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Article

Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells

  • Authors:
    • Kuang Changchun
    • Hu Pengchao
    • Su Ke
    • Wang Ying
    • Wei Lei
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Pathophysiology, Research Center of Food and Drug Evaluation, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
  • Pages: 3253-3260
    |
    Published online on: March 8, 2017
       https://doi.org/10.3892/ol.2017.5825
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Abstract

Interleukin-17 (IL-17) and tumor necrosis factor (TNF)‑α are able to cooperatively alter the expression levels of a number of genes. In the present study, the mRNA expression levels of hypoxia‑inducible factor (HIF)‑1α were analyzed in MDA-MB-231 breast cancer cells following treatment with IL‑17, TNF‑α or the combination of IL‑17 and TNF‑α. The protein expression levels of HIF‑1α and vasodilator‑stimulated phosphoprotein (VASP) were evaluated using western blot analysis. The adhesive ability of the cells was determined using an MTT assay following treatment with HIF‑1α‑small interfering RNA and short hairpin RNA‑VASP that were used to suppress the expression levels of HIF‑1α and VASP protein, respectively. These results demonstrated that IL‑17 augmented TNF‑α‑induced gene expression of HIF‑1α. The combination of IL‑17 and TNF‑α promoted an increase in HIF‑1α expression and a decrease in VASP expression and a reduction in the adhesive ability of cells. These results demonstrated that IL‑17 effectively enhanced the TNF-α-induced increase in HIF‑1α and inhibited VASP expression, thus reducing the adhesion of MDA-MB-231 cells.
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1 

van Horssen R, Ten Hagen TL and Eggermont AM: TNF-alpha in cancer treatment: Molecular insights, antitumor effects, and clinical utility. Oncologist. 11:397–408. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Wilt SG, Milward E, Zhou JM, Nagasato K, Patton H, Rusten R, Griffin DE, O'Connor M and Dubois-Dalcq M: In vitro evidence for a dual role of tumor necrosis factor-alpha in human immunodeficiency virus type 1 encephalopathy. Ann Neurol. 37:381–394. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Han YP, Nien YD and Garner WL: Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase. J Biol Chem. 277:27319–27327. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Jammal MP, DA Silva AA, Filho AM, DE Castro Côbo E, Adad SJ, Murta EF and Nomelini RS: Immunohistochemical staining of tumor necrosis factor-α and interleukin-10 in benign and malignant ovarian neoplasms. Oncol Lett. 9:979–983. 2015.PubMed/NCBI

5 

Zhu N, Lalla R, Eves P, Brown TL, King A, Kemp EH, Haycock JW and MacNeil S: Melanoma cell migration is upregulated by tumour necrosis factor-alpha and suppressed by alpha-melanocyte-stimulating hormone. Br J Cancer. 90:1457–1463. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Chen M and Geng JG: P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis. Arch Immunol Ther Exp (Warsz). 54:75–84. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, Bamba T and Fujiyama Y: Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 52:65–70. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM and Fugger L: Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol. 172:146–155. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Chabaud M, Garnero P, Dayer JM, Guerne PA, Fossiez F and Miossec P: Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis. Cytokine. 12:1092–1099. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Wilke CM, Kryczek I, Wei S, Zhao E, Wu K, Wang G and Zou W: Th17 cells in cancer: Help or hindrance? Carcinogenesis. 32:643–649. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Wilke CM, Bishop K, Fox D and Zou W: Deciphering the role of Th17 cells in human disease. Trends Immunol. 32:603–611. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Hu J, Ye H, Zhang D, Liu W, Li M, Mao Y and Lu Y: U87MG glioma cells overexpressing IL-17 acclerate early-stage growth and cause a higher level of CD31 mRNA expression in tumor tissues. Oncol Lett. 6:993–999. 2013.PubMed/NCBI

