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Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer

  • Authors:
    • Xiumei Zhao
    • Jing Zhao
    • Renjie Hu
    • Qiang Yao
    • Guixian Zhang
    • Hongsheng Shen
    • Ernesto Yagüe
    • Yunhui Hu
  • View Affiliations / Copyright

    Affiliations: Centre for Research and Development of Anti Tumor Drugs, Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, P.R. China, The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Tianjin People's Hospital, Tianjin 300121, P.R. China, Cancer Research Center, Division of Cancer, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3071-3079
    |
    Published online on: March 8, 2017
       https://doi.org/10.3892/ol.2017.5832
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Abstract

Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia ternata), Xia ku cao (Prunella vulgaris), Shan ci gu (Cremastra appendiculata) and Hai zao (Sargassum pallidum), and has traditionally been used for softening hard lumps and resolving hard tissue masses. However, the active compounds and mechanisms of action of RJSJ remain unknown. The present study demonstrated the antitumor activity of RJSJ against Ehrlich ascites carcinoma in Swiss albino mice and breast cancer xenografts in nude mice. Notably, RJSJ does not induce body weight loss, immune function toxicity or myelosuppression in mice, indicating that it is safe and well tolerated. In addition, RJSJ shows potent cytotoxicity against breast cancer cells in vitro by the suppression of the anti‑apoptotic proteins B‑cell lymphoma 2 and survivin, leading to the activation of caspase-3/7 and caspase-9, and the apoptotic cascade. These findings provide a clear rationale to explore the therapeutic strategy of using RJSJ alone or in combination with chemotherapeutic agents for breast cancer patients and the characterization of its active principles.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Zhao J, Hu R, Yao Q, Zhang G, Shen H, Yagüe E and Hu Y: Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer. Oncol Lett 13: 3071-3079, 2017.
APA
Zhao, X., Zhao, J., Hu, R., Yao, Q., Zhang, G., Shen, H. ... Hu, Y. (2017). Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer. Oncology Letters, 13, 3071-3079. https://doi.org/10.3892/ol.2017.5832
MLA
Zhao, X., Zhao, J., Hu, R., Yao, Q., Zhang, G., Shen, H., Yagüe, E., Hu, Y."Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer". Oncology Letters 13.5 (2017): 3071-3079.
Chicago
Zhao, X., Zhao, J., Hu, R., Yao, Q., Zhang, G., Shen, H., Yagüe, E., Hu, Y."Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer". Oncology Letters 13, no. 5 (2017): 3071-3079. https://doi.org/10.3892/ol.2017.5832
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Zhao J, Hu R, Yao Q, Zhang G, Shen H, Yagüe E and Hu Y: Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer. Oncol Lett 13: 3071-3079, 2017.
APA
Zhao, X., Zhao, J., Hu, R., Yao, Q., Zhang, G., Shen, H. ... Hu, Y. (2017). Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer. Oncology Letters, 13, 3071-3079. https://doi.org/10.3892/ol.2017.5832
MLA
Zhao, X., Zhao, J., Hu, R., Yao, Q., Zhang, G., Shen, H., Yagüe, E., Hu, Y."Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer". Oncology Letters 13.5 (2017): 3071-3079.
Chicago
Zhao, X., Zhao, J., Hu, R., Yao, Q., Zhang, G., Shen, H., Yagüe, E., Hu, Y."Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer". Oncology Letters 13, no. 5 (2017): 3071-3079. https://doi.org/10.3892/ol.2017.5832
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