Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China

  • Authors:
    • Kaizhou Jin
    • Guopei Luo
    • Jin Xu
    • Bo Zhang
    • Chen Liu
    • Shunrong Ji
    • Liang Liu
    • Jiang Long
    • Quanxing Ni
    • Xianjun Yu
  • View Affiliations / Copyright

    Affiliations: Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China
  • Pages: 3163-3168
    |
    Published online on: March 9, 2017
       https://doi.org/10.3892/ol.2017.5834
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the clinical, pathological and prognostic characteristics of Chinese patients with resected pancreatic neuroendocrine neoplasms (p‑NENs). Data from patients who were surgically treated and pathologically diagnosed with p‑NENs at the Department of Pancreatic Oncology of the Fudan University Shanghai Cancer Center (Shanghai, China), between January 2003 and July 2015, were evaluated using univariate and multivariate analyses. A total of 162 patients with p‑NENs met the criteria of the present study and were included in the analysis. Patients with poorly differentiated pancreatic neuroendocrine carcinoma (p‑NEC) exhibited a significantly increased rate of lymph node metastasis, as compared with patients with grade (G)1/G2 pancreatic neuroendocrine tumors (p‑NETs) (62.5 vs. 20.5%, P=0.003). Univariate analysis identified that the following factors led to decreased overall survival (OS): Lymph node metastasis (P=0.001, vs. the absence of lymph node metastasis); distant metastasis (P=0.043, vs. the absence of distant metastasis); resection margin R1/R2 (P=0.030, vs. R0 resection); NEC G3 (P<0.001, vs. NET G1). Following the multivariate analysis, NEC G3 remained a statistically significant risk factor (HR=12.593; 95% CI, 3.476‑45.622; P<0.001, vs. NET G1/G2). Furthermore, according to the proliferation marker protein Ki‑67 staining index, assigning a grade using the proliferative index (G1, ≤5%; G2, >5‑20%; G3, >20%) was more efficient for prognostic stratification compared with the European Neuroendocrine Tumor Society (Berlin, Germany)/World Health Organization (Geneva, Switzerland) 2010 grading classification. The present study indicated that p‑NEC was an important predictor of decreased OS in Chinese patients. Furthermore, a Ki‑67 staining index of 5% represented a more efficient value for the distinction between G1 and G2.
View Figures

Figure 1

Figure 2

View References

1 

Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A and Evans DB: One hundred years after ‘carcinoid’: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 26:3063–3072. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Tsai HJ, Wu CC, Tsai CR, Lin SF, Chen LT and Chang JS: The epidemiology of neuroendocrine tumors in Taiwan: A nation-wide cancer registry-based study. PLoS One. 8:e624872013. View Article : Google Scholar : PubMed/NCBI

3 

Capella C, Heitz PU, Höfler H, Solcia E and Klöppel G: Revised classification of neuroendocrine tumours of the lung, pancreas and gut. Virchows Arch. 425:547–560. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Solcia E, Klöppel G and Sobin LH: Histological Typing of Endocrine TumorsWHO International Histological Classification of Tumors. Springer; Berlin, Germany: 2000

5 

Rindi GAR and Bosman FT: ea: Nomenclature and classification of neuroendocrine neoplasms of the digestive systemBosman T, Carneiro F, Hruban R, et al: In: Bosman T, Carneiro F, Hruban R, et al (eds). WHO Classification of Tumours of the Digestive System. 4th. Lyon, France: International Agency for Research on Cancer (IARC); 3. pp. 4172010

6 

Rindi G, Klöppel G, Alhman H, Caplin M, Couvelard A, de Herder WW, Erikssson B, Falchetti A, Falconi M, Komminoth P, et al: TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system. Virchows Arch. 449:395–401. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Edge SBBDR and Compton CC: ea. AJCC Cancer Staging Manual. New York, NY: Springer; 2010

8 

Panzuto F, Boninsegna L, Fazio N, Campana D, Brizzi Pia M, Capurso G, Scarpa A, De Braud F, Dogliotti L, Tomassetti P, et al: Metastatic and locally advanced pancreatic endocrine carcinomas: Analysis of factors associated with disease progression. J Clin Oncol. 29:2372–2377. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kulke MH, Bendell J, Kvols L, Picus J, Pommier R and Yao J: Evolving diagnostic and treatment strategies for pancreatic neuroendocrine tumors. J Hematol Oncol. 4:292011. View Article : Google Scholar : PubMed/NCBI

