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Article

An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome

  • Authors:
    • Leandro Germán Gutiérrez
    • María Fernanda Noriega
    • Alejandro Laudicina
    • Mariana Quatrin
    • Raquel María Bengió
    • Irene Larripa
  • View Affiliations / Copyright

    Affiliations: Laboratory of Hematological Genetics, Institute of Experimental Medicine, National Council of Scientific and Technical Research‑National Academy of Medicine, C1425AUM Buenos Aires, Argentina, Genetics Division, Hematology Research Institute ʻMariano R. Castexʼ, National Academy of Medicine, C1425AUM Buenos Aires, Argentina, Lexel SRL, Division In Vitro, C1135ABO Buenos Aires, Argentina, Laboratory of Genetics, ‘Sor María Ludovica’ Hospital, La Plata, B1904CSI Buenos Aires, Argentina , Clinical‑Hematological Division, Hematology Research Institute ʻMariano R. Castexʼ, National Academy of Medicine, C1425AUM Buenos Aires, Argentina
  • Pages: 3159-3162
    |
    Published online on: March 13, 2017
       https://doi.org/10.3892/ol.2017.5845
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Abstract

Chronic myeloid leukemia (CML) is characterized by the translocation t(9;22)(q34;q11) [Philadelphia (Ph) chromosome). Although not frequently occurring, additional chromosome abnormalities (ACAs) can be detected at diagnosis and a number have been associated with an adverse cytogenetic and molecular outcome. The present study reports a case of CML presenting with the translocation t(1;11)(q21;q23) and a cryptic Ph chromosome. The presence of ACAs could generate greater genetic instability, promoting the emergence of further alterations. The present findings suggest that t(1;11)(q21;q23) can prevent a good response to tyrosine kinase inhibitor (TKI) therapy developing a primary resistance. In the present patient, at a recent follow‑up, the T315I mutation was detected. This mutation confers full resistance to all available TKI, except ponatinib, which was not a therapeutic option due to comorbidities.
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Copy and paste a formatted citation
Spandidos Publications style
Gutiérrez LG, Noriega MF, Laudicina A, Quatrin M, Bengió RM and Larripa I: An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome. Oncol Lett 13: 3159-3162, 2017.
APA
Gutiérrez, L.G., Noriega, M.F., Laudicina, A., Quatrin, M., Bengió, R.M., & Larripa, I. (2017). An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome. Oncology Letters, 13, 3159-3162. https://doi.org/10.3892/ol.2017.5845
MLA
Gutiérrez, L. G., Noriega, M. F., Laudicina, A., Quatrin, M., Bengió, R. M., Larripa, I."An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome". Oncology Letters 13.5 (2017): 3159-3162.
Chicago
Gutiérrez, L. G., Noriega, M. F., Laudicina, A., Quatrin, M., Bengió, R. M., Larripa, I."An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome". Oncology Letters 13, no. 5 (2017): 3159-3162. https://doi.org/10.3892/ol.2017.5845
Copy and paste a formatted citation
x
Spandidos Publications style
Gutiérrez LG, Noriega MF, Laudicina A, Quatrin M, Bengió RM and Larripa I: An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome. Oncol Lett 13: 3159-3162, 2017.
APA
Gutiérrez, L.G., Noriega, M.F., Laudicina, A., Quatrin, M., Bengió, R.M., & Larripa, I. (2017). An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome. Oncology Letters, 13, 3159-3162. https://doi.org/10.3892/ol.2017.5845
MLA
Gutiérrez, L. G., Noriega, M. F., Laudicina, A., Quatrin, M., Bengió, R. M., Larripa, I."An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome". Oncology Letters 13.5 (2017): 3159-3162.
Chicago
Gutiérrez, L. G., Noriega, M. F., Laudicina, A., Quatrin, M., Bengió, R. M., Larripa, I."An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome". Oncology Letters 13, no. 5 (2017): 3159-3162. https://doi.org/10.3892/ol.2017.5845
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