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Article Open Access

MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1

  • Authors:
    • Ping Zhang
    • Feng Kong
    • Xinchao Deng
    • Yunhai Yu
    • Congzhe Hou
    • Tingting Liang
    • Lin Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Central Laboratory, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2949-2956
    |
    Published online on: March 13, 2017
       https://doi.org/10.3892/ol.2017.5852
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Abstract

Although microRNAs (miRNAs or miRs) are able to function as oncogenes or tumor suppressors, the role of miR-326 in regulating human cervical cancer cells remains unclear. In the present study, the expression of miR‑326 was identified to be downregulated in cervical cancer cell lines and primary tumor samples, and the overexpression of miR‑326 decreased cell proliferation, migration and invasion in cervical cell lines. Bioinformatics prediction and experimental validation results revealed that the function of miR‑326 was achieved by targeting and repressing ETS domain-containing protein Elk‑1 (ELK1) expression. ELK1 was targeted directly by miR‑326, which was downregulated in human cervical cancer tissues compared with that in adjacent normal tissues. The results of the present study suggest that miR‑326, a potential tumor suppressor, may be used in the treatment of cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Kong F, Deng X, Yu Y, Hou C, Liang T and Zhu L: MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1. Oncol Lett 13: 2949-2956, 2017.
APA
Zhang, P., Kong, F., Deng, X., Yu, Y., Hou, C., Liang, T., & Zhu, L. (2017). MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1. Oncology Letters, 13, 2949-2956. https://doi.org/10.3892/ol.2017.5852
MLA
Zhang, P., Kong, F., Deng, X., Yu, Y., Hou, C., Liang, T., Zhu, L."MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1". Oncology Letters 13.5 (2017): 2949-2956.
Chicago
Zhang, P., Kong, F., Deng, X., Yu, Y., Hou, C., Liang, T., Zhu, L."MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1". Oncology Letters 13, no. 5 (2017): 2949-2956. https://doi.org/10.3892/ol.2017.5852
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, Kong F, Deng X, Yu Y, Hou C, Liang T and Zhu L: MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1. Oncol Lett 13: 2949-2956, 2017.
APA
Zhang, P., Kong, F., Deng, X., Yu, Y., Hou, C., Liang, T., & Zhu, L. (2017). MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1. Oncology Letters, 13, 2949-2956. https://doi.org/10.3892/ol.2017.5852
MLA
Zhang, P., Kong, F., Deng, X., Yu, Y., Hou, C., Liang, T., Zhu, L."MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1". Oncology Letters 13.5 (2017): 2949-2956.
Chicago
Zhang, P., Kong, F., Deng, X., Yu, Y., Hou, C., Liang, T., Zhu, L."MicroRNA-326 suppresses the proliferation, migration and invasion of cervical cancer cells by targeting ELK1". Oncology Letters 13, no. 5 (2017): 2949-2956. https://doi.org/10.3892/ol.2017.5852
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