Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China

  • Authors:
    • Kaizhou Jin
    • Guopei Luo
    • Jin Xu
    • Bo Zhang
    • Chen Liu
    • Shunrong Ji
    • Liang Liu
    • Jiang Long
    • Quanxing Ni
    • Xianjun Yu
  • View Affiliations

  • Published online on: March 9, 2017     https://doi.org/10.3892/ol.2017.5834
  • Pages: 3163-3168
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Abstract

The aim of the present study was to investigate the clinical, pathological and prognostic characteristics of Chinese patients with resected pancreatic neuroendocrine neoplasms (p‑NENs). Data from patients who were surgically treated and pathologically diagnosed with p‑NENs at the Department of Pancreatic Oncology of the Fudan University Shanghai Cancer Center (Shanghai, China), between January 2003 and July 2015, were evaluated using univariate and multivariate analyses. A total of 162 patients with p‑NENs met the criteria of the present study and were included in the analysis. Patients with poorly differentiated pancreatic neuroendocrine carcinoma (p‑NEC) exhibited a significantly increased rate of lymph node metastasis, as compared with patients with grade (G)1/G2 pancreatic neuroendocrine tumors (p‑NETs) (62.5 vs. 20.5%, P=0.003). Univariate analysis identified that the following factors led to decreased overall survival (OS): Lymph node metastasis (P=0.001, vs. the absence of lymph node metastasis); distant metastasis (P=0.043, vs. the absence of distant metastasis); resection margin R1/R2 (P=0.030, vs. R0 resection); NEC G3 (P<0.001, vs. NET G1). Following the multivariate analysis, NEC G3 remained a statistically significant risk factor (HR=12.593; 95% CI, 3.476‑45.622; P<0.001, vs. NET G1/G2). Furthermore, according to the proliferation marker protein Ki‑67 staining index, assigning a grade using the proliferative index (G1, ≤5%; G2, >5‑20%; G3, >20%) was more efficient for prognostic stratification compared with the European Neuroendocrine Tumor Society (Berlin, Germany)/World Health Organization (Geneva, Switzerland) 2010 grading classification. The present study indicated that p‑NEC was an important predictor of decreased OS in Chinese patients. Furthermore, a Ki‑67 staining index of 5% represented a more efficient value for the distinction between G1 and G2.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jin K, Luo G, Xu J, Zhang B, Liu C, Ji S, Liu L, Long J, Ni Q, Yu X, Yu X, et al: Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China. Oncol Lett 13: 3163-3168, 2017
APA
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S. ... Yu, X. (2017). Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China. Oncology Letters, 13, 3163-3168. https://doi.org/10.3892/ol.2017.5834
MLA
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S., Liu, L., Long, J., Ni, Q., Yu, X."Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China". Oncology Letters 13.5 (2017): 3163-3168.
Chicago
Jin, K., Luo, G., Xu, J., Zhang, B., Liu, C., Ji, S., Liu, L., Long, J., Ni, Q., Yu, X."Clinical outcomes and prognostic factors of resected pancreatic neuroendocrine neoplasms: A single-center experience in China". Oncology Letters 13, no. 5 (2017): 3163-3168. https://doi.org/10.3892/ol.2017.5834