An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome

  • Authors:
    • Leandro Germán Gutiérrez
    • María Fernanda Noriega
    • Alejandro Laudicina
    • Mariana Quatrin
    • Raquel María Bengió
    • Irene Larripa
  • View Affiliations

  • Published online on: March 13, 2017     https://doi.org/10.3892/ol.2017.5845
  • Pages: 3159-3162
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Abstract

Chronic myeloid leukemia (CML) is characterized by the translocation t(9;22)(q34;q11) [Philadelphia (Ph) chromosome). Although not frequently occurring, additional chromosome abnormalities (ACAs) can be detected at diagnosis and a number have been associated with an adverse cytogenetic and molecular outcome. The present study reports a case of CML presenting with the translocation t(1;11)(q21;q23) and a cryptic Ph chromosome. The presence of ACAs could generate greater genetic instability, promoting the emergence of further alterations. The present findings suggest that t(1;11)(q21;q23) can prevent a good response to tyrosine kinase inhibitor (TKI) therapy developing a primary resistance. In the present patient, at a recent follow‑up, the T315I mutation was detected. This mutation confers full resistance to all available TKI, except ponatinib, which was not a therapeutic option due to comorbidities.
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May 2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Gutiérrez, L.G., Noriega, M.F., Laudicina, A., Quatrin, M., Bengió, R.M., & Larripa, I. (2017). An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome. Oncology Letters, 13, 3159-3162. https://doi.org/10.3892/ol.2017.5845
MLA
Gutiérrez, L. G., Noriega, M. F., Laudicina, A., Quatrin, M., Bengió, R. M., Larripa, I."An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome". Oncology Letters 13.5 (2017): 3159-3162.
Chicago
Gutiérrez, L. G., Noriega, M. F., Laudicina, A., Quatrin, M., Bengió, R. M., Larripa, I."An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome". Oncology Letters 13, no. 5 (2017): 3159-3162. https://doi.org/10.3892/ol.2017.5845