13 

Hot A, Zrioual S, Lenief V and Miossec P: IL-17 and tumour necrosis factor alpha combination induces a HIF-1α-dependent invasive phenotype in synoviocytes. Ann Rheum Dis. 71:1393–1401. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Karlsen JR, Borregaard N and Cowland JB: Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta. J Biol Chem. 285:14088–14100. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Andoh A, Yasui H, Inatomi O, Zhang Z, Deguchi Y, Hata K, Araki Y, Tsujikawa T, Kitoh K, Kim-Mitsuyama S, et al: Interleukin-17 augments tumor necrosis factor-alpha-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts. J Gastroenterol. 40:802–810. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Numasaki M, Lotze MT and Sasaki H: Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts. Immunol Lett. 93:39–43. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Hamilton T, Li X, Novotny M, Pavicic PG Jr, Datta S, Zhao C, Hartupee J and Sun D: Cell type- and stimulus-specific mechanisms for post-transcriptional control of neutrophil chemokine gene expression. J Leukoc Biol. 91:377–383. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Koenders MI, Marijnissen RJ, Devesa I, Lubberts E, Joosten LA, Roth J, van Lent PL, van de Loo FA and van den Berg WB: Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: Rationale for combination treatment during arthritis. Arthritis Rheum. 63:2329–2339. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Chiricozzi A, Guttman-Yassky E, Suárez-Fariñas M, Nograles KE, Tian S, Cardinale I, Chimenti S and Krueger JG: Integrative responses to IL-17 and TNF-alpha in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. The Journal of investigative dermatology. 131:677–687. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Barzik M, Kotova TI, Higgs HN, Hazelwood L, Hanein D, Gertler FB and Schafer DA: Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J Biol Chem. 280:28653–28662. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Schirenbeck A, Arasada R, Bretschneider T, Stradal TE, Schleicher M and Faix J: The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation. Proc Natl Acad Sci USA. 103:7694–7699. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Krause M, Dent EW, Bear JE, Loureiro JJ and Gertler FB: Ena/VASP proteins: Regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol. 19:541–564. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Dertsiz L, Ozbilim G, Kayisli Y, Gokhan GA, Demircan A and Kayisli UA: Differential expression of VASP in normal lung tissue and lung adenocarcinomas. Thorax. 60:576–581. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Su K, Tian Y, Wang J, Shi W, Luo D, Liu J, Tong Z, Wu J, Zhang J and Wei L: HIF-1alpha acts downstream of TNF-α to inhibit vasodilator-stimulated phosphoprotein expression and modulates the adhesion and proliferation of breast cancer cells. DNA Cell Biol. 31:1078–1087. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Tang M, Tian Y, Li D, Lv J, Li Q, Kuang C, Hu P, Wang Y, Wang J, Su K and Wei L: TNF-α mediated increase of HIF-1α inhibits VASP expression, which reduces alveolar-capillary barrier function during acute lung injury (ALI). PloS One. 9:e1029672014. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Wang J, Zhang J, Wu J, Luo D, Su K, Shi W, Liu J, Tian Y and Wei L: MicroRNA-610 inhibits the migration and invasion of gastric cancer cells by suppressing the expression of vasodilator-stimulated phosphoprotein. Eur J Cancer. 48:1904–1913. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Kato R, Ishikawa T, Kamiya S, Oguma F, Ueki M, Goto S, Nakamura H, Katayama T and Fukai F: A new type of antimetastatic peptide derived from fibronectin. Clin Cancer Res. 8:2455–2462. 2002.PubMed/NCBI

29 

Galler AB, Arguinzonis Garcia MI, Baumgartner W, Kuhn M, Smolenski A, Simm A and Reinhard M: VASP-dependent regulation of actin cytoskeleton rigidity, cell adhesion, and detachment. Histochem Cell Biol. 125:457–474. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Straus DS: TNFα and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. Mol Cancer. 12:782013. View Article : Google Scholar : PubMed/NCBI

31 

Stroka KM and Konstantopoulos K: Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration. Am J Physiol Cell Physiol. 306:C98–C109. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Mareel M and Leroy A: Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev. 83:337–376. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Bhatt T, Rizvi A, Batta SP, Kataria S and Jamora C: Signaling and mechanical roles of E-cadherin. Cell Commun Adhes. 20:189–199. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Le Clainche C and Carlier MF: Regulation of actin assembly associated with protrusion and adhesion in cell migration. Physiol Rev. 88:489–513. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Pula G and Krause M: Role of Ena/VASP proteins in homeostasis and disease. Handb Exp Pharmacol. 39–65. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Lebrand C, Dent EW, Strasser GA, Lanier LM, Krause M, Svitkina TM, Borisy GG and Gertler FB: Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron. 42:37–49. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Doppler H and Storz P: Regulation of VASP by phosphorylation: consequences for cell migration. Cell Adh Migr. 7:482–486. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Bear JE and Gertler FB: Ena/VASP: Towards resolving a pointed controversy at the barbed end. J Cell Sci. 122:1947–1953. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Trichet L, Sykes C and Plastino J: Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP. J Cell Biol. 181:19–25. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Changchun K, Pengchao H, Ke S, Ying W and Lei W: Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells. Oncol Lett 13: 3253-3260, 2017.
APA
Changchun, K., Pengchao, H., Ke, S., Ying, W., & Lei, W. (2017). Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells. Oncology Letters, 13, 3253-3260. https://doi.org/10.3892/ol.2017.5825
MLA
Changchun, K., Pengchao, H., Ke, S., Ying, W., Lei, W."Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells". Oncology Letters 13.5 (2017): 3253-3260.
Chicago
Changchun, K., Pengchao, H., Ke, S., Ying, W., Lei, W."Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells". Oncology Letters 13, no. 5 (2017): 3253-3260. https://doi.org/10.3892/ol.2017.5825
Copy and paste a formatted citation
x
Spandidos Publications style
Changchun K, Pengchao H, Ke S, Ying W and Lei W: Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells. Oncol Lett 13: 3253-3260, 2017.
APA
Changchun, K., Pengchao, H., Ke, S., Ying, W., & Lei, W. (2017). Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells. Oncology Letters, 13, 3253-3260. https://doi.org/10.3892/ol.2017.5825
MLA
Changchun, K., Pengchao, H., Ke, S., Ying, W., Lei, W."Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells". Oncology Letters 13.5 (2017): 3253-3260.
Chicago
Changchun, K., Pengchao, H., Ke, S., Ying, W., Lei, W."Interleukin-17 augments tumor necrosis factor α-mediated increase of hypoxia-inducible factor-1α and inhibits vasodilator-stimulated phosphoprotein expression to reduce the adhesion of breast cancer cells". Oncology Letters 13, no. 5 (2017): 3253-3260. https://doi.org/10.3892/ol.2017.5825
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