Google Scholar : PubMed/NCBI

59 

Lee JK, Park SR, Jung BK, Jeon YK, Lee YS, Kim MK, Kim YG, Jang JY and Kim CW: Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS One. 8:e842562013. View Article : Google Scholar : PubMed/NCBI

60 

Borgström P, Hillan KJ, Sriramarao P and Ferrara N: Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res. 56:4032–4039. 1996.PubMed/NCBI

61 

Chamorro-Jorganes A, Araldi E, Penalva LO, Sandhu D, Fernández-Hernando C and Suárez Y: MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol. 31:2595–2606. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Dejean E, Renalier MH, Foisseau M, Agirre X, Joseph N, de Paiva GR, Al Saati T, Soulier J, Desjobert C, Lamant L, et al: Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas. Leukemia. 25:1882–1890. 2011. View Article : Google Scholar : PubMed/NCBI

63 

Hua Z, Lv Q, Ye W, Wong CK, Cai G, Gu D, Ji Y, Zhao C, Wang J, Yang BB and Zhang Y: MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One. 1:e1162006. View Article : Google Scholar : PubMed/NCBI

64 

Chang AI, Schwertschkow AH, Nolta JA and Wu J: Involvement of mesenchymal stem cells in cancer progression and metastases. Curr Cancer Drug Targets. 15:88–98. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Wang M, Zhao C, Shi H, Zhang B, Zhang L, Zhang X, Wang S, Wu X, Yang T, Huang F, et al: Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: Novel biomarkers and a mechanism for gastric cancer. Br J Cancer. 110:1199–1210. 2014. View Article : Google Scholar : PubMed/NCBI

66 

Lin R, Wang S and Zhao RC: Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model. Mol Cell Biochem. 383:13–20. 2013. View Article : Google Scholar : PubMed/NCBI

67 

Wolfson B, Eades G and Zhou Q: Roles of microRNA-140 in stem cell-associated early stage breast cancer. World J Stem Cells. 6:591–597. 2014. View Article : Google Scholar : PubMed/NCBI

68 

Li Q, Eades G, Yao Y, Zhang Y and Zhou Q: Characterization of a stem-like subpopulation in basal-like ductal carcinoma in situ (DCIS) lesions. J Biol Chem. 289:1303–1312. 2014. View Article : Google Scholar : PubMed/NCBI

69 

Lee HK, Finniss S, Cazacu S, Bucris E, Ziv-Av A, Xiang C, Bobbitt K, Rempel SA, Hasselbach L, Mikkelsen T, et al: Mesenchymal stem cells deliver synthetic microRNA mimics to glioma cells and glioma stem cells and inhibit their cell migration and self-renewal. Oncotarget. 4:346–361. 2013. View Article : Google Scholar : PubMed/NCBI

70 

Ono M, Kosaka N, Tominaga N, Yoshioka Y, Takeshita F, Takahashi RU, Yoshida M, Tsuda H, Tamura K and Ochiya T: Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci Signal. 7:ra632014. View Article : Google Scholar : PubMed/NCBI

71 

Shimbo K, Miyaki S, Ishitobi H, Kato Y, Kubo T, Shimose S and Ochi M: Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. Biochem Biophys Res Commun. 445:381–387. 2014. View Article : Google Scholar : PubMed/NCBI

72 

Hamburg MA and Collins FS: The path to personalized medicine. N Engl J Med. 363:301–304. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Dai S, Wei D, Wu Z, Zhou X, Wei X, Huang H and Li G: Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther. 16:782–790. 2008. View Article : Google Scholar : PubMed/NCBI

74 

Greco SJ and Rameshwar P: Mesenchymal stem cells in drug/gene delivery: Implications for cell therapy. Ther Deliv. 3:997–1004. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Matuskova M, Hlubinova K, Pastorakova A, Hunakova L, Altanerova V, Altaner C and Kucerova L: HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells. Cancer Lett. 290:58–67. 2010. View Article : Google Scholar : PubMed/NCBI

76 

Chen TS and Lim SK: Measurement of precursor miRNA in exosomes from human ESC-derived mesenchymal stem cells. Methods Mol Biol. 1024:69–86. 2013. View Article : Google Scholar : PubMed/NCBI

77 

Lim PK, Bliss SA, Patel SA, Taborga M, Dave MA, Gregory LA, Greco SJ, Bryan M, Patel PS and Rameshwar P: Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. Cancer Res. 71:1550–1560. 2011. View Article : Google Scholar : PubMed/NCBI