10 

Dixon E and Pasieka JL: Functioning and nonfunctioning neuroendocrine tumors of the pancreas. Curr Opin Oncol. 19:30–35. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Cheema A, Weber J and Strosberg JR: Incidental detection of pancreatic neuroendocrine tumors: An analysis of incidence and outcomes. Ann Surg Oncol. 19:2932–2936. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Haugvik SP, Janson ET, österlund P, Langer SW, Falk RS, Labori KJ, Vestermark LW, Grønbæk H, Gladhaug IP and Sorbye H: Surgical treatment as a principle for patients with high-grade pancreatic neuroendocrine carcinoma: A nordic multicenter comparative study. Ann Surg Oncol. 23:1721–1728. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Kim MJ, Choi DW, Choi SH, Heo JS, Park HJ, Choi KK, Jang KT and Sung JY: Surgical strategies for non-functioning pancreatic neuroendocrine tumours. Br J Surg. 99:1562–1568. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Hill JS, McPhee JT, McDade TP, Zhou Z, Sullivan ME, Whalen GF and Tseng JF: Pancreatic neuroendocrine tumors: The impact of surgical resection on survival. Cancer. 115:741–751. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Franko J, Feng W, Yip L, Genovese E and Moser AJ: Non-functional neuroendocrine carcinoma of the pancreas: Incidence, tumor biology, and outcomes in 2,158 patients. J Gastrointest Surg. 14:541–548. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Cusati D, Zhang L, Harmsen WS, Hu A, Farnell MB, Nagorney DM, Donohue JH, Que FG, Reid-Lombardo KM and Kendrick ML: Metastatic nonfunctioning pancreatic neuroendocrine carcinoma to liver: Surgical treatment and outcomes. J Am Coll Surg. 215:117–125. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Ekeblad S, Skogseid B, Dunder K, Oberg K and Eriksson B: Prognostic factors and survival in 324 patients with pancreatic endocrine tumor treated at a single institution. Clin Cancer Res. 14:7798–7803. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Ballian N, Loeffler AG, Rajamanickam V, Norstedt PA, Weber SM and Cho CS: A simplified prognostic system for resected pancreatic neuroendocrine neoplasms. HPB (Oxford). 11:422–428. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Fischer L, Bergmann F, Schimmack S, Hinz U, Prieß S, Müller-Stich BP, Werner J, Hackert T and Büchler MW: Outcome of surgery for pancreatic neuroendocrine neoplasms. Br J Surg. 101:1405–1412. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Bettini R, Boninsegna L, Mantovani W, Capelli P, Bassi C, Pederzoli P, Fave GF Delle, Panzuto F, Scarpa A and Falconi M: Prognostic factors at diagnosis and value of WHO classification in a mono-institutional series of 180 non-functioning pancreatic endocrine tumours. Ann Oncol. 19:903–908. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Boninsegna L, Panzuto F, Partelli S, Capelli P, Fave G Delle, Bettini R, Pederzoli P, Scarpa A and Falconi M: Malignant pancreatic neuroendocrine tumour: Lymph node ratio and Ki67 are predictors of recurrence after curative resections. Eur J Cancer. 48:1608–1615. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Khan MS, Luong TV, Watkins J, Toumpanakis C, Caplin ME and Meyer T: A comparison of Ki-67 and mitotic count as prognostic markers for metastatic pancreatic and midgut neuroendocrine neoplasms. Br J Cancer. 108:1838–1845. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Rindi G, Falconi M, Klersy C, Albarello L, Boninsegna L, Buchler MW, Capella C, Caplin M, Couvelard A, Doglioni C, et al: TNM staging of neoplasms of the endocrine pancreas: Results from a large international cohort study. J Natl Cancer Inst. 104:764–777. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Vélayoudom-Céphise FL, Duvillard P, Foucan L, Hadoux J, Chougnet CN, Leboulleux S, Malka D, Guigay J, Goere D, Debaere T, et al: Are G3 ENETS neuroendocrine neoplasms heterogeneous. Endocr Relat Cancer. 20:649–657. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Hashim YM, Trinkaus KM, Linehan DC, Strasberg SS, Fields RC, Cao D and Hawkins WG: Regional lymphadenectomy is indicated in the surgical treatment of pancreatic neuroendocrine tumors (PNETs). Ann Surg. 259:197–203. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Strosberg JR, Cheema A, Weber J, Han G, Coppola D and Kvols LK: Prognostic validity of a novel american joint committee on cancer staging classification for pancreatic neuroendocrine tumors. J Clin Oncol. 29:3044–3049. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Wong J, Fulp WJ, Strosberg JR, Kvols LK, Centeno BA and Hodul PJ: Predictors of lymph node metastases and impact on survival in resected pancreatic neuroendocrine tumors: A single-center experience. Am J Surg. 208:775–780. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, Sedlackova E, Toumpanakis C, Anlauf M, Cwikla JB, et al: ENETS consensus guidelines for high-grade gastroenteropancreatic neuroendocrine tumors and neuroendocrine carcinomas. Neuroendocrinology. 103:186–194. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jin K, Luo G, Xu J, Zhang B, Liu C, Ji S, Liu L, Long J, Ni Q, Yu X, Yu X, et al: Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China. Oncol Lett 13: 3163-3168, 2017.
APA
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S. ... Yu, X. (2017). Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China. Oncology Letters, 13, 3163-3168. https://doi.org/10.3892/ol.2017.5834
MLA
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S., Liu, L., Long, J., Ni, Q., Yu, X."Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China". Oncology Letters 13.5 (2017): 3163-3168.
Chicago
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S., Liu, L., Long, J., Ni, Q., Yu, X."Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China". Oncology Letters 13, no. 5 (2017): 3163-3168. https://doi.org/10.3892/ol.2017.5834
Copy and paste a formatted citation
x
Spandidos Publications style
Jin K, Luo G, Xu J, Zhang B, Liu C, Ji S, Liu L, Long J, Ni Q, Yu X, Yu X, et al: Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China. Oncol Lett 13: 3163-3168, 2017.
APA
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S. ... Yu, X. (2017). Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China. Oncology Letters, 13, 3163-3168. https://doi.org/10.3892/ol.2017.5834
MLA
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S., Liu, L., Long, J., Ni, Q., Yu, X."Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China". Oncology Letters 13.5 (2017): 3163-3168.
Chicago
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S., Liu, L., Long, J., Ni, Q., Yu, X."Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China". Oncology Letters 13, no. 5 (2017): 3163-3168. https://doi.org/10.3892/ol.2017.5834
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team