78 

Munoz JL, Bliss SA, Greco SJ, Ramkissoon SH, Ligon KL and Rameshwar P: Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity. Mol Ther Nucleic Acids. 2:e1262013. View Article : Google Scholar : PubMed/NCBI

79 

Boelens MC, Wu TJ, Nabet BY, Xu B, Qiu Y, Yoon T, Azzam DJ, Twyman-Saint Victor C, Wiemann BZ, Ishwaran H, et al: Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell. 159:499–513. 2014. View Article : Google Scholar : PubMed/NCBI

80 

Lou G, Song X, Yang F, Wu S, Wang J, Chen Z and Liu Y: Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma. J Hematol Oncol. 8:1222015. View Article : Google Scholar : PubMed/NCBI

81 

Greco KA, Franzen CA, Foreman KE, Flanigan RC, Kuo PC and Gupta GN: PLK-1 silencing in bladder cancer by siRNA delivered with exosomes. Urology. 91:241.e1–e7. 2016. View Article : Google Scholar

82 

Pascucci L, Coccè V, Bonomi A, Ami D, Ceccarelli P, Ciusani E, Viganò L, Locatelli A, Sisto F, Doglia SM, et al: Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery. J Control Release. 192:262–270. 2014. View Article : Google Scholar : PubMed/NCBI

83 

Fuhrmann G, Serio A, Mazo M, Nair R and Stevens MM: Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins. J Control Release. 205:35–44. 2015. View Article : Google Scholar : PubMed/NCBI

84 

Fonsato V, Collino F, Herrera MB, Cavallari C, Deregibus MC, Cisterna B, Bruno S, Romagnoli R, Salizzoni M, Tetta C and Camussi G: Human liver stem cell-derived microvesicles inhibit hepatoma growth in SCID mice by delivering antitumor microRNAs. Stem Cells. 30:1985–1998. 2012. View Article : Google Scholar : PubMed/NCBI

85 

Gjorgieva D, Zaidman N and Bosnakovski D: Mesenchymal stem cells for anti-cancer drug delivery. Recent Pat Anticancer Drug Discov. 8:310–318. 2013. View Article : Google Scholar : PubMed/NCBI

86 

Toh WS, Lai RC, Hui JH and Lim SK: MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment. Semin Cell Dev Biol. Nov 18–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

87 

Sherman LS, Shaker M, Mariotti V and Rameshwar P: Mesenchymal stromal/stem cells in drug therapy: New perspective. Cytotherapy. 19:19–27. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Qu Z, Fei ZW, Wu JH and Jiang CP: Role of stem cell-derived exosomes in cancer (Review). Oncol Lett 13: 2855-2866, 2017.
APA
Wu, J., Qu, Z., Fei, Z., Wu, J., & Jiang, C. (2017). Role of stem cell-derived exosomes in cancer (Review). Oncology Letters, 13, 2855-2866. https://doi.org/10.3892/ol.2017.5824
MLA
Wu, J., Qu, Z., Fei, Z., Wu, J., Jiang, C."Role of stem cell-derived exosomes in cancer (Review)". Oncology Letters 13.5 (2017): 2855-2866.
Chicago
Wu, J., Qu, Z., Fei, Z., Wu, J., Jiang, C."Role of stem cell-derived exosomes in cancer (Review)". Oncology Letters 13, no. 5 (2017): 2855-2866. https://doi.org/10.3892/ol.2017.5824
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Qu Z, Fei ZW, Wu JH and Jiang CP: Role of stem cell-derived exosomes in cancer (Review). Oncol Lett 13: 2855-2866, 2017.
APA
Wu, J., Qu, Z., Fei, Z., Wu, J., & Jiang, C. (2017). Role of stem cell-derived exosomes in cancer (Review). Oncology Letters, 13, 2855-2866. https://doi.org/10.3892/ol.2017.5824
MLA
Wu, J., Qu, Z., Fei, Z., Wu, J., Jiang, C."Role of stem cell-derived exosomes in cancer (Review)". Oncology Letters 13.5 (2017): 2855-2866.
Chicago
Wu, J., Qu, Z., Fei, Z., Wu, J., Jiang, C."Role of stem cell-derived exosomes in cancer (Review)". Oncology Letters 13, no. 5 (2017): 2855-2866. https://doi.org/10.3892/ol.2017.5824